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    ATG7 autophagy related 7 [ Homo sapiens (human) ]

    Gene ID: 10533, updated on 3-Dec-2024

    Summary

    Official Symbol
    ATG7provided by HGNC
    Official Full Name
    autophagy related 7provided by HGNC
    Primary source
    HGNC:HGNC:16935
    See related
    Ensembl:ENSG00000197548 MIM:608760; AllianceGenome:HGNC:16935
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GSA7; APG7L; SCAR31; APG7-LIKE
    Summary
    This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
    Expression
    Ubiquitous expression in ovary (RPKM 10.0), thyroid (RPKM 8.3) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ATG7 in Genome Data Viewer
    Location:
    3p25.3
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (11272397..11576353)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (11267348..11571596)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (11314083..11606126)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723663 Neighboring gene histamine receptor H1 Neighboring gene Sharpr-MPRA regulatory region 13806 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:11299925-11300126 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:11313687-11314278 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:11314279-11314868 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 4 pseudogene 4 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:11328313-11328445 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:11330264-11331463 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14061 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19429 Neighboring gene ribosomal protein L13a pseudogene 27 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:11405755-11406954 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:11521898-11522503 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:11574579-11575079 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:11586483-11587050 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:11587827-11588328 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:11588329-11588828 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:11616238-11617058 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:11624893-11625731 Neighboring gene CSTB pseudogene 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:11634691-11635222 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:11635223-11635753 Neighboring gene Sharpr-MPRA regulatory region 8254 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr3:11642749-11643347 and GRCh37_chr3:11643348-11643945 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:11650998-11651770 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19431 Neighboring gene vestigial like family member 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:11680477-11681428 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19432 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19433 Neighboring gene Sharpr-MPRA regulatory region 9131 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14062 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14063 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19434 Neighboring gene Sharpr-MPRA regulatory region 5418 Neighboring gene TAM41 mitochondrial translocator assembly and maintenance homolog Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:11826643-11827198 Neighboring gene FANCD2 pseudogene 2 Neighboring gene CYCS pseudogene 12

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Spinocerebellar ataxia, autosomal recessive 31
    MedGen: C5543627 OMIM: 619422 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Common variants in left/right asymmetry genes and pathways are associated with relative hand skill.
    EBI GWAS Catalog
    Discovery and refinement of loci associated with lipid levels.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of autophagy related 7 homolog (ATG7) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat The siRNA-mediated reduction of ATG7 protein reverses Torin-1-induced HIV-1 Tat degradation, suggesting ATG7 is involved in the lysosomal-mediated Tat degradation PubMed
    capsid gag Knockdown of autophagy factor ATG7 results in diminished levels of p24 yields in both primary monocyte- and U937-derived macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp434N0735

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables Atg12 activating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables Atg12 activating enzyme activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables Atg12 activating enzyme activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables Atg12 activating enzyme activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables Atg8 activating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in autophagosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in autophagy IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in autophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to hyperoxia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to nitrogen starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to starvation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitophagy IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in piecemeal microautophagy of the nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of protein modification process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within protein lipidation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein modification by small protein conjugation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of circadian rhythm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in axoneme ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in ficolin-1-rich granule lumen TAS
    Traceable Author Statement
    more info
     
    is_active_in phagophore assembly site IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in phagophore assembly site IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in secretory granule lumen TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    ubiquitin-like modifier-activating enzyme ATG7
    Names
    APG7 autophagy 7-like
    ATG12-activating enzyme E1 ATG7
    hAGP7
    ubiquitin-activating enzyme E1-like protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136031.3NP_001129503.2  ubiquitin-like modifier-activating enzyme ATG7 isoform b

