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    ZRANB2 zinc finger RANBP2-type containing 2 [ Homo sapiens (human) ]

    Gene ID: 9406, updated on 9-Dec-2024

    Summary

    Official Symbol
    ZRANB2provided by HGNC
    Official Full Name
    zinc finger RANBP2-type containing 2provided by HGNC
    Primary source
    HGNC:HGNC:13058
    See related
    Ensembl:ENSG00000132485 MIM:604347; AllianceGenome:HGNC:13058
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZIS; ZIS1; ZIS2; ZNF265
    Summary
    Enables RNA binding activity. Predicted to be involved in RNA splicing and mRNA processing. Located in nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in endometrium (RPKM 47.3), lymph node (RPKM 37.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZRANB2 in Genome Data Viewer
    Location:
    1p31.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (71063291..71081035, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (70941292..70959042, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (71528974..71546718, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:71172243-71172742 Neighboring gene MPRA-validated peak284 silencer Neighboring gene long intergenic non-protein coding RNA 1788 Neighboring gene uncharacterized LOC102724572 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:71429249-71429748 Neighboring gene prostaglandin E receptor 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:71512913-71513496 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 991 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1198 Neighboring gene ZRANB2 antisense RNA 1 Neighboring gene uncharacterized LOC105378795 Neighboring gene ZRANB2 divergent transcript Neighboring gene microRNA 186 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:71927989-71928559 Neighboring gene neuronal growth regulator 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:72203394-72203980 Neighboring gene NEGR1 intronic transcript 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ41119, DKFZp686J1831, DKFZp686N09117

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables lipopolysaccharide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    zinc finger Ran-binding domain-containing protein 2
    Names
    zinc finger protein 265
    zinc finger, RAN-binding domain containing 2
    zinc-finger, splicing

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005455.5NP_005446.2  zinc finger Ran-binding domain-containing protein 2 isoform 2

      See identical proteins and their annotated locations for NP_005446.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 3' coding region, which results in an early stop codon, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct N-terminus when it is compared to isoform 1.
      Source sequence(s)
      AL136945, AL512443, BC039814, BU677906, DA523601
      Consensus CDS
      CCDS660.1
      UniProtKB/Swiss-Prot
      O95218
      Related
      ENSP00000254821.6, ENST00000254821.10
      Conserved Domains (2) summary
      smart00547
      Location:6791
      ZnF_RBZ; Zinc finger domain
      sd00029
      Location:1334
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
    2. NM_203350.3NP_976225.1  zinc finger Ran-binding domain-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_976225.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
      Source sequence(s)
      AF065391, AL512443, BC033648, BU677906, DA523601
      Consensus CDS
      CCDS659.1
      UniProtKB/Swiss-Prot
      D3DQ75, O95218, Q53GS3, Q59F92, Q5VV33, Q5VV34, Q8IXN6, Q9UP63
      Related
      ENSP00000359958.3, ENST00000370920.8
      Conserved Domains (2) summary
      smart00547
      Location:6791
      ZnF_RBZ; Zinc finger domain
      sd00029
      Location:1334
      zf-RanBP2; RanBP2-type Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      71063291..71081035 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434733.1XP_047290689.1  zinc finger Ran-binding domain-containing protein 2 isoform X1

      Related
      ENSP00000482026.1, ENST00000611683.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      70941292..70959042 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339678.1XP_054195653.1  zinc finger Ran-binding domain-containing protein 2 isoform X1