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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
mRNA and Protein(s)
-
NM_001098531.4 → NP_001092001.2 rap guanine nucleotide exchange factor 3 isoform a
Status: VALIDATED
- Description
- Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
- Source sequence(s)
-
AC004241
- Consensus CDS
-
CCDS41775.1
- UniProtKB/Swiss-Prot
- A8K2G5, E7EQC8, O95398, O95634, Q8WVN0
- UniProtKB/TrEMBL
-
Q569L6
- Related
- ENSP00000395708.2, ENST00000449771.7
- Conserved Domains (4) summary
-
- cd06224
Location:392 → 511
- REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
- cd00038
Location:247 → 356
- CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
- cd00155
Location:658 → 890
- RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
- cd04437
Location:100 → 223
- DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
-
NM_001098532.2 → NP_001092002.1 rap guanine nucleotide exchange factor 3 isoform b
See identical proteins and their annotated locations for NP_001092002.1
Status: VALIDATED
- Description
- Transcript Variant: This variant (3) contains an alternate 5' end and differs in the 5' UTR, compared to variant 1. These differences cause translation initiation at a downstream AUG and an isoform (b) with a shorter N-terminus compared to isoform a. Variants 2 and 3 encode the same isoform.
- Source sequence(s)
-
AC004241, AK092448, BQ007070, CN294139, DB179165, DB278856, U79275
- Consensus CDS
-
CCDS31784.1
- UniProtKB/TrEMBL
-
Q569L6
- Conserved Domains (5) summary
-
- cd06224
Location:350 → 469
- REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
- COG0664
Location:226 → 304
- Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
- cd00038
Location:205 → 314
- CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
- cd00155
Location:616 → 848
- RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
- cd04437
Location:58 → 181
- DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
-
NM_006105.5 → NP_006096.2 rap guanine nucleotide exchange factor 3 isoform b
See identical proteins and their annotated locations for NP_006096.2
Status: VALIDATED
- Description
- Transcript Variant: This variant (2) contains an alternate 5' exon and differs in the 5' UTR, compared to variant 1. These differences cause translation initiation at a downstream AUG and an isoform (b) with a shorter N-terminus compared to isoform a. Variants 2 and 3 encode the same isoform.
- Source sequence(s)
-
AC004241, AK092448, BQ007070, CN294139, DA629958, U79275
- Consensus CDS
-
CCDS31784.1
- UniProtKB/TrEMBL
-
Q569L6
- Related
- ENSP00000384521.2, ENST00000405493.6
- Conserved Domains (5) summary
-
- cd06224
Location:350 → 469
- REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
- COG0664
Location:226 → 304
- Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
- cd00038
Location:205 → 314
- CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
- cd00155
Location:616 → 848
- RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
- cd04437
Location:58 → 181
- DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000012.12 Reference GRCh38.p14 Primary Assembly
- Range
-
47734363..47758880 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_011537752.3 → XP_011536054.1 rap guanine nucleotide exchange factor 3 isoform X1
- UniProtKB/TrEMBL
-
Q569L6
- Conserved Domains (5) summary
-
- cd06224
Location:407 → 526
- REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
- COG0664
Location:283 → 361
- Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
- cd00038
Location:262 → 371
- CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
- cd00155
Location:673 → 905
- RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
- cd04437
Location:100 → 238
- DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
-
XM_011537755.2 → XP_011536057.1 rap guanine nucleotide exchange factor 3 isoform X2
- UniProtKB/TrEMBL
-
Q569L6
- Conserved Domains (5) summary
-
- cd06224
Location:365 → 484
- REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
- COG0664
Location:241 → 319
- Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
- cd00038
Location:220 → 329
- CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
- cd00155
Location:631 → 863
- RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
- cd04437
Location:58 → 196
- DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
-
XM_011537758.3 → XP_011536060.1 rap guanine nucleotide exchange factor 3 isoform X4
- UniProtKB/TrEMBL
-
Q569L6
- Conserved Domains (5) summary
-
- cd06224
Location:248 → 367
- REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
- COG0664
Location:124 → 202
- Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
- cd00038
Location:103 → 212
- CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
- cd00155
Location:514 → 746
- RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
- cl02442
Location:32 → 79
- DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...
-
XM_005268571.4 → XP_005268628.1 rap guanine nucleotide exchange factor 3 isoform X6
- UniProtKB/TrEMBL
-
B3KWQ0
- Conserved Domains (2) summary
-
- cd06224
Location:1 → 83
- REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
- cd00155
Location:230 → 462
- RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
-
XM_047428081.1 → XP_047284037.1 rap guanine nucleotide exchange factor 3 isoform X3
- UniProtKB/TrEMBL
-
Q569L6
-
XM_017018688.3 → XP_016874177.1 rap guanine nucleotide exchange factor 3 isoform X5
- Related
- ENSP00000378764.3, ENST00000395358.7
RNA
-
XR_001748551.3 RNA Sequence
Alternate T2T-CHM13v2.0
Genomic
-
NC_060936.1 Alternate T2T-CHM13v2.0
- Range
-
47695675..47720196 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054370767.1 → XP_054226742.1 rap guanine nucleotide exchange factor 3 isoform X1
- UniProtKB/TrEMBL
-
Q569L6
-
XM_054370768.1 → XP_054226743.1 rap guanine nucleotide exchange factor 3 isoform X2
- UniProtKB/TrEMBL
-
Q569L6
-
XM_054370770.1 → XP_054226745.1 rap guanine nucleotide exchange factor 3 isoform X4
- UniProtKB/TrEMBL
-
Q569L6
-
XM_054370772.1 → XP_054226747.1 rap guanine nucleotide exchange factor 3 isoform X6
- UniProtKB/TrEMBL
-
B3KWQ0
-
XM_054370769.1 → XP_054226744.1 rap guanine nucleotide exchange factor 3 isoform X3
- UniProtKB/TrEMBL
-
Q569L6
-
XM_054370771.1 → XP_054226746.1 rap guanine nucleotide exchange factor 3 isoform X5
RNA
-
XR_008488507.1 RNA Sequence