      See identical proteins and their annotated locations for NP_001129503.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes isoform b.
      Source sequence(s)
      AC022001, AL122075, BC000091, DA177126
      Consensus CDS
      CCDS46752.1
      UniProtKB/TrEMBL
      B2RB57, B3KQM6
      Related
      ENSP00000347042.5, ENST00000354956.9
      Conserved Domains (1) summary
      cl25654
      Location:15675
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    2. NM_001144912.2NP_001138384.1  ubiquitin-like modifier-activating enzyme ATG7 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) encodes isoform c.
      Source sequence(s)
      AC022001, AK303694, AL122075, BC000091, DA177126
      Consensus CDS
      CCDS46753.1
      UniProtKB/TrEMBL
      B2RB57, B3KQM6
      Related
      ENSP00000412580.2, ENST00000446450.6
      Conserved Domains (3) summary
      cd01486
      Location:318616
      Apg7; Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an ...
      TIGR01381
      Location:15614
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
      pfam16420
      Location:13282
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    3. NM_001349232.2NP_001336161.1  ubiquitin-like modifier-activating enzyme ATG7 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (a). Variants 1, 4, 5, 6, and 7 all encode the same isoform (a).
      Source sequence(s)
      AC020750, AC022001, AC026185, AC083855
      Consensus CDS
      CCDS2605.1
      UniProtKB/Swiss-Prot
      B4E170, E9PB95, O95352, Q7L8L0, Q9BWP2, Q9UFH4
      UniProtKB/TrEMBL
      B2RB57, B3KQM6
      Related
      ENSP00000510336.1, ENST00000693202.1
      Conserved Domains (1) summary
      cl25654
      Location:15702
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    4. NM_001349233.2NP_001336162.1  ubiquitin-like modifier-activating enzyme ATG7 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variants 1, 4, 6, and 7, encodes the longest isoform (a).
      Source sequence(s)
      AC020750, AC022001, AC026185, AC083855
      Consensus CDS
      CCDS2605.1
      UniProtKB/Swiss-Prot
      B4E170, E9PB95, O95352, Q7L8L0, Q9BWP2, Q9UFH4
      UniProtKB/TrEMBL
      B2RB57, B3KQM6
      Related
      ENSP00000509725.1, ENST00000685771.1
      Conserved Domains (1) summary
      cl25654
      Location:15702
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    5. NM_001349234.2NP_001336163.1  ubiquitin-like modifier-activating enzyme ATG7 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variants 1, 4, 5, and 7, encodes the longest isoform (a).
      Source sequence(s)
      AC020750, AC022001, AC026185, AC083855
      Consensus CDS
      CCDS2605.1
      UniProtKB/Swiss-Prot
      B4E170, E9PB95, O95352, Q7L8L0, Q9BWP2, Q9UFH4
      UniProtKB/TrEMBL
      B2RB57, B3KQM6
      Conserved Domains (1) summary
      cl25654
      Location:15702
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    6. NM_001349235.2NP_001336164.1  ubiquitin-like modifier-activating enzyme ATG7 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variants 1, 4, 5, and 6, encodes the longest isoform (a).
      Source sequence(s)
      AC020750, AC022001, AC026185, AC083855
      Consensus CDS
      CCDS2605.1
      UniProtKB/Swiss-Prot
      B4E170, E9PB95, O95352, Q7L8L0, Q9BWP2, Q9UFH4
      UniProtKB/TrEMBL
      B2RB57, B3KQM6
      Conserved Domains (1) summary
      cl25654
      Location:15702
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    7. NM_001349236.2NP_001336165.1  ubiquitin-like modifier-activating enzyme ATG7 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) encodes isoform d.
      Source sequence(s)
      AC020750, AC022001, AC026185, AC083855
      UniProtKB/TrEMBL
      B2RB57, B3KQM6
      Conserved Domains (1) summary
      cl25654
      Location:15663
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    8. NM_001349237.2NP_001336166.1  ubiquitin-like modifier-activating enzyme ATG7 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) encodes isoform e.
      Source sequence(s)
      AC020750, AC022001, AC026185, AC083855
      UniProtKB/TrEMBL
      B2RB57, B3KQM6
      Conserved Domains (1) summary
      cl25654
      Location:15649
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    9. NM_001349238.2NP_001336167.1  ubiquitin-like modifier-activating enzyme ATG7 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) encodes isoform f.
      Source sequence(s)
      AC020750, AC022001, AC026185, AC083855
      Conserved Domains (1) summary
      cd01486
      Location:46371
      Apg7; Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an ...
    10. NM_006395.3NP_006386.1  ubiquitin-like modifier-activating enzyme ATG7 isoform a

