Foxn4 forkhead box N4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Foxn4provided by MGI
Official Full Name: forkhead box N4provided by MGI
Primary source: MGI:MGI:2151057
See related: Ensembl:ENSMUSG00000042002 AllianceGenome:MGI:2151057
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific; chromatin binding activity; and cis-regulatory region sequence-specific DNA binding activity. Involved in neural retina development; positive regulation of transcription by RNA polymerase II; and ventral spinal cord interneuron fate commitment. Acts upstream of or within neuron fate commitment. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; eye; metanephros; and respiratory system. Orthologous to human FOXN4 (forkhead box N4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in CNS E11.5 (RPKM 1.7), ovary adult (RPKM 0.4) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 55.99 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (114392225..114412486, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (114254164..114274418, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Foxn4 is a temporal identity factor conferring mid/late-early retinal competence and involved in retinal synaptogenesis.In early embryonic retinas, Foxn4 inactivation causes down-regulation of photoreceptor marker genes and decreased photoreceptor generation but increased RGC production, whereas its overexpression has the opposite effect.
Title: Foxn4 is a temporal identity factor conferring mid/late-early retinal competence and involved in retinal synaptogenesis.
the mosaic expression of Foxn4 and proneural factors may serve as the trigger to initiate asymmetric Dll4-Notch and subsequent BMP/TGFbeta signaling events required for neuronal diversity in the V2 domain.
Title: Asymmetric activation of Dll4-Notch signaling by Foxn4 and proneural factors activates BMP/TGFβ signaling to specify V2b interneurons in the spinal cord.
Mouse Foxn4 transfection reduced by 2.7-fold the basal level of Tbx2 promoter transcription, but deletion of the AD domain increased transcription showing that this domain might be a transregulatory domain.
Title: A regulatory domain is required for Foxn4 activity during retinogenesis.
Foxn4 has an intrinsic activity to suppress the alternative photoreceptor cell fates of early retinal progenitors by selectively activating Dll4-Notch signaling.
Title: Forkhead box N4 (Foxn4) activates Dll4-Notch signaling to suppress photoreceptor cell fates of early retinal progenitors.
Foxn4 may have a non-cell-autonomous role critical for alveologenesis during lung development.
Title: Foxn4 influences alveologenesis during lung development.
findings show that Foxn4 is required for proper outgrowth of retinal ganglion cell (RGC) axons in vivo, suggesting a role for an amacrine cell-RGC interaction in axon growth
Title: Foxn4 is required for retinal ganglion cell distal axon patterning.
Foxn4 induces expression of delta-like 4 (Dll4) and Mash1 (Ascl1). Dll4 then signals through Notch1 to subdivide the p2 progenitor pool in the ventral spinal cord.
Title: A regulatory network involving Foxn4, Mash1 and delta-like 4/Notch1 generates V2a and V2b spinal interneurons from a common progenitor pool.
Foxn4 acts synergistically with Mash1 to specify subtype identity of V2 interneurons in the spinal cord.
Title: Foxn4 acts synergistically with Mash1 to specify subtype identity of V2 interneurons in the spinal cord.
expressed during neural development in the retina, the ventral hindbrain and spinal cord and dorsal midbrain
Title: Foxn4--a new member of the forkhead gene family is expressed in the retina.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

General gene information

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Markers

Foxn4 (e-PCR), detects polymorphism
- UniSTS:547228

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within amacrine cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in amacrine cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in atrioventricular canal development	ISS Inferred from Sequence or Structural Similarity more info
involved_in heart looping	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within neuron fate commitment	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of heart contraction	ISS Inferred from Sequence or Structural Similarity more info
involved_in retina layer formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventral spinal cord interneuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventral spinal cord interneuron fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: forkhead box protein N4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.