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    ZNF320 zinc finger protein 320 [ Homo sapiens (human) ]

    Gene ID: 162967, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF320provided by HGNC
    Official Full Name
    zinc finger protein 320provided by HGNC
    Primary source
    HGNC:HGNC:13842
    See related
    Ensembl:ENSG00000182986 MIM:606427; AllianceGenome:HGNC:13842
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZFPL
    Summary
    ZNF320 encodes a Kruppel-like zinc finger protein. Members of this protein family are involved in activation or repression of transcription.[supplied by OMIM, Jul 2002]
    Expression
    Ubiquitous expression in urinary bladder (RPKM 3.5), thyroid (RPKM 3.3) and 25 other tissues See more
    Orthologs
    all
    NEW
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    Genomic context

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    See ZNF320 in Genome Data Viewer
    Location:
    19q13.41
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (52859491..52904320, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (55943802..55989230, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (53362744..53400947, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 600 Neighboring gene zinc finger protein 28 Neighboring gene PABPN1 pseudogene 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53324831-53325332 Neighboring gene zinc finger protein 468 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15057 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:53379555-53380056 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15058 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15059 Neighboring gene zinc finger protein 888 Neighboring gene ZNF816-ZNF321P readthrough Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53425609-53426342 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53426343-53427074 Neighboring gene ZNF888 antisense RNA 1 Neighboring gene zinc finger protein 321, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53445795-53446619

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. ZNF320 is a hypomethylated prognostic biomarker involved in immune infiltration of hepatocellular carcinoma and associated with cell cycle. Zhen J, et al. Aging (Albany NY), 2022 Oct 26. PMID 36287187, Free PMC Article
    2. A novel member of the WD-repeat gene family, WDR11, maps to the 10q26 region and is disrupted by a chromosome translocation in human glioblastoma cells. Chernova OB, et al. Oncogene, 2001 Aug 30. PMID 11536051
    3. Genome-wide association study of Alzheimer's disease with psychotic symptoms. Hollingworth P, et al. Mol Psychiatry, 2012 Dec. PMID 22005930, Free PMC Article
    4. Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells. Chang YJ, et al. Int J Mol Sci, 2023 Jun 6. PMID 37372979, Free PMC Article
    5. N(6)-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation. Cheng Y, et al. Cancer Cell, 2021 Jul 12. PMID 34048709, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZNF320 is a hypomethylated prognostic biomarker involved in immune infiltration of hepatocellular carcinoma and associated with cell cycle.
      Title: ZNF320 is a hypomethylated prognostic biomarker involved in immune infiltration of hepatocellular carcinoma and associated with cell cycle.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of Alzheimer's disease with psychotic symptoms.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp686G16228

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 320
    Names
    zinc finger gene 320
    zinc finger protein like

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001351773.2 → NP_001338702.1  zinc finger protein 320 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same protein (isoform 1).
      Source sequence(s)
      AC010487, AI344388, AK096348, BC131555, DA025391, DA742339
      Consensus CDS
      CCDS33095.1
      UniProtKB/Swiss-Prot
      A2RRD8, Q8NDR6
      Related
      ENSP00000375660.2, ENST00000391781.6
      Conserved Domains (4) summary
      COG5048
      Location:147 → 483
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:25 → 216
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:303 → 323
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box

    2. NM_001351774.2 → NP_001338703.1  zinc finger protein 320 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same protein (isoform 1).
      Source sequence(s)
      AC010487, AI344388, AK096348, BC105738, BC131555, DA742339, DA852671
      Consensus CDS
      CCDS33095.1
      UniProtKB/Swiss-Prot
      A2RRD8, Q8NDR6
      Related
      ENSP00000506814.1, ENST00000682928.1
      Conserved Domains (4) summary
      COG5048
      Location:147 → 483
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:25 → 216
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:303 → 323
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box

    3. NM_001351775.2 → NP_001338704.1  zinc finger protein 320 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same protein (isoform 1).
      Source sequence(s)
      AC010487, AI344388, AK096348, BC105738, BC131555, DA742339, DA852671
      Consensus CDS
      CCDS33095.1
      UniProtKB/Swiss-Prot
      A2RRD8, Q8NDR6
      Conserved Domains (4) summary
      COG5048
      Location:147 → 483
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:25 → 216
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:303 → 323
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box

