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    Anxa2 annexin A2 [ Mus musculus (house mouse) ]

    Gene ID: 12306, updated on 13-Jan-2025

    Summary

    Official Symbol
    Anxa2provided by MGI
    Official Full Name
    annexin A2provided by MGI
    Primary source
    MGI:MGI:88246
    See related
    Ensembl:ENSMUSG00000032231 AllianceGenome:MGI:88246
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p36; Cal1h; PAP-IV
    Summary
    Predicted to enable several functions, including enzyme binding activity; enzyme inhibitor activity; and phospholipid binding activity. Involved in several processes, including mRNA transcription by RNA polymerase II; positive regulation of low-density lipoprotein particle clearance; and regulation of macromolecule metabolic process. Acts upstream of or within several processes, including collagen fibril organization; fibrinolysis; and response to activity. Located in several cellular components, including Schmidt-Lanterman incisure; basolateral plasma membrane; and myelin sheath adaxonal region. Part of RNA polymerase II transcription regulator complex and plasma membrane protein complex. Is active in cornified envelope. Is expressed in several structures, including central nervous system; dorsal aorta; oral epithelium; primary palate; and yolk sac blood vessel. Human ortholog(s) of this gene implicated in osteonecrosis. Orthologous to several human genes including ANXA2 (annexin A2). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in large intestine adult (RPKM 323.7), genital fat pad adult (RPKM 314.4) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Anxa2 in Genome Data Viewer
    Location:
    9 C; 9 38.58 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (69360978..69399074)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (69453683..69491792)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene purine-nucleoside phosphorylase pseudogene Neighboring gene ribosomal protein L7A pseudogene Neighboring gene microRNA 3109 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:69318859-69319214 Neighboring gene predicted gene, 57542 Neighboring gene predicted gene, 53538

