Tead1 TEA domain family member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tead1provided by MGI
Official Full Name: TEA domain family member 1provided by MGI
Primary source: MGI:MGI:101876
See related: Ensembl:ENSMUSG00000055320 AllianceGenome:MGI:101876
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TEF-1; Tcf13; TEAD-1; mTEF-1; Gtrgeo5; 2610024B07Rik; B230114H05Rik
Summary: Enables DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including embryonic organ development; hippo signaling; and transition between fast and slow fiber. Located in nucleus. Part of TEAD-YAP complex. Is expressed in several structures, including central nervous system; early conceptus; embryo mesenchyme; genitourinary system; and tooth. Human ortholog(s) of this gene implicated in Sveinsson chorioretinal atrophy. Orthologous to human TEAD1 (TEA domain transcription factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in bladder adult (RPKM 16.6), heart adult (RPKM 14.4) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F1; 7 58.8 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (112278563..112505991)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (112679356..112906784)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Taz/Tead1 Promotes Alternative Macrophage Activation and Kidney Fibrosis via Transcriptional Upregulation of Smad3.
Title: Taz/Tead1 Promotes Alternative Macrophage Activation and Kidney Fibrosis via Transcriptional Upregulation of Smad3.
TEAD1, MYO7A and NDUFC2 are novel functional genes associated with glucose metabolism in BXD recombinant inbred population.
Title: TEAD1, MYO7A and NDUFC2 are novel functional genes associated with glucose metabolism in BXD recombinant inbred population.
Estrogen receptor activation remodels TEAD1 gene expression to alleviate hepatic steatosis.
Title: Estrogen receptor activation remodels TEAD1 gene expression to alleviate hepatic steatosis.
SUMOylation of TEAD1 Modulates the Mechanism of Pathological Cardiac Hypertrophy.
Title: SUMOylation of TEAD1 Modulates the Mechanism of Pathological Cardiac Hypertrophy.
TEAD1 is crucial for developmental myelination, Remak bundles, and functional regeneration of peripheral nerves.
Title: TEAD1 is crucial for developmental myelination, Remak bundles, and functional regeneration of peripheral nerves.
TEA domain transcription factor 1(TEAD1) induces cardiac fibroblasts cells remodeling through BRD4/Wnt4 pathway.
Title: TEA domain transcription factor 1(TEAD1) induces cardiac fibroblasts cells remodeling through BRD4/Wnt4 pathway.
Comparative expression analysis of TEADs and their splice variants in mouse embryonic stem cells.
Title: Comparative expression analysis of TEADs and their splice variants in mouse embryonic stem cells.
Unveiling E2F4, TEAD1 and AP-1 as regulatory transcription factors of the replicative senescence program by multi-omics analysis.
Title: Unveiling E2F4, TEAD1 and AP-1 as regulatory transcription factors of the replicative senescence program by multi-omics analysis.
TEAD1 protects against necroptosis in postmitotic cardiomyocytes through regulation of nuclear DNA-encoded mitochondrial genes.
Title: TEAD1 protects against necroptosis in postmitotic cardiomyocytes through regulation of nuclear DNA-encoded mitochondrial genes.
YAP1/TEAD1 upregulate platelet-derived growth factor receptor beta to promote vascular smooth muscle cell proliferation and neointima formation.
Title: YAP1/TEAD1 upregulate platelet-derived growth factor receptor beta to promote vascular smooth muscle cell proliferation and neointima formation.

Submit: New GeneRIF Correction See all GeneRIFs (42)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1) 1 citation
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tead1 (e-PCR), detects polymorphism
- UniSTS:463436

UniSTS:224609 (e-PCR)
- UniSTS:224609

PMC124275P5 (e-PCR)
- UniSTS:270463

D7Mit370 (e-PCR), detects polymorphism
- UniSTS:131268

Tead1 (e-PCR), detects polymorphism
- UniSTS:144596

NoName (e-PCR)
- UniSTS:235749

Tead1 (e-PCR), detects polymorphism
- UniSTS:548083

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to retinoic acid	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within embryonic heart tube morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryonic organ development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hippo signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hippo signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in hippo signaling	ISO Inferred from Sequence Orthology more info
involved_in hippo signaling	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within lateral mesoderm development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within notochord development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within paraxial mesoderm development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of stem cell population maintenance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within transition between fast and slow fiber	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of TEAD-YAP complex	IPI Inferred from Physical Interaction more info	PubMed
part_of TEAD-YAP complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription regulator complex	IC Inferred by Curator more info	PubMed
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transcriptional enhancer factor TEF-1

Names: NTEF-1; TCF-13; transcription factor 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001166584.2 → NP_001160056.2 transcriptional enhancer factor TEF-1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1), which results from the use of a non-AUG (AUU) translation initiation codon.

Source sequence(s)

AC104930, AK140307

Consensus CDS

CCDS52365.1

UniProtKB/TrEMBL

F6QIG2, F6TBI7

Related

ENSMUSP00000060671.11, ENSMUST00000059768.18

Conserved Domains (1) summary

smart00426
Location:30 → 97

TEA; TEA domain
NM_001166585.2 → NP_001160057.2 transcriptional enhancer factor TEF-1 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks two alternate in-frame exons in the 5' coding region compared to variant 1 and uses a non-AUG (AUU) start codon for translation initiation. The resulting isoform (3) lacks two internal protein segments compared to variant 1.

Source sequence(s)

AC104930, AK140307, BC060138

Consensus CDS

CCDS52367.1

UniProtKB/Swiss-Prot

P30051

UniProtKB/TrEMBL

F7B3M8

Related

ENSMUSP00000081755.7, ENSMUST00000084705.13

Conserved Domains (1) summary

smart00426
Location:30 → 97

TEA; TEA domain
NM_009346.4 → NP_033372.2 transcriptional enhancer factor TEF-1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1 and uses a non-AUG (AUU) start codon for translation initiation. The resulting isoform (2) lacks an internal protein segment compared to isoform 1.

Source sequence(s)

AC104930, AK140307, AK148375

Consensus CDS

CCDS52366.1

UniProtKB/TrEMBL

F6ZIM6, F7B3M8

Related

ENSMUSP00000159345.2, ENSMUST00000239404.2

Conserved Domains (1) summary

smart00426
Location:30 → 97

TEA; TEA domain