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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_008150.2 RefSeqGene
- Range
-
5047..59124
- Download
- GenBank, FASTA, Sequence Viewer (Graphics), LRG_302
mRNA and Protein(s)
-
NM_001005735.2 → NP_001005735.1 serine/threonine-protein kinase Chk2 isoform c
See identical proteins and their annotated locations for NP_001005735.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) contains an alternate in-frame exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is longer compared to isoform a.
- Source sequence(s)
-
AW778747, AY551297, BM838597
- Consensus CDS
-
CCDS33629.1
- UniProtKB/TrEMBL
-
A8JZZ5
- Related
- ENSP00000372023.2, ENST00000382580.6
- Conserved Domains (2) summary
-
- cd00060
Location:156 → 244
- FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
- cd14084
Location:256 → 529
- STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2
-
NM_001257387.2 → NP_001244316.1 serine/threonine-protein kinase Chk2 isoform d
See identical proteins and their annotated locations for NP_001244316.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) contains an alternate exon compared to variant 1, that causes a frameshift. The resulting isoform (d) is shorter at the N-terminus compared to isoform a.
- Source sequence(s)
-
AF217975
- UniProtKB/TrEMBL
-
A0A087X102
- Conserved Domains (2) summary
-
- smart00220
Location:3 → 265
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- cd14084
Location:1 → 265
- STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2
-
NM_001349956.2 → NP_001336885.1 serine/threonine-protein kinase Chk2 isoform e
Status: REVIEWED
- Description
- Transcript Variant: This variant (5) lacks an exon, and contains an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) [is shorter/has a distinct C-terminus], compared to isoform a. The resulting isoform (e) has the same N- and C-termini but is shorter compared to isoform a.
- Source sequence(s)
-
AF096279, AK290754, AW778747, BX393617
- Consensus CDS
-
CCDS93141.1
- UniProtKB/TrEMBL
- A0A7P0MUT5, A8JZZ5
- Related
- ENSP00000384835.2, ENST00000402731.6
- Conserved Domains (1) summary
-
- cd14084
Location:162 → 419
- STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2
-
NM_007194.4 → NP_009125.1 serine/threonine-protein kinase Chk2 isoform a
See identical proteins and their annotated locations for NP_009125.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform a.
- Source sequence(s)
-
AF096279, AW778747, BM838597
- Consensus CDS
-
CCDS13843.1
- UniProtKB/Swiss-Prot
- A8K3Y9, B7ZBF3, B7ZBF4, B7ZBF5, O96017, Q6QA03, Q6QA04, Q6QA05, Q6QA06, Q6QA07, Q6QA08, Q6QA10, Q6QA11, Q6QA12, Q6QA13, Q9HBS5, Q9HCQ8, Q9UGF0, Q9UGF1
- UniProtKB/TrEMBL
-
A8JZZ5
- Related
- ENSP00000385747.1, ENST00000404276.6
- Conserved Domains (2) summary
-
- cd00060
Location:93 → 201
- FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
- cd14084
Location:213 → 486
- STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2
-
NM_145862.2 → NP_665861.1 serine/threonine-protein kinase Chk2 isoform b
See identical proteins and their annotated locations for NP_665861.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
- Source sequence(s)
-
AW778747, AY551299, BM838597
- Consensus CDS
-
CCDS13844.1
- UniProtKB/TrEMBL
-
A8JZZ5
- Related
- ENSP00000329012.5, ENST00000348295.7
- Conserved Domains (4) summary
-
- smart00220
Location:220 → 457
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- COG1716
Location:116 → 199
- FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
- cd00060
Location:93 → 201
- FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
- cl21453
Location:213 → 457
- PKc_like; Protein Kinases, catalytic domain
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000022.11 Reference GRCh38.p14 Primary Assembly
- Range
-
28687743..28741834 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_011529845.3 → XP_011528147.1 serine/threonine-protein kinase Chk2 isoform X15
See identical proteins and their annotated locations for XP_011528147.1
- UniProtKB/TrEMBL
-
A0A087X102
- Related
- ENSP00000390244.2, ENST00000425190.7
- Conserved Domains (2) summary
-
- smart00220
Location:3 → 265
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- cd14084
Location:1 → 265
- STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2
-
XM_047441106.1 → XP_047297062.1 serine/threonine-protein kinase Chk2 isoform X7
- UniProtKB/TrEMBL
-
A8JZZ5
-
XM_047441104.1 → XP_047297060.1 serine/threonine-protein kinase Chk2 isoform X3
- UniProtKB/TrEMBL
-
A8JZZ5
-
XM_047441105.1 → XP_047297061.1 serine/threonine-protein kinase Chk2 isoform X5
- UniProtKB/TrEMBL
-
A8JZZ5
-
XM_011529839.3 → XP_011528141.1 serine/threonine-protein kinase Chk2 isoform X1
- UniProtKB/TrEMBL
-
A8JZZ5
- Conserved Domains (2) summary
-
- cd00060
Location:166 → 254
- FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
