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    PPP2R3C protein phosphatase 2 regulatory subunit B''gamma [ Homo sapiens (human) ]

    Gene ID: 55012, updated on 3-Dec-2024

    Summary

    Official Symbol
    PPP2R3Cprovided by HGNC
    Official Full Name
    protein phosphatase 2 regulatory subunit B''gammaprovided by HGNC
    Primary source
    HGNC:HGNC:17485
    See related
    Ensembl:ENSG00000092020 MIM:615902; AllianceGenome:HGNC:17485
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    G4-1; G5pr; GDRM; MEGD; SPGF36; C14orf10
    Summary
    This gene encodes a regulatory subunit of the serine/threonine phosphatase, protein phosphatase 2. This protein is localized to both nuclear and cytoplasmic regions depending on cell cycle phase. Homozygous conditional knockout mice for this gene exhibit reduced numbers and impaired proliferation of immune system B cells. This protein may regulate the expression of the P-glycoprotein ATP-binding cassette transporter through its phosphatase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
    Expression
    Broad expression in testis (RPKM 18.2), bone marrow (RPKM 7.6) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See PPP2R3C in Genome Data Viewer
    Location:
    14q13.2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (35085472..35122298, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (29282404..29319252, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (35554678..35591504, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:35451517-35452218 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8259 Neighboring gene signal recognition particle 54 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8260 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5673 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8261 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8262 Neighboring gene family with sequence similarity 177 member A1 Neighboring gene uncharacterized LOC101927178 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:35571935-35572102 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr14:35581755-35582536 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:35590400-35591599 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:35591739-35592658 Neighboring gene PRORP-PSMA6 readthrough Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:35622091-35622592 Neighboring gene protein only RNase P catalytic subunit Neighboring gene ribosomal protein L23a pseudogene 70 Neighboring gene septin 7 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ20644

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in B cell homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in T cell homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cortical cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of B cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of antimicrobial humoral response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of mitochondrial depolarization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spleen development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma
    Names
    protein phosphatase 2 (formerly 2A), regulatory subunit B''
    protein phosphatase 2, regulatory subunit B'', gamma
    protein phosphatase subunit G5PR
    rhabdomyosarcoma antigen MU-RMS-40.6A
    rhabdomyosarcoma antigen Mu-RMS-40.6C

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305155.2NP_001292084.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform 2

      See identical proteins and their annotated locations for NP_001292084.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in its 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Both variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AA603611, AY157304, BC063438
      UniProtKB/Swiss-Prot
      Q969Q6
      Conserved Domains (1) summary
      cd21505
      Location:3327
      PPP2R3C; serine/threonine protein phosphatase 2A regulatory subunit B" subunit gamma
    2. NM_001305156.2NP_001292085.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform 2

      See identical proteins and their annotated locations for NP_001292085.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' terminal exon and lacks an alternate internal exon in its 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Both variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AA603611, AK293717
      UniProtKB/Swiss-Prot
      Q969Q6
      Conserved Domains (1) summary
      cd21505
      Location:3327
      PPP2R3C; serine/threonine protein phosphatase 2A regulatory subunit B" subunit gamma
    3. NM_017917.4NP_060387.2  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform 1

      See identical proteins and their annotated locations for NP_060387.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AY157304
      Consensus CDS
      CCDS9654.1
      UniProtKB/Swiss-Prot
      B4DEN7, D3DS97, D3DS98, Q5GJ55, Q5GJ56, Q6P4G2, Q86TZ3, Q969Q6, Q9NWR9
      Related
      ENSP00000261475.5, ENST00000261475.10
      Conserved Domains (1) summary
      pfam17958
      Location:184258
      EF-hand_13; EF-hand domain

    RNA

    1. NR_130972.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains an alternate 5' terminal exon and lacks two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BC100021, BX248043
      Related
      ENST00000553273.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      35085472..35122298 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005267782.5XP_005267839.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1

      See identical proteins and their annotated locations for XP_005267839.1

      UniProtKB/Swiss-Prot
      B4DEN7, D3DS97, D3DS98, Q5GJ55, Q5GJ56, Q6P4G2, Q86TZ3, Q969Q6, Q9NWR9
      Conserved Domains (1) summary
      pfam17958
      Location:184258
      EF-hand_13; EF-hand domain
    2. XM_024449638.2XP_024305406.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X2

      Conserved Domains (1) summary
      cd21505
      Location:25406
      PPP2R3C; serine/threonine protein phosphatase 2A regulatory subunit B" subunit gamma
    3. XM_024449639.2XP_024305407.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X3

    4. XM_047431517.1XP_047287473.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X4

      UniProtKB/TrEMBL
      G3V2K1
      Related
      ENSP00000450716.1, ENST00000554361.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      29282404..29319252 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054376276.1XP_054232251.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1

      UniProtKB/Swiss-Prot
      B4DEN7, D3DS97, D3DS98, Q5GJ55, Q5GJ56, Q6P4G2, Q86TZ3, Q969Q6, Q9NWR9
    2. XM_054376277.1XP_054232252.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X2

    3. XM_054376278.1XP_054232253.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X3

    4. XM_054376279.1XP_054232254.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X4

      UniProtKB/TrEMBL
      G3V2K1