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    ZNF790 zinc finger protein 790 [ Homo sapiens (human) ]

    Gene ID: 388536, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ZNF790provided by HGNC
    Official Full Name
    zinc finger protein 790provided by HGNC
    Primary source
    HGNC:HGNC:33114
    See related
    Ensembl:ENSG00000197863 AllianceGenome:HGNC:33114
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 1.2), kidney (RPKM 1.1) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF790 in Genome Data Viewer
    Location:
    19q13.12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (36817428..36850792, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (39493114..39526474, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (37308330..37341694, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 850 Neighboring gene Sharpr-MPRA regulatory region 9870 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14533 Neighboring gene uncharacterized LOC728485 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:37282721-37283221 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10551 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10552 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14534 Neighboring gene ZNF790 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14535 Neighboring gene zinc finger protein 345 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:37368334-37369533 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:37382329-37383528 Neighboring gene zinc finger protein 829 Neighboring gene ribosomal protein L31 pseudogene 61 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14536 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14537 Neighboring gene zinc finger protein 568

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. Lee OH, et al. Mol Cell Proteomics, 2011 Feb. PMID 21044950, Free PMC Article
    2. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965, Free PMC Article
    3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20350, MGC62100

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 790

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242800.2 → NP_001229729.1  zinc finger protein 790

      See identical proteins and their annotated locations for NP_001229729.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents a distinct first exon and 5' UTR.
      Source sequence(s)
      AC008733, AC020928, AK297474, DC308617, EL735861
      Consensus CDS
      CCDS12496.1
      UniProtKB/Swiss-Prot
      Q6PG37
      Related
      ENSP00000480764.1, ENST00000613249.4
      Conserved Domains (3) summary
      smart00349
      Location:5 → 64
      KRAB; krueppel associated box
      COG5048
      Location:308 → 575
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:284 → 304
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001242801.2 → NP_001229730.1  zinc finger protein 790

      See identical proteins and their annotated locations for NP_001229730.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents a distinct first exon and 5' UTR.
      Source sequence(s)
      AC020928, AK297474, BF132049, DC307556, DC352882, DC377558
      Consensus CDS
      CCDS12496.1
      UniProtKB/Swiss-Prot
      Q6PG37
      Related
      ENSP00000480834.1, ENST00000614179.4
      Conserved Domains (3) summary
      smart00349
      Location:5 → 64
      KRAB; krueppel associated box
      COG5048
      Location:308 → 575
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:284 → 304
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001242802.2 → NP_001229731.1  zinc finger protein 790

      See identical proteins and their annotated locations for NP_001229731.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents a distinct first exon and 5' UTR.
      Source sequence(s)
      AC020928, AK297474, DC324605
      Consensus CDS
      CCDS12496.1
      UniProtKB/Swiss-Prot
      Q6PG37
      Related
      ENSP00000478852.1, ENST00000615484.4
      Conserved Domains (3) summary
      smart00349
      Location:5 → 64
      KRAB; krueppel associated box
      COG5048
      Location:308 → 575
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:284 → 304
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. NM_206894.4 → NP_996777.2  zinc finger protein 790

      See identical proteins and their annotated locations for NP_996777.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents a distinct first exon.
      Source sequence(s)
      AC020928, AK297474, BM473790
      Consensus CDS
      CCDS12496.1
      UniProtKB/Swiss-Prot
      Q6PG37
      Related
      ENSP00000349161.3, ENST00000356725.9
      Conserved Domains (3) summary
      smart00349
      Location:5 → 64
      KRAB; krueppel associated box
      COG5048
      Location:308 → 575
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:284 → 304
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      36817428..36850792 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438800.1 → XP_047294756.1  zinc finger protein 790 isoform X2

      UniProtKB/Swiss-Prot
      Q6PG37

    2. XM_005258903.6 → XP_005258960.1  zinc finger protein 790 isoform X2

      See identical proteins and their annotated locations for XP_005258960.1

      UniProtKB/Swiss-Prot
      Q6PG37
      Conserved Domains (3) summary
      smart00349
      Location:5 → 64
      KRAB; krueppel associated box
      COG5048
      Location:308 → 575
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:284 → 304
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_047438799.1 → XP_047294755.1  zinc finger protein 790 isoform X2

      UniProtKB/Swiss-Prot
      Q6PG37

    4. XM_011526950.4 → XP_011525252.1  zinc finger protein 790 isoform X2

      See identical proteins and their annotated locations for XP_011525252.1

      UniProtKB/Swiss-Prot
      Q6PG37
      Conserved Domains (3) summary
      smart00349
      Location:5 → 64
      KRAB; krueppel associated box
      COG5048
      Location:308 → 575
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:284 → 304
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. XM_047438801.1 → XP_047294757.1  zinc finger protein 790 isoform X2

      UniProtKB/Swiss-Prot
      Q6PG37

    6. XM_047438798.1 → XP_047294754.1  zinc finger protein 790 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      39493114..39526474 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320957.1 → XP_054176932.1  zinc finger protein 790 isoform X2

      UniProtKB/Swiss-Prot
      Q6PG37

    2. XM_054320955.1 → XP_054176930.1  zinc finger protein 790 isoform X2

      UniProtKB/Swiss-Prot
      Q6PG37

    3. XM_054320954.1 → XP_054176929.1  zinc finger protein 790 isoform X2

      UniProtKB/Swiss-Prot
      Q6PG37

    4. XM_054320956.1 → XP_054176931.1  zinc finger protein 790 isoform X2

      UniProtKB/Swiss-Prot
      Q6PG37

    5. XM_054320958.1 → XP_054176933.1  zinc finger protein 790 isoform X2

      UniProtKB/Swiss-Prot
      Q6PG37

    6. XM_054320953.1 → XP_054176928.1  zinc finger protein 790 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PG37.2 GenPept UniProtKB/Swiss-Prot:Q6PG37

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