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    Ubac2 ubiquitin associated domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 68889, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ubac2provided by MGI
    Official Full Name
    ubiquitin associated domain containing 2provided by MGI
    Primary source
    MGI:MGI:1916139
    See related
    Ensembl:ENSMUSG00000041765 AllianceGenome:MGI:1916139
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Phgdhl1; 1190008A14Rik
    Summary
    Predicted to enable serine-type endopeptidase activity. Involved in negative regulation of canonical Wnt signaling pathway. Predicted to be located in endoplasmic reticulum. Orthologous to human UBAC2 (UBA domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 38.1), testis adult (RPKM 37.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ubac2 in Genome Data Viewer
    Location:
    14 E5; 14 65.78 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (122115970..122258447)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (121878559..122021035)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene dedicator of cytokinesis 9 Neighboring gene STARR-positive B cell enhancer ABC_E7355 Neighboring gene STARR-positive B cell enhancer mm9_chr14:122197085-122197385 Neighboring gene STARR-positive B cell enhancer mm9_chr14:122197667-122197968 Neighboring gene STARR-positive B cell enhancer mm9_chr14:122223986-122224286 Neighboring gene STARR-seq mESC enhancer starr_37739 Neighboring gene RIKEN cDNA 1810041H14 gene Neighboring gene STARR-positive B cell enhancer ABC_E10843 Neighboring gene STARR-positive B cell enhancer mm9_chr14:122277628-122277929 Neighboring gene STARR-positive B cell enhancer ABC_E9906 Neighboring gene predicted gene 9395 Neighboring gene STARR-positive B cell enhancer ABC_E11585 Neighboring gene STARR-positive B cell enhancer mm9_chr14:122306628-122306928 Neighboring gene STARR-positive B cell enhancer mm9_chr14:122309024-122309325 Neighboring gene STARR-positive B cell enhancer ABC_E7358 Neighboring gene STARR-positive B cell enhancer mm9_chr14:122327665-122327966 Neighboring gene STARR-positive B cell enhancer ABC_E8579 Neighboring gene STARR-positive B cell enhancer mm9_chr14:122337770-122338071 Neighboring gene predicted gene, 46485 Neighboring gene STARR-positive B cell enhancer mm9_chr14:122364300-122364601 Neighboring gene G protein-coupled receptor 18 Neighboring gene G protein-coupled receptor 183 Neighboring gene STARR-positive B cell enhancer ABC_E8580 Neighboring gene STARR-positive B cell enhancer ABC_E4126 Neighboring gene STARR-positive B cell enhancer ABC_E4127 Neighboring gene STARR-positive B cell enhancer ABC_E8581 Neighboring gene predicted gene, 52103 Neighboring gene translocase of inner mitochondrial membrane 8A2 Neighboring gene STARR-positive B cell enhancer ABC_E5466 Neighboring gene RIKEN cDNA A330035P11 gene Neighboring gene STARR-positive B cell enhancer ABC_E5467 Neighboring gene transmembrane 9 superfamily member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mutagenesis of diploid mammalian genes by gene entrapment. Lin Q, et al. Nucleic Acids Res, 2006. PMID 17062627, Free PMC Article
    2. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
    3. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767
    4. LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling. Choi JH, et al. Science, 2019 May 10. PMID 31073040, Free PMC Article
    5. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of retrograde protein transport, ER to cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of retrograde protein transport, ER to cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein localization to endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-associated domain-containing protein 2
    Names
    UBA domain-containing protein 2
    phosphoglycerate dehydrogenase like 1
    phosphoglycerate dehydrogenase-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026861.2 → NP_081137.2  ubiquitin-associated domain-containing protein 2 precursor

      See identical proteins and their annotated locations for NP_081137.2

      Status: VALIDATED

      Source sequence(s)
      AK049109, BC017635, BY080555
      Consensus CDS
      CCDS37019.1
      UniProtKB/Swiss-Prot
      Q3TWC0, Q8R1K1
      Related
      ENSMUSP00000043245.6, ENSMUST00000039803.7
      Conserved Domains (1) summary
      cd14305
      Location:306 → 343
      UBA_UBAC2; UBA domain found in ubiquitin-associated domain-containing protein 2 (UBAC2) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      122115970..122258447
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519492.4 → XP_006519555.1  ubiquitin-associated domain-containing protein 2 isoform X1

      Conserved Domains (1) summary
      cd14305
      Location:290 → 327
      UBA_UBAC2; UBA domain found in ubiquitin-associated domain-containing protein 2 (UBAC2) and similar proteins

    2. XM_030247988.2 → XP_030103848.1  ubiquitin-associated domain-containing protein 2 isoform X2

      Conserved Domains (2) summary
      cd14305
      Location:123 → 160
      UBA_UBAC2; UBA domain found in ubiquitin-associated domain-containing protein 2 (UBAC2) and similar proteins
      TIGR00601
      Location:62 → 162
      rad23; UV excision repair protein Rad23

    RNA

    1. XR_004938442.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R1K1.1 GenPept UniProtKB/Swiss-Prot:Q8R1K1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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