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    KAT5 lysine acetyltransferase 5 [ Homo sapiens (human) ]

    Gene ID: 10524, updated on 3-Dec-2024

    Summary

    Official Symbol
    KAT5provided by HGNC
    Official Full Name
    lysine acetyltransferase 5provided by HGNC
    Primary source
    HGNC:HGNC:5275
    See related
    Ensembl:ENSG00000172977 MIM:601409; AllianceGenome:HGNC:5275
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TIP; ESA1; PLIP; TIP60; cPLA2; HTATIP; ZC2HC5; HTATIP1; NEDFASB
    Summary
    The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 21.5), thyroid (RPKM 20.0) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See KAT5 in Genome Data Viewer
    Location:
    11q13.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (65712018..65719604)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (65706411..65713762)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (65479723..65487075)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3550 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5000 Neighboring gene RELA proto-oncogene, NF-kB subunit Neighboring gene RELA divergent transcript Neighboring gene RNA, 7SL, cytoplasmic 309, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5001 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5002 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3551 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3552 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3553 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5003 Neighboring gene ribonuclease H2 subunit C Neighboring gene keratin 8 pseudogene 26 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:65544816-65545720 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:65547529-65548431 Neighboring gene adaptor related protein complex 5 subunit beta 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Neurodevelopmental disorder with dysmorphic facies, sleep disturbance, and brain abnormalities
    MedGen: C5436821 OMIM: 619103 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Discovery and refinement of loci associated with lipid levels.
    EBI GWAS Catalog
    Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
    EBI GWAS Catalog
    New loci associated with kidney function and chronic kidney disease.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Reduced levels of Tip60 by HIV-1 Tat is sufficient to restore the effectiveness of antiviral drug maribivar to inhibit beta-herpes virus human cytomegalovirus PubMed
    tat HIV-1 Tat forms a quaternary complex with Tip60, Plk1, and cyclin B1 to inhibit Plk1-mediated phosphorylation of cyclin B1 at Ser133 position PubMed
    tat HIV-1 Tat induces the polyubiquitination and degradation of Tip60 through p300/CBP-associated E4-type ubiquitin-ligase activity, which results in a dramatic impairment of the Tip60-dependent apoptotic cell response to DNA damage PubMed
    tat Tip60 inhibits HIV-1 Tat activation of the HIV-1 LTR promoter in Jurkat cells PubMed
    tat Tip60 enhances HIV-1 Tat activation of the HIV-1 LTR promoter in HeLa cells PubMed
    tat HIV-1 Tat inhibits Tip60 histone-acetyltransferase activity and abolishes Tip60-dependent transcriptional activity of the Mn-SOD promoter PubMed
    tat Tip60 is a nuclear histone acetyltransferase that binds to the N-terminal 31 amino acids of HIV-1 Tat PubMed
    matrix gag HIV-1 MA downregulates KAT5 gene expression in HepG2 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables acetyltransferase activity TAS
    Traceable Author Statement
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone H2A acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone H2AK5 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone H2AK9 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BK12 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BK5 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K122 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K14 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K18 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K23 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K27 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K36 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K4 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K56 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K9 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone H4K12 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4K16 acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histone H4K16 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone H4K5 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4K8 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone acetyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables histone crotonyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone lactyltransferase (CoA-dependent) activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptide 2-hydroxyisobutyryltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptide butyryltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptide crotonyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptide lactyltransferase (CoA-dependent) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptide-lysine-N-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription coactivator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in DNA repair-dependent chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in DNA repair-dependent chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to estradiol stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to glucose starvation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular senescence TAS
    Traceable Author Statement
    more info
     
    involved_in double-strand break repair IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in double-strand break repair TAS
    Traceable Author Statement
    more info
     
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in double-strand break repair via homologous recombination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in establishment of mitotic spindle orientation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_positive_effect lipid droplet disassembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of double-strand break repair via homologous recombination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of interleukin-2 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neural tube development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neurogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nucleotide-excision repair IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-lysine acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of aggrephagy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of attachment of mitotic spindle microtubules to kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of autophagy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of circadian rhythm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of double-strand break repair via homologous recombination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of innate immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of mitotic sister chromatid segregation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of myoblast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of regulatory T cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of triglyceride biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of apoptotic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of double-strand break repair NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of hematopoietic stem cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to ionizing radiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in sperm DNA condensation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spermatid development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of NuA4 histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of Swr1 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitotic spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    part_of nucleosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    part_of piccolo histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in site of double-strand break IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    histone acetyltransferase KAT5
    Names
    60 kDa Tat-interactive protein
    HIV-1 Tat interactive protein, 60kDa
    K(lysine) acetyltransferase 5
    K-acetyltransferase 5
    Tat interacting protein, 60kDa
    cPLA(2)-interacting protein
    cPLA2 interacting protein
    histone acetyltransferase HTATIP
    protein 2-hydroxyisobutyryltransferase KAT5
    protein acetyltransferase KAT5
    protein crotonyltransferase KAT5
    NP_001193762.1
    NP_006379.2
    NP_874368.1
    NP_874369.1
    XP_006718484.1
    XP_047282208.1
    XP_047282209.1
    XP_054223442.1
    XP_054223443.1
    XP_054223444.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033057.1 RefSeqGene

