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    NAAA N-acylethanolamine acid amidase [ Homo sapiens (human) ]

    Gene ID: 27163, updated on 27-Nov-2024

    Summary

    Official Symbol
    NAAAprovided by HGNC
    Official Full Name
    N-acylethanolamine acid amidaseprovided by HGNC
    Primary source
    HGNC:HGNC:736
    See related
    Ensembl:ENSG00000138744 MIM:607469; AllianceGenome:HGNC:736
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PLT; ASAHL
    Summary
    Enables DNA-binding transcription factor binding activity and hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides. Involved in several processes, including N-acylethanolamine metabolic process; N-acylphosphatidylethanolamine metabolic process; and sphingosine metabolic process. Located in lysosome and membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in prostate (RPKM 15.8), colon (RPKM 14.0) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See NAAA in Genome Data Viewer
    Location:
    4q21.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (75910655..75941013, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (79251154..79281501, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (76831808..76862166, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377284 Neighboring gene RNA, U2 small nuclear 16, pseudogene Neighboring gene protein phosphatase with EF-hand domain 2 Neighboring gene uncharacterized LOC105377285 Neighboring gene Sharpr-MPRA regulatory region 11706 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:76829825-76830747 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:76830748-76831669 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21623 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15483 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15484 Neighboring gene SDA1 domain containing 1 Neighboring gene SDAD1 antisense RNA 1 Neighboring gene C-X-C motif chemokine ligand 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in lysosomal lumen TAS
    Traceable Author Statement
    more info
     
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    N-acylethanolamine-hydrolyzing acid amidase
    Names
    ASAH-like protein
    acid ceramidase-like protein
    acylsphingosine deacylase NAAA
    NP_001035861.1
    NP_001350648.1
    NP_055250.2
    XP_005262978.1
    XP_005262980.1
    XP_005262981.1
    XP_006714243.1
    XP_011530154.1
    XP_011530156.1
    XP_016863517.1
    XP_016863518.1
    XP_016863519.1
    XP_047306023.1
    XP_054205659.1
    XP_054205660.1
    XP_054205661.1
    XP_054205662.1
    XP_054205663.1
    XP_054205664.1
    XP_054205665.1
    XP_054205666.1
    XP_054205667.1
    XP_054205668.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042402.2NP_001035861.1  N-acylethanolamine-hydrolyzing acid amidase isoform 2 precursor

      See identical proteins and their annotated locations for NP_001035861.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the C-terminus compared to isoform 1. Variants 2 and 3 both encode the same isoform (2).
      Source sequence(s)
      AB161353, AV723847, BM763257, M92449
      UniProtKB/Swiss-Prot
      Q02083
      Conserved Domains (2) summary
      cd01903
      Location:117323
      Ntn_AC_NAAA; AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also known as N-acylsphingosine amidohydrolase), and N-acylethanolamine-hydrolyzing acid amidase (NAAA). AC catalyzes the hydrolysis of ceramide to sphingosine and ...
      pfam15508
      Location:3291
      NAAA-beta; beta subunit of N-acylethanolamine-hydrolyzing acid amidase
    2. NM_001363719.2NP_001350648.1  N-acylethanolamine-hydrolyzing acid amidase isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the C-terminus compared to isoform 1. Variants 2 and 3 both encode the same isoform (2).
      Source sequence(s)
      AC110615
      Consensus CDS
      CCDS87233.1
      Related
      ENSP00000427641.1, ENST00000507956.5
      Conserved Domains (2) summary
      cd01903
      Location:117323
      Ntn_AC_NAAA; AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also known as N-acylsphingosine amidohydrolase), and N-acylethanolamine-hydrolyzing acid amidase (NAAA). AC catalyzes the hydrolysis of ceramide to sphingosine and ...
      pfam15508
      Location:3291
      NAAA-beta; beta subunit of N-acylethanolamine-hydrolyzing acid amidase
    3. NM_014435.4NP_055250.2  N-acylethanolamine-hydrolyzing acid amidase isoform 1 precursor

      See identical proteins and their annotated locations for NP_055250.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AB161353, BM682921, BM763257, DR156596, W47597
      Consensus CDS
      CCDS43239.1
      UniProtKB/Swiss-Prot
      Q02083, Q5KTF2, Q96EY2, Q9BRA8
      Related
      ENSP00000286733.4, ENST00000286733.9
      Conserved Domains (2) summary
      cd01903
      Location:117346
      Ntn_AC_NAAA; AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also known as N-acylsphingosine amidohydrolase), and N-acylethanolamine-hydrolyzing acid amidase (NAAA). AC catalyzes the hydrolysis of ceramide to sphingosine and ...
      pfam15508
      Location:32121
      NAAA-beta; beta subunit of N-acylethanolamine-hydrolyzing acid amidase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      75910655..75941013 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006714180.4XP_006714243.1  N-acylethanolamine-hydrolyzing acid amidase isoform X4

      Conserved Domains (2) summary
      cd01903
      Location:117333
      Ntn_AC_NAAA; AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also known as N-acylsphingosine amidohydrolase), and N-acylethanolamine-hydrolyzing acid amidase (NAAA). AC catalyzes the hydrolysis of ceramide to sphingosine and ...
      pfam15508
      Location:32121
      NAAA-beta; beta subunit of N-acylethanolamine-hydrolyzing acid amidase
    2. XM_005262924.4XP_005262981.1  N-acylethanolamine-hydrolyzing acid amidase isoform X8

