Wt1 WT1 transcription factor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wt1provided by MGI
Official Full Name: WT1 transcription factorprovided by MGI
Primary source: MGI:MGI:98968
See related: Ensembl:ENSMUSG00000016458 AllianceGenome:MGI:98968
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Wt-1; D630046I19Rik
Summary: This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It plays an essential role in the normal development of the urogenital system, and the orthologous human gene is mutated in a small subset of patients with Wilm's tumors. Alternative splicing has been noted for this gene, however, the full-length nature of these variants is not known. The mRNA for this gene has been shown to initiate translation from non-AUG (CUG) and AUG translation start sites, resulting in different isoforms. [provided by RefSeq, Apr 2013]
Expression: Biased expression in ovary adult (RPKM 46.4), subcutaneous fat pad adult (RPKM 17.1) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E3; 2 55.06 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (104956874..105003959)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (105126529..105173614)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Obesity-related glomerulopathy is associated with elevated WT1 expression in podocytes.
Title: Obesity-related glomerulopathy is associated with elevated WT1 expression in podocytes.
Inhibition of transcriptional coactivator YAP Impairs the expression and function of transcription factor WT1 in diabetic podocyte injury.
Title: Inhibition of transcriptional coactivator YAP Impairs the expression and function of transcription factor WT1 in diabetic podocyte injury.
The -KTS splice variant of WT1 is essential for ovarian determination in mice.
Title: The -KTS splice variant of WT1 is essential for ovarian determination in mice.
Multigenerational paternal obesity enhances the susceptibility to male subfertility in offspring via Wt1 N6-methyladenosine modification.
Title: Multigenerational paternal obesity enhances the susceptibility to male subfertility in offspring via Wt1 N6-methyladenosine modification.
WT1 regulates expression of DNA repair gene Neil3 during nephrogenesis.
Title: WT1 regulates expression of DNA repair gene Neil3 during nephrogenesis.
The functions of Wt1 in mouse gonad development and somatic cells differentiationdagger.
Title: The functions of Wt1 in mouse gonad development and somatic cells differentiation†.
Deletion of Wt1 during early gonadogenesis leads to differences of sex development in male and female adult mice.
Title: Deletion of Wt1 during early gonadogenesis leads to differences of sex development in male and female adult mice.
hnRNPU in Sertoli cells cooperates with WT1 and is essential for testicular development by modulating transcriptional factors Sox8/9.
Title: hnRNPU in Sertoli cells cooperates with WT1 and is essential for testicular development by modulating transcriptional factors Sox8/9.
Brain-specific Wt1 deletion leads to depressive-like behaviors in mice via the recruitment of Tet2 to modulate Epo expression.
Title: Brain-specific Wt1 deletion leads to depressive-like behaviors in mice via the recruitment of Tet2 to modulate Epo expression.
Loss of sphingosine kinase 2 enhances Wilm's tumor suppressor gene 1 and nephrin expression in podocytes and protects from streptozotocin-induced podocytopathy and albuminuria in mice.
Title: Loss of sphingosine kinase 2 enhances Wilm's tumor suppressor gene 1 and nephrin expression in podocytes and protects from streptozotocin-induced podocytopathy and albuminuria in mice.

Submit: New GeneRIF Correction See all GeneRIFs (153)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Targeted (19) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Wt1 (e-PCR), detects polymorphism
- UniSTS:265240

Wt1 (e-PCR), detects polymorphism
- UniSTS:464700

Wt1 (e-PCR), detects polymorphism
- UniSTS:464701

Wt1 (e-PCR), detects polymorphism
- UniSTS:464702

PMC133868P1 (e-PCR)
- UniSTS:270673

Wt1 (e-PCR), detects polymorphism
- UniSTS:545875

PMC186395P1 (e-PCR)
- UniSTS:271706

WT1-2 (e-PCR)
- UniSTS:254075

NoName (e-PCR)
- UniSTS:548223

Wt1 (e-PCR), detects polymorphism
- UniSTS:144788

GDB:371627 (e-PCR)
- UniSTS:156868

GDB:371630 (e-PCR)
- UniSTS:156869

WT (e-PCR)
- UniSTS:253946

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables C2H2 zinc finger domain binding	ISO Inferred from Sequence Orthology more info
enables C2H2 zinc finger domain binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded methylated DNA binding	ISO Inferred from Sequence Orthology more info
enables double-stranded methylated DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables hemi-methylated DNA-binding	ISO Inferred from Sequence Orthology more info
enables hemi-methylated DNA-binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in RNA splicing	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within Sertoli cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adrenal cortex formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adrenal gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adrenal gland development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in branching involved in ureteric bud morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in branching involved in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within camera-type eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac muscle cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to gonadotropin stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to gonadotropin stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in coronary vasculature development	TAS Traceable Author Statement more info	PubMed
involved_in diaphragm development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within flagellated sperm motility	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glomerular basement membrane development	ISO Inferred from Sequence Orthology more info
involved_in glomerulus development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glomerulus development	ISO Inferred from Sequence Orthology more info
involved_in gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart development	ISO Inferred from Sequence Orthology more info
involved_in kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in kidney development	ISO Inferred from Sequence Orthology more info
involved_in male genitalia development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within male gonad development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within male gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of mesenchymal cell apoptotic process involved in metanephros development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesenchymal to epithelial transition	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mesonephros development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in metanephric S-shaped body morphogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in metanephric S-shaped body morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in metanephric S-shaped body morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in metanephric comma-shaped body morphogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in metanephric mesenchyme development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within metanephros development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in metanephros development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of female gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_positive_effect negative regulation of gene expression via chromosomal CpG island methylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of mesenchymal cell apoptotic process involved in metanephros development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of metanephric glomerular mesangial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info	PubMed
involved_in negative regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in podocyte development	IEP Inferred from Expression Pattern more info	PubMed
involved_in podocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heart growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of male gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of metanephric ureteric bud development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in posterior mesonephric tubule development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of animal organ formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within seminiferous tubule development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sex determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sex determination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within single fertilization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in thorax and anterior abdomen determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ureteric bud development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vasculogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in visceral serous pericardium development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in visceral serous pericardium development	ISO Inferred from Sequence Orthology more info
involved_in visceral serous pericardium development	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear speck	TAS Traceable Author Statement more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: Wilms tumor protein homolog

Names: Wilms tumor 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_144783.2 → NP_659032.3 Wilms tumor protein homolog

Status: REVIEWED

Source sequence(s)

AL512584, BG087452, DQ537939

Consensus CDS

CCDS16496.2

UniProtKB/TrEMBL

F6Y2T6

Related

ENSMUSP00000117891.2, ENSMUST00000143043.8

Conserved Domains (4) summary

COG5048
Location:381 → 509

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:396 → 415

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam02165
Location:69 → 389

WT1; Wilm's tumour protein

pfam13465
Location:438 → 462

zf-H2C2_2; Zinc-finger double domain