      See identical proteins and their annotated locations for NP_006386.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), as well as variants 4, 5, 6, and 7, encodes the longest isoform (a).
      Source sequence(s)
      AC022001, AK075221, AL122075, BC000091, DA177126
      Consensus CDS
      CCDS2605.1
      UniProtKB/Swiss-Prot
      B4E170, E9PB95, O95352, Q7L8L0, Q9BWP2, Q9UFH4
      UniProtKB/TrEMBL
      B2RB57, B3KQM6
      Related
      ENSP00000346437.3, ENST00000354449.7
      Conserved Domains (1) summary
      cl25654
      Location:15702
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      11272397..11576353
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017005548.2XP_016861037.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X4

      UniProtKB/TrEMBL
      B2RB57, B3KQM6
      Conserved Domains (3) summary
      cd01486
      Location:357682
      Apg7; Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an ...
      TIGR01381
      Location:15697
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
      pfam16420
      Location:13321
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    2. XM_017005551.2XP_016861040.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X10

      UniProtKB/TrEMBL
      B2RB57, B3KQM6
    3. XM_047447304.1XP_047303260.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X13

      UniProtKB/TrEMBL
      B2RB57, B3KQM6
    4. XM_047447296.1XP_047303252.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X1

      UniProtKB/TrEMBL
      B2RB57, B3KQM6
    5. XM_011533277.4XP_011531579.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X1

      See identical proteins and their annotated locations for XP_011531579.1

      UniProtKB/TrEMBL
      B2RB57, B3KQM6
      Conserved Domains (1) summary
      TIGR01381
      Location:15693
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
    6. XM_006712932.5XP_006712995.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X1

      See identical proteins and their annotated locations for XP_006712995.1

      UniProtKB/TrEMBL
      B2RB57, B3KQM6
      Conserved Domains (1) summary
      TIGR01381
      Location:15693
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
    7. XM_006712931.5XP_006712994.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X1

      See identical proteins and their annotated locations for XP_006712994.1

      UniProtKB/TrEMBL
      B2RB57, B3KQM6
      Conserved Domains (1) summary
      TIGR01381
      Location:15693
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
    8. XM_017005543.2XP_016861032.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X7

      UniProtKB/TrEMBL
      B2RB57, B3KQM6
      Conserved Domains (3) summary
      cd01486
      Location:357655
      Apg7; Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an ...
      TIGR01381
      Location:15666
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
      pfam16420
      Location:13321
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    9. XM_047447301.1XP_047303257.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X8

      UniProtKB/TrEMBL
      B2RB57, B3KQM6
    10. XM_047447303.1XP_047303259.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X12

      UniProtKB/TrEMBL
      B2RB57, B3KQM6
    11. XM_047447294.1XP_047303250.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X5

      UniProtKB/TrEMBL
      B2RB57, B3KQM6
    12. XM_047447302.1XP_047303258.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X11

      UniProtKB/TrEMBL
      B2RB57, B3KQM6
    13. XM_047447305.1XP_047303261.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X14

      UniProtKB/TrEMBL
      B2RB57, B3KQM6
    14. XM_047447293.1XP_047303249.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X3

      UniProtKB/TrEMBL
      B2RB57, B3KQM6
    15. XM_047447300.1XP_047303256.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X6

      UniProtKB/TrEMBL
      B2RB57, B3KQM6
    16. XM_047447306.1XP_047303262.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X15

      UniProtKB/TrEMBL
      B2RB57, B3KQM6
    17. XM_024453312.2XP_024309080.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X2

      UniProtKB/TrEMBL
      B2RB57, B3KQM6
      Conserved Domains (1) summary
      cl25654
      Location:15694
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    18. XM_017005550.2XP_016861039.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X9