- cd14084
Location:266 → 539
- STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2
-
XM_024452149.2 → XP_024307917.1 serine/threonine-protein kinase Chk2 isoform X9
- UniProtKB/TrEMBL
-
A8JZZ5
- Conserved Domains (2) summary
-
- cd00060
Location:103 → 211
- FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
- cl21453
Location:223 → 467
- PKc_like; Protein Kinases, catalytic domain
-
XM_024452148.2 → XP_024307916.1 serine/threonine-protein kinase Chk2 isoform X6
- UniProtKB/TrEMBL
-
A8JZZ5
- Conserved Domains (2) summary
-
- cd00060
Location:103 → 211
- FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
- cd14084
Location:223 → 496
- STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2
-
XM_047441107.1 → XP_047297063.1 serine/threonine-protein kinase Chk2 isoform X8
- UniProtKB/TrEMBL
-
A8JZZ5
-
XM_011529840.4 → XP_011528142.1 serine/threonine-protein kinase Chk2 isoform X4
- UniProtKB/TrEMBL
-
A8JZZ5
- Conserved Domains (4) summary
-
- smart00220
Location:273 → 510
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- COG1716
Location:123 → 252
- FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
- cd00060
Location:166 → 254
- FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
- cl21453
Location:266 → 510
- PKc_like; Protein Kinases, catalytic domain
-
XM_011529842.3 → XP_011528144.1 serine/threonine-protein kinase Chk2 isoform X10
- UniProtKB/TrEMBL
-
A8JZZ5
- Conserved Domains (2) summary
-
- smart00220
Location:172 → 429
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- cd14084
Location:172 → 429
- STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2
-
XM_017028560.2 → XP_016884049.1 serine/threonine-protein kinase Chk2 isoform X2
- UniProtKB/TrEMBL
-
A8JZZ5
-
XM_047441108.1 → XP_047297064.1 serine/threonine-protein kinase Chk2 isoform X13
- UniProtKB/TrEMBL
-
A0A087X102
-
XM_006724114.4 → XP_006724177.3 serine/threonine-protein kinase Chk2 isoform X12
- UniProtKB/TrEMBL
-
A0A087X102
- Related
-
ENST00000648295.1
-
XM_006724116.3 → XP_006724179.2 serine/threonine-protein kinase Chk2 isoform X14
- UniProtKB/TrEMBL
-
A0A087X102
- Related
- ENSP00000483777.2, ENST00000464581.6
- Conserved Domains (2) summary
-
- smart00220
Location:46 → 305
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- cd14084
Location:39 → 305
- STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2
-
XM_011529844.3 → XP_011528146.1 serine/threonine-protein kinase Chk2 isoform X11
- UniProtKB/TrEMBL
-
A0AA34QVK6
- Related
- ENSP00000518557.1, ENST00000711048.1
- Conserved Domains (4) summary
-
- smart00220
Location:273 → 390
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- COG1716
Location:123 → 252
- FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
- cd00060
Location:166 → 254
- FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
- cl21453
Location:266 → 390
- PKc_like; Protein Kinases, catalytic domain
RNA
-
XR_937806.3 RNA Sequence
-
XR_007067955.1 RNA Sequence
-
XR_007067954.1 RNA Sequence
-
XR_937807.3 RNA Sequence
Alternate T2T-CHM13v2.0
Genomic
-
NC_060946.1 Alternate T2T-CHM13v2.0
- Range
-
29149178..29203469 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054325051.1 → XP_054181026.1 serine/threonine-protein kinase Chk2 isoform X15
- UniProtKB/TrEMBL
-
A0A087X102
-
XM_054325043.1 → XP_054181018.1 serine/threonine-protein kinase Chk2 isoform X7
- UniProtKB/TrEMBL
-
A8JZZ5
-
XM_054325039.1 → XP_054181014.1 serine/threonine-protein kinase Chk2 isoform X3
- UniProtKB/TrEMBL
-
A8JZZ5
-
XM_054325041.1 → XP_054181016.1 serine/threonine-protein kinase Chk2 isoform X5
- UniProtKB/TrEMBL
-
A8JZZ5
-
XM_054325037.1 → XP_054181012.1 serine/threonine-protein kinase Chk2 isoform X1
- UniProtKB/TrEMBL
-
A8JZZ5
-
XM_054325045.1 → XP_054181020.1 serine/threonine-protein kinase Chk2 isoform X9
- UniProtKB/TrEMBL
-
A8JZZ5
-
XM_054325042.1 → XP_054181017.1 serine/threonine-protein kinase Chk2 isoform X6
- UniProtKB/TrEMBL
-
A8JZZ5
-
XM_054325044.1 → XP_054181019.1 serine/threonine-protein kinase Chk2 isoform X8
- UniProtKB/TrEMBL
-
A8JZZ5
-
XM_054325040.1 → XP_054181015.1 serine/threonine-protein kinase Chk2 isoform X4
- UniProtKB/TrEMBL
-
A8JZZ5
-
XM_054325046.1 → XP_054181021.1 serine/threonine-protein kinase Chk2 isoform X10
- UniProtKB/TrEMBL
-
A8JZZ5
-
XM_054325038.1 → XP_054181013.1 serine/threonine-protein kinase Chk2 isoform X2
- UniProtKB/TrEMBL
-
A8JZZ5
-
XM_054325049.1 → XP_054181024.1 serine/threonine-protein kinase Chk2 isoform X17
-
XM_054325048.1 → XP_054181023.1 serine/threonine-protein kinase Chk2 isoform X16
-
XM_054325050.1 → XP_054181025.1 serine/threonine-protein kinase Chk2 isoform X14
- UniProtKB/TrEMBL
-
A0A087X102
-
XM_054325047.1 → XP_054181022.1 serine/threonine-protein kinase Chk2 isoform X11
- UniProtKB/TrEMBL
-
A0AA34QVK6
RNA
-
XR_008485362.1 RNA Sequence
-
XR_008485364.1 RNA Sequence
-
XR_008485361.1 RNA Sequence
-
XR_008485363.1 RNA Sequence