      Range
      5251..12603
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001206833.2NP_001193762.1  histone acetyltransferase KAT5 isoform 4

      See identical proteins and their annotated locations for NP_001193762.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting protein (isoform 4) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AK304664, BC013211, BU737532
      Consensus CDS
      CCDS55771.1
      UniProtKB/TrEMBL
      Q59EJ8
      Related
      ENSP00000434765.1, ENST00000530446.5
      Conserved Domains (2) summary
      PLN00104
      Location:76485
      PLN00104; MYST -like histone acetyltransferase; Provisional
      pfam11717
      Location:4098
      Tudor-knot; RNA binding activity-knot of a chromodomain
    2. NM_006388.4NP_006379.2  histone acetyltransferase KAT5 isoform 2

      See identical proteins and their annotated locations for NP_006379.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), also known as alpha, lacks an alternate in-frame segment, compared to variant 1, resulting in a shorter protein (isoform 2), that has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      BC064912, BU737532, DA043042
      Consensus CDS
      CCDS31610.1
      UniProtKB/Swiss-Prot
      B4E3C7, C9JL99, O95624, Q13430, Q17RW5, Q561W3, Q6GSE8, Q92993, Q9BWK7
      UniProtKB/TrEMBL
      B2R8A7
      Related
      ENSP00000366245.3, ENST00000377046.7
      Conserved Domains (2) summary
      PLN00104
      Location:43504
      PLN00104; MYST -like histone acetyltransferase; Provisional
      pfam11717
      Location:765
      Tudor-knot; RNA binding activity-knot of a chromodomain
    3. NM_182709.3NP_874368.1  histone acetyltransferase KAT5 isoform 3

      See identical proteins and their annotated locations for NP_874368.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), also known as beta, lacks two alternate in-frame segments, compared to variant 1, resulting in a shorter protein (isoform 3), that has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      BC000166, BU737532, DB003934
      Consensus CDS
      CCDS8109.1
      UniProtKB/TrEMBL
      Q59EJ8
      Related
      ENSP00000344955.4, ENST00000352980.8
      Conserved Domains (2) summary
      PLN00104
      Location:43452
      PLN00104; MYST -like histone acetyltransferase; Provisional
      pfam11717
      Location:765
      Tudor-knot; RNA binding activity-knot of a chromodomain
    4. NM_182710.3NP_874369.1  histone acetyltransferase KAT5 isoform 1

      See identical proteins and their annotated locations for NP_874369.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
      Source sequence(s)
      BC013211, BU737532, DB103287
      Consensus CDS
      CCDS8110.1
      UniProtKB/TrEMBL
      B2R8A7
      Related
      ENSP00000340330.4, ENST00000341318.9
      Conserved Domains (2) summary
      PLN00104
      Location:76537
      PLN00104; MYST -like histone acetyltransferase; Provisional
      pfam11717
      Location:4098
      Tudor-knot; RNA binding activity-knot of a chromodomain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      65712018..65719604
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426253.1XP_047282209.1  histone acetyltransferase KAT5 isoform X3

    2. XM_006718421.4XP_006718484.1  histone acetyltransferase KAT5 isoform X1

      See identical proteins and their annotated locations for XP_006718484.1

      UniProtKB/TrEMBL
      B2R8A7
      Conserved Domains (2) summary
      PLN00104
      Location:43513
      PLN00104; MYST -like histone acetyltransferase; Provisional
      pfam11717
      Location:765
      Tudor-knot; RNA binding activity-knot of a chromodomain
    3. XM_047426252.1XP_047282208.1  histone acetyltransferase KAT5 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      65706411..65713762
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367467.1XP_054223442.1  histone acetyltransferase KAT5 isoform X1

      UniProtKB/TrEMBL
      B2R8A7
    2. XM_054367468.1XP_054223443.1  histone acetyltransferase KAT5 isoform X2

    3. XM_054367469.1XP_054223444.1  histone acetyltransferase KAT5 isoform X3