    4. NM_001351776.2 → NP_001338705.1  zinc finger protein 320 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same protein (isoform 1).
      Source sequence(s)
      AC010487, AI344388, AK096348, BC131555, DA742339, DA852671
      Consensus CDS
      CCDS33095.1
      UniProtKB/Swiss-Prot
      A2RRD8, Q8NDR6
      Conserved Domains (4) summary
      COG5048
      Location:147 → 483
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:25 → 216
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:303 → 323
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box

    5. NM_001351777.2 → NP_001338706.1  zinc finger protein 320 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) contains two alternate exons in the 3' coding region, including an alternate terminal exon, compared to variant 1. The encoded isoform (2) is significantly shorter, and contains a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC008813, AC010487, CA425481, DA025391, DA415801, DA742339, DC418794
      Consensus CDS
      CCDS92678.1
      UniProtKB/TrEMBL
      A0A669KBJ2
      Conserved Domains (1) summary
      pfam01352
      Location:7 → 48
      KRAB; KRAB box

    6. NM_001387570.1 → NP_001374499.1  zinc finger protein 320 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008813, AC010487
      Consensus CDS
      CCDS92678.1
      UniProtKB/TrEMBL
      A0A669KBJ2
      Related
      ENSP00000501288.1, ENST00000594408.3
      Conserved Domains (1) summary
      pfam01352
      Location:7 → 48
      KRAB; KRAB box

    7. NM_001387571.1 → NP_001374500.1  zinc finger protein 320 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008813, AC010487
      Consensus CDS
      CCDS92678.1
      UniProtKB/TrEMBL
      A0A669KBJ2
      Related
      ENSP00000500974.1, ENST00000673631.1
      Conserved Domains (1) summary
      pfam01352
      Location:7 → 48
      KRAB; KRAB box

    8. NM_001387572.1 → NP_001374501.1  zinc finger protein 320 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC010487
      Consensus CDS
      CCDS33095.1
      UniProtKB/Swiss-Prot
      A2RRD8, Q8NDR6
      Related
      ENSP00000473091.1, ENST00000595635.5
      Conserved Domains (4) summary
      COG5048
      Location:147 → 483
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:25 → 216
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:303 → 323
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box

    9. NM_001387573.1 → NP_001374502.1  zinc finger protein 320 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC010487
      Consensus CDS
      CCDS33095.1
      UniProtKB/Swiss-Prot
      A2RRD8, Q8NDR6
      Conserved Domains (4) summary
      COG5048
      Location:147 → 483
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:25 → 216
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:303 → 323
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box

    10. NM_001387574.1 → NP_001374503.1  zinc finger protein 320 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC010487
      Consensus CDS
      CCDS33095.1
      UniProtKB/Swiss-Prot
      A2RRD8, Q8NDR6
      Conserved Domains (4) summary
      COG5048
      Location:147 → 483
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:25 → 216
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:303 → 323
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box

    11. NM_001387575.1 → NP_001374504.1  zinc finger protein 320 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC010487
      Consensus CDS
      CCDS33095.1
      UniProtKB/Swiss-Prot
      A2RRD8, Q8NDR6
      Conserved Domains (4) summary
      COG5048
      Location:147 → 483
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:25 → 216
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:303 → 323
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box

    12. NM_001387576.1 → NP_001374505.1  zinc finger protein 320 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC010487
      Consensus CDS
      CCDS33095.1
      UniProtKB/Swiss-Prot
      A2RRD8, Q8NDR6
      Conserved Domains (4) summary
      COG5048
      Location:147 → 483
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:25 → 216
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:303 → 323
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box

    13. NM_001387577.1 → NP_001374506.1  zinc finger protein 320 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC010487
      Consensus CDS
      CCDS33095.1
      UniProtKB/Swiss-Prot
      A2RRD8, Q8NDR6
      Conserved Domains (4) summary
      COG5048
      Location:147 → 483
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:25 → 216
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:303 → 323
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box

    14. NM_207333.4 → NP_997216.2  zinc finger protein 320 isoform 1

      See identical proteins and their annotated locations for NP_997216.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1-5 encode the same protein (isoform 1).
      Source sequence(s)
      AC010487, AI344388, AK096348, BC131555, DA025391, DA742339
      Consensus CDS
      CCDS33095.1
      UniProtKB/Swiss-Prot
      A2RRD8, Q8NDR6
      Conserved Domains (4) summary
      COG5048
      Location:147 → 483
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:25 → 216
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:303 → 323
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      52859491..52904320 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024451397.2 → XP_024307165.1  zinc finger protein 320 isoform X2