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables S100 protein binding  
    enables S100 protein binding  
    enables bone sialoprotein binding  
    enables calcium ion binding  
    enables calcium-dependent phospholipid binding  
    enables calcium-dependent phospholipid binding  
    enables calcium-dependent phospholipid binding  
    enables calcium-dependent protein binding  
    enables cytoskeletal protein binding  
    enables identical protein binding  
    enables identical protein binding  
    enables phosphatidylinositol-4,5-bisphosphate binding  
    enables phosphatidylinositol-4,5-bisphosphate binding  
    enables phosphatidylserine binding  
    enables phospholipase A2 inhibitor activity  
    enables phospholipase A2 inhibitor activity  
    enables protease binding  
    enables protease binding  
    enables protein binding PubMed 
    enables serine-type endopeptidase inhibitor activity  
    enables serine-type endopeptidase inhibitor activity  
    enables small GTPase binding  
    Items 1 - 25 of 33
    Process Evidence Code Pubs
    acts_upstream_of_or_within angiogenesis PubMed 
    involved_in body fluid secretion  
    acts_upstream_of_or_within cell adhesion PubMed 
    acts_upstream_of_or_within cell-matrix adhesion PubMed 
    acts_upstream_of_or_within cellular response to acid chemical PubMed 
    acts_upstream_of_or_within collagen fibril organization PubMed 
    acts_upstream_of_or_within epithelial cell apoptotic process PubMed 
    acts_upstream_of_or_within fibrinolysis PubMed 
    acts_upstream_of_or_within lung development PubMed 
    involved_in mRNA transcription by RNA polymerase II PubMed 
    involved_in membrane raft assembly  
    involved_in negative regulation of low-density lipoprotein particle receptor catabolic process PubMed 
    involved_in negative regulation of receptor internalization  
    involved_in osteoclast development  
    acts_upstream_of_or_within positive regulation of binding PubMed 
    involved_in positive regulation of exocytosis PubMed 
    involved_in positive regulation of fibroblast proliferation  
    involved_in positive regulation of low-density lipoprotein particle clearance PubMed 
    involved_in positive regulation of low-density lipoprotein particle receptor binding PubMed 
    involved_in positive regulation of low-density lipoprotein receptor activity PubMed 
    involved_in positive regulation of plasma membrane repair PubMed 
    involved_in positive regulation of plasminogen activation  
    involved_in positive regulation of protein phosphorylation  
    involved_in positive regulation of receptor recycling PubMed 
    involved_in positive regulation of receptor-mediated endocytosis involved in cholesterol transport  
    involved_in positive regulation of receptor-mediated endocytosis involved in cholesterol transport PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of vacuole organization  
    involved_in positive regulation of vesicle fusion  
    involved_in protein localization to plasma membrane  
    involved_in regulation of neurogenesis PubMed 
    acts_upstream_of_or_within response to activity PubMed 
    involved_in vesicle budding from membrane  
    Items 1 - 25 of 33
    Items 1 - 20 of 57
    Component Evidence Code Pubs
    part_of AnxA2-p11 complex  
    part_of AnxA2-p11 complex  
    part_of PCSK9-AnxA2 complex  
    part_of PCSK9-AnxA2 complex  
    part_of RNA polymerase II transcription regulator complex PubMed 
    part_of RNA polymerase II transcription regulator complex  
    located_in Schmidt-Lanterman incisure PubMed 
    located_in basement membrane  
    located_in basolateral plasma membrane PubMed 
    located_in cell cortex  
    located_in cell junction PubMed 
    located_in cell surface PubMed 
    located_in cell surface  
    located_in collagen-containing extracellular matrix PubMed 
    is_active_in cornified envelope PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytosol PubMed 
    located_in cytosol  
    located_in cytosol  
    located_in early endosome PubMed 
    located_in endosome  
    located_in extracellular exosome  
    located_in extracellular exosome  
    located_in extracellular space PubMed 
    located_in late endosome membrane  
    located_in late endosome membrane  
    located_in lipid droplet  
    located_in lipid droplet  
    located_in lysosomal membrane  
    located_in lysosomal membrane  
    located_in macropinosome  
    located_in melanosome  
    located_in membrane PubMed 
    located_in membrane PubMed 
    located_in membrane raft  
    colocalizes_with membrane raft  
    located_in membrane raft  
    located_in midbody  
    located_in midbody  
    located_in myelin sheath adaxonal region PubMed 
    located_in nuclear matrix PubMed 
    is_active_in nucleus  
    located_in perinuclear region of cytoplasm  
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane PubMed 
    part_of plasma membrane protein complex PubMed 
    part_of plasma membrane protein complex PubMed 
    part_of plasma membrane protein complex  
    part_of protein-containing complex  
    located_in ruffle  
    located_in sarcolemma PubMed 
    located_in stress fiber PubMed 
    located_in vesicle  
    is_active_in vesicle membrane  
    Items 1 - 20 of 57

    General protein information

    Preferred Names
    annexin A2
    Names
    33-kDa calcimedin
    33-kDa lymphocyte Ca<2+>- binding protein
    33kDa lymphocyte Ca<2+>- binding protein
    36-kDa calelectrin
    annexin II
    annexin-2
    calpactin I heavy chain
    calpactin-1 heavy chain
    chromobindin-8
    lipocortin II
    placental anticoagulant protein IV
    protein I

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001409577.1NP_001396506.1  annexin A2

      Status: VALIDATED

      Source sequence(s)
      CT009708
      UniProtKB/Swiss-Prot
      P07356
      UniProtKB/TrEMBL
      Q3UCD3, Q542G9
    2. NM_007585.4NP_031611.1  annexin A2

      See identical proteins and their annotated locations for NP_031611.1

      Status: VALIDATED

      Source sequence(s)
      CT009708
      Consensus CDS
      CCDS23316.1
      UniProtKB/Swiss-Prot
      P07356
      UniProtKB/TrEMBL
      Q3UCD3, Q542G9
      Related
      ENSMUSP00000034756.9, ENSMUST00000034756.15
      Conserved Domains (1) summary
      pfam00191
      Location:109174
      Annexin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      69360978..69399074
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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