      Conserved Domains (2) summary
      cd01903
      Location:117324
      Ntn_AC_NAAA; AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also known as N-acylsphingosine amidohydrolase), and N-acylethanolamine-hydrolyzing acid amidase (NAAA). AC catalyzes the hydrolysis of ceramide to sphingosine and ...
      pfam15508
      Location:32121
      NAAA-beta; beta subunit of N-acylethanolamine-hydrolyzing acid amidase
    3. XM_017008030.3XP_016863519.1  N-acylethanolamine-hydrolyzing acid amidase isoform X6

      Conserved Domains (2) summary
      cd01903
      Location:117323
      Ntn_AC_NAAA; AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also known as N-acylsphingosine amidohydrolase), and N-acylethanolamine-hydrolyzing acid amidase (NAAA). AC catalyzes the hydrolysis of ceramide to sphingosine and ...
      pfam15508
      Location:32121
      NAAA-beta; beta subunit of N-acylethanolamine-hydrolyzing acid amidase
    4. XM_005262923.4XP_005262980.1  N-acylethanolamine-hydrolyzing acid amidase isoform X7

      Conserved Domains (2) summary
      cd01903
      Location:117333
      Ntn_AC_NAAA; AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also known as N-acylsphingosine amidohydrolase), and N-acylethanolamine-hydrolyzing acid amidase (NAAA). AC catalyzes the hydrolysis of ceramide to sphingosine and ...
      pfam15508
      Location:32121
      NAAA-beta; beta subunit of N-acylethanolamine-hydrolyzing acid amidase
    5. XM_017008028.3XP_016863517.1  N-acylethanolamine-hydrolyzing acid amidase isoform X1

      UniProtKB/Swiss-Prot
      Q02083, Q5KTF2, Q96EY2, Q9BRA8
      Conserved Domains (2) summary
      cd01903
      Location:117346
      Ntn_AC_NAAA; AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also known as N-acylsphingosine amidohydrolase), and N-acylethanolamine-hydrolyzing acid amidase (NAAA). AC catalyzes the hydrolysis of ceramide to sphingosine and ...
      pfam15508
      Location:32121
      NAAA-beta; beta subunit of N-acylethanolamine-hydrolyzing acid amidase
    6. XM_047450067.1XP_047306023.1  N-acylethanolamine-hydrolyzing acid amidase isoform X6

    7. XM_011531854.4XP_011530156.1  N-acylethanolamine-hydrolyzing acid amidase isoform X9

      Conserved Domains (2) summary
      cd01903
      Location:117323
      Ntn_AC_NAAA; AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also known as N-acylsphingosine amidohydrolase), and N-acylethanolamine-hydrolyzing acid amidase (NAAA). AC catalyzes the hydrolysis of ceramide to sphingosine and ...
      pfam15508
      Location:32121
      NAAA-beta; beta subunit of N-acylethanolamine-hydrolyzing acid amidase
    8. XM_011531852.4XP_011530154.1  N-acylethanolamine-hydrolyzing acid amidase isoform X3

      Conserved Domains (2) summary
      cd01903
      Location:117334
      Ntn_AC_NAAA; AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also known as N-acylsphingosine amidohydrolase), and N-acylethanolamine-hydrolyzing acid amidase (NAAA). AC catalyzes the hydrolysis of ceramide to sphingosine and ...
      pfam15508
      Location:32121
      NAAA-beta; beta subunit of N-acylethanolamine-hydrolyzing acid amidase
    9. XM_005262921.5XP_005262978.1  N-acylethanolamine-hydrolyzing acid amidase isoform X5

      Conserved Domains (2) summary
      cd01903
      Location:117334
      Ntn_AC_NAAA; AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also known as N-acylsphingosine amidohydrolase), and N-acylethanolamine-hydrolyzing acid amidase (NAAA). AC catalyzes the hydrolysis of ceramide to sphingosine and ...
      pfam15508
      Location:32121
      NAAA-beta; beta subunit of N-acylethanolamine-hydrolyzing acid amidase
    10. XM_017008029.3XP_016863518.1  N-acylethanolamine-hydrolyzing acid amidase isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      79251154..79281501 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054349687.1XP_054205662.1  N-acylethanolamine-hydrolyzing acid amidase isoform X4

    2. XM_054349692.1XP_054205667.1  N-acylethanolamine-hydrolyzing acid amidase isoform X8

    3. XM_054349690.1XP_054205665.1  N-acylethanolamine-hydrolyzing acid amidase isoform X6

    4. XM_054349691.1XP_054205666.1  N-acylethanolamine-hydrolyzing acid amidase isoform X7

    5. XM_054349684.1XP_054205659.1  N-acylethanolamine-hydrolyzing acid amidase isoform X1

      UniProtKB/Swiss-Prot
      Q02083, Q5KTF2, Q96EY2, Q9BRA8
    6. XM_054349689.1XP_054205664.1  N-acylethanolamine-hydrolyzing acid amidase isoform X6

    7. XM_054349693.1XP_054205668.1  N-acylethanolamine-hydrolyzing acid amidase isoform X9

    8. XM_054349686.1XP_054205661.1  N-acylethanolamine-hydrolyzing acid amidase isoform X3

    9. XM_054349688.1XP_054205663.1  N-acylethanolamine-hydrolyzing acid amidase isoform X5

    10. XM_054349685.1XP_054205660.1  N-acylethanolamine-hydrolyzing acid amidase isoform X2