      Conserved Domains (3) summary
      sd00017
      Location:155 → 175
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box
      pfam13465
      Location:168 → 191
      zf-H2C2_2; Zinc-finger double domain

    2. XM_047438310.1 → XP_047294266.1  zinc finger protein 320 isoform X2

    3. XM_047438309.1 → XP_047294265.1  zinc finger protein 320 isoform X2

    4. XM_024451396.2 → XP_024307164.1  zinc finger protein 320 isoform X2

      Conserved Domains (3) summary
      sd00017
      Location:155 → 175
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box
      pfam13465
      Location:168 → 191
      zf-H2C2_2; Zinc-finger double domain

    5. XM_047438305.1 → XP_047294261.1  zinc finger protein 320 isoform X1

      UniProtKB/Swiss-Prot
      A2RRD8, Q8NDR6

    6. XM_047438308.1 → XP_047294264.1  zinc finger protein 320 isoform X1

      UniProtKB/Swiss-Prot
      A2RRD8, Q8NDR6

    7. XM_047438306.1 → XP_047294262.1  zinc finger protein 320 isoform X1

      UniProtKB/Swiss-Prot
      A2RRD8, Q8NDR6

    8. XM_047438302.1 → XP_047294258.1  zinc finger protein 320 isoform X1

      UniProtKB/Swiss-Prot
      A2RRD8, Q8NDR6

    9. XM_047438301.1 → XP_047294257.1  zinc finger protein 320 isoform X1

      UniProtKB/Swiss-Prot
      A2RRD8, Q8NDR6

    10. XM_047438307.1 → XP_047294263.1  zinc finger protein 320 isoform X1

      UniProtKB/Swiss-Prot
      A2RRD8, Q8NDR6

    11. XM_047438300.1 → XP_047294256.1  zinc finger protein 320 isoform X1

      UniProtKB/Swiss-Prot
      A2RRD8, Q8NDR6

    12. XM_047438303.1 → XP_047294259.1  zinc finger protein 320 isoform X1

      UniProtKB/Swiss-Prot
      A2RRD8, Q8NDR6

    13. XM_047438304.1 → XP_047294260.1  zinc finger protein 320 isoform X1

      UniProtKB/Swiss-Prot
      A2RRD8, Q8NDR6

    RNA

    1. XR_002958275.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      55943802..55989230 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320050.1 → XP_054176025.1  zinc finger protein 320 isoform X2

    2. XM_054320049.1 → XP_054176024.1  zinc finger protein 320 isoform X2

    3. XM_054320048.1 → XP_054176023.1  zinc finger protein 320 isoform X2

    4. XM_054320047.1 → XP_054176022.1  zinc finger protein 320 isoform X2

    5. XM_054320043.1 → XP_054176018.1  zinc finger protein 320 isoform X1

      UniProtKB/Swiss-Prot
      A2RRD8, Q8NDR6

    6. XM_054320046.1 → XP_054176021.1  zinc finger protein 320 isoform X1

      UniProtKB/Swiss-Prot
      A2RRD8, Q8NDR6

    7. XM_054320041.1 → XP_054176016.1  zinc finger protein 320 isoform X1

      UniProtKB/Swiss-Prot
      A2RRD8, Q8NDR6

    8. XM_054320044.1 → XP_054176019.1  zinc finger protein 320 isoform X1

      UniProtKB/Swiss-Prot
      A2RRD8, Q8NDR6

    9. XM_054320040.1 → XP_054176015.1  zinc finger protein 320 isoform X1

      UniProtKB/Swiss-Prot
      A2RRD8, Q8NDR6

    10. XM_054320045.1 → XP_054176020.1  zinc finger protein 320 isoform X1

      UniProtKB/Swiss-Prot
      A2RRD8, Q8NDR6

    11. XM_054320039.1 → XP_054176014.1  zinc finger protein 320 isoform X1

      UniProtKB/Swiss-Prot
      A2RRD8, Q8NDR6

    12. XM_054320042.1 → XP_054176017.1  zinc finger protein 320 isoform X1

      UniProtKB/Swiss-Prot
      A2RRD8, Q8NDR6

    RNA

    1. XR_008485111.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_024200.2: Suppressed sequence

      Description
      NG_024200.2: This RefSeq was removed because there is now support for transcription in this region.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2RRD8.1 GenPept UniProtKB/Swiss-Prot:A2RRD8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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