      UniProtKB/TrEMBL
      B2RB57, B3KQM6
    19. XM_047447298.1XP_047303254.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X1

      UniProtKB/TrEMBL
      B2RB57, B3KQM6
    20. XM_047447295.1XP_047303251.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X1

      UniProtKB/TrEMBL
      B2RB57, B3KQM6
    21. XM_047447299.1XP_047303255.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X1

      UniProtKB/TrEMBL
      B2RB57, B3KQM6
    22. XM_047447297.1XP_047303253.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X1

      UniProtKB/TrEMBL
      B2RB57, B3KQM6
    23. XM_017005542.2XP_016861031.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X1

      UniProtKB/TrEMBL
      B2RB57, B3KQM6
      Conserved Domains (1) summary
      TIGR01381
      Location:15693
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
    24. XM_047447307.1XP_047303263.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X16

    25. XM_047447308.1XP_047303264.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X17

    26. XM_047447309.1XP_047303265.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X18

    RNA

    1. XR_007095622.1 RNA Sequence

    2. XR_007095623.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      11267348..11571596
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344946.1XP_054200921.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X4

      UniProtKB/TrEMBL
      B2RB57, B3KQM6
    2. XM_054344952.1XP_054200927.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X10

      UniProtKB/TrEMBL
      B2RB57, B3KQM6
    3. XM_054344955.1XP_054200930.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X13

      UniProtKB/TrEMBL
      B2RB57, B3KQM6
    4. XM_054344939.1XP_054200914.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X1

      UniProtKB/TrEMBL
      B2RB57, B3KQM6
    5. XM_054344954.1XP_054200929.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X12

      UniProtKB/TrEMBL
      B2RB57, B3KQM6
    6. XM_054344948.1XP_054200923.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X5

      UniProtKB/TrEMBL
      B2RB57, B3KQM6
    7. XM_054344953.1XP_054200928.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X11

      UniProtKB/TrEMBL
      B2RB57, B3KQM6
    8. XM_054344956.1XP_054200931.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X14

      UniProtKB/TrEMBL
      B2RB57, B3KQM6
    9. XM_054344947.1XP_054200922.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X20

      UniProtKB/TrEMBL
      B2RB57, B3KQM6
    10. XM_054344950.1XP_054200925.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X21

      UniProtKB/TrEMBL
      B2RB57, B3KQM6
    11. XM_054344942.1XP_054200917.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X19

      UniProtKB/TrEMBL
      B2RB57, B3KQM6
    12. XM_054344943.1XP_054200918.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X19

      UniProtKB/TrEMBL
      B2RB57, B3KQM6
    13. XM_054344938.1XP_054200913.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X19

      UniProtKB/TrEMBL
      B2RB57, B3KQM6
    14. XM_054344949.1XP_054200924.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X6

      UniProtKB/TrEMBL
      B2RB57, B3KQM6
    15. XM_054344957.1XP_054200932.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X15

      UniProtKB/TrEMBL
      B2RB57, B3KQM6
    16. XM_054344951.1XP_054200926.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X9

      UniProtKB/TrEMBL
      B2RB57, B3KQM6
    17. XM_054344940.1XP_054200915.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X2

      UniProtKB/TrEMBL
      B2RB57, B3KQM6
    18. XM_054344941.1XP_054200916.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X19

      UniProtKB/TrEMBL
      B2RB57, B3KQM6
    19. XM_054344944.1XP_054200919.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X19

      UniProtKB/TrEMBL
      B2RB57, B3KQM6
    20. XM_054344945.1XP_054200920.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X19

      UniProtKB/TrEMBL
      B2RB57, B3KQM6
    21. XM_054344958.1XP_054200933.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X22

    22. XM_054344959.1XP_054200934.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X17

    23. XM_054344960.1XP_054200935.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X23

    RNA

    1. XR_008486628.1 RNA Sequence

    2. XR_008486629.1 RNA Sequence