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    THRAP3 thyroid hormone receptor associated protein 3 [ Homo sapiens (human) ]

    Gene ID: 9967, updated on 3-Dec-2024

    Summary

    Official Symbol
    THRAP3provided by HGNC
    Official Full Name
    thyroid hormone receptor associated protein 3provided by HGNC
    Primary source
    HGNC:HGNC:22964
    See related
    Ensembl:ENSG00000054118 MIM:603809; AllianceGenome:HGNC:22964
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BCLAF2; TRAP150
    Summary
    Enables nuclear thyroid hormone receptor binding activity; phosphoprotein binding activity; and transcription coactivator activity. Involved in positive regulation of circadian rhythm and regulation of gene expression. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in exon-exon junction complex and nuclear speck. Part of mediator complex. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in lymph node (RPKM 27.3), thyroid (RPKM 26.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See THRAP3 in Genome Data Viewer
    Location:
    1p34.3
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (36207637..36305357)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (36070513..36168203)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (36690044..36770958)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 655 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 656 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36625977-36626754 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 745 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 746 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:36638149-36639348 Neighboring gene MAP7 domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 657 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:36643121-36643768 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:36643769-36644414 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36644415-36645060 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36653458-36654156 Neighboring gene RNA, 7SL, cytoplasmic 131, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr1:36680691-36680811 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 747 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:36689434-36689961 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:36689962-36690490 Neighboring gene Sharpr-MPRA regulatory regions 10257 and 14041 Neighboring gene ubiquitin conjugating enzyme E2 V2 pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 659 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:36726300-36726456 Neighboring gene Sharpr-MPRA regulatory region 2392 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 660 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36772217-36773017 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36786744-36787628 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36788515-36789399 Neighboring gene SH3 domain containing 21 Neighboring gene eva-1 homolog B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 751 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:36823274-36823774 Neighboring gene serine/threonine kinase 40 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36834695-36835363 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36835364-36836031 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36837681-36838244 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36838245-36838808 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:36839045-36840244 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:36844393-36844892 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 666 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 667 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 668

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag HIV-1 Gag is identified to have a physical interaction with thyroid hormone receptor associated protein 3 (THRAP3) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    integrase gag-pol Using acetylated HIV-1 IN as bait in yeast two-hybrid screening identifies transcription regulatory and chromatin remodeling factors LEDGF/p75, KAP1, BTF3b, THRAP3, and HMGN2 as IN-binding partners PubMed
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human thyroid hormone receptor associated protein 3 (THRAP3) at amino acid residues 473-474 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ22082, MGC133082, MGC133083

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA binding HDA PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables nuclear receptor coactivator activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables nuclear thyroid hormone receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nuclear vitamin D receptor binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables phosphoprotein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription coregulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of exon-exon junction complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular exosome HDA PubMed 
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of mediator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    thyroid hormone receptor-associated protein 3
    Names
    BCLAF1 and THRAP3 family member 2
    TR-associated protein, 150-kDa
    thyroid hormone receptor-associated protein complex 150 kDa component
    thyroid hormone receptor-associated protein, 150 kDa subunit

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001321471.2NP_001308400.1  thyroid hormone receptor-associated protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC114484, AI754117, AK025735, BC112350, HY001123
      Consensus CDS
      CCDS405.1
      UniProtKB/Swiss-Prot
      D3DPS5, Q5VTK6, Q9Y2W1
      UniProtKB/TrEMBL
      A0A3B3ITZ9
      Related
      ENSP00000433825.1, ENST00000469141.6
      Conserved Domains (1) summary
      pfam15440
      Location:191769
      THRAP3_BCLAF1; THRAP3/BCLAF1 family
    2. NM_001321473.2NP_001308402.1  thyroid hormone receptor-associated protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AI754117, AK025735, BC112330, HY001123
      UniProtKB/TrEMBL
      A0A3B3ITZ9
      Conserved Domains (1) summary
      pfam15440
      Location:191769
      THRAP3_BCLAF1; THRAP3/BCLAF1 family
    3. NM_005119.4NP_005110.2  thyroid hormone receptor-associated protein 3 isoform 1

      See identical proteins and their annotated locations for NP_005110.2

      Status: VALIDATED

      Source sequence(s)
      AI754117, AK025735, BC112350, BG572651
      Consensus CDS
      CCDS405.1
      UniProtKB/Swiss-Prot
      D3DPS5, Q5VTK6, Q9Y2W1
      UniProtKB/TrEMBL
      A0A3B3ITZ9
      Related
      ENSP00000346634.5, ENST00000354618.10
      Conserved Domains (1) summary
      pfam15440
      Location:191769
      THRAP3_BCLAF1; THRAP3/BCLAF1 family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      36207637..36305357
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047436227.1XP_047292183.1  thyroid hormone receptor-associated protein 3 isoform X1

      UniProtKB/Swiss-Prot
      D3DPS5, Q5VTK6, Q9Y2W1
      UniProtKB/TrEMBL
      A0A3B3ITZ9
    2. XM_047436226.1XP_047292182.1  thyroid hormone receptor-associated protein 3 isoform X1

      UniProtKB/Swiss-Prot
      D3DPS5, Q5VTK6, Q9Y2W1
      UniProtKB/TrEMBL
      A0A3B3ITZ9
    3. XM_047436246.1XP_047292202.1  thyroid hormone receptor-associated protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A3B3ITZ9
    4. XM_047436215.1XP_047292171.1  thyroid hormone receptor-associated protein 3 isoform X1

      UniProtKB/Swiss-Prot
      D3DPS5, Q5VTK6, Q9Y2W1
      UniProtKB/TrEMBL
      A0A3B3ITZ9
    5. XM_047436245.1XP_047292201.1  thyroid hormone receptor-associated protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A3B3ITZ9
    6. XM_047436212.1XP_047292168.1  thyroid hormone receptor-associated protein 3 isoform X1

      UniProtKB/Swiss-Prot
      D3DPS5, Q5VTK6, Q9Y2W1
      UniProtKB/TrEMBL
      A0A3B3ITZ9
      Related
      ENSP00000498001.1, ENST00000648638.1
    7. XM_047436243.1XP_047292199.1  thyroid hormone receptor-associated protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A3B3ITZ9
    8. XM_047436222.1XP_047292178.1  thyroid hormone receptor-associated protein 3 isoform X1

      UniProtKB/Swiss-Prot
      D3DPS5, Q5VTK6, Q9Y2W1
      UniProtKB/TrEMBL
      A0A3B3ITZ9
    9. XM_047436252.1XP_047292208.1  thyroid hormone receptor-associated protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A3B3ITZ9
    10. XM_047436233.1XP_047292189.1  thyroid hormone receptor-associated protein 3 isoform X1

      UniProtKB/Swiss-Prot
      D3DPS5, Q5VTK6, Q9Y2W1
      UniProtKB/TrEMBL
      A0A3B3ITZ9
    11. XM_047436218.1XP_047292174.1  thyroid hormone receptor-associated protein 3 isoform X1

      UniProtKB/Swiss-Prot
      D3DPS5, Q5VTK6, Q9Y2W1
      UniProtKB/TrEMBL
      A0A3B3ITZ9
    12. XM_047436250.1XP_047292206.1  thyroid hormone receptor-associated protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A3B3ITZ9
    13. XM_047436232.1XP_047292188.1  thyroid hormone receptor-associated protein 3 isoform X1

      UniProtKB/Swiss-Prot
      D3DPS5, Q5VTK6, Q9Y2W1
      UniProtKB/TrEMBL
      A0A3B3ITZ9
    14. XM_047436254.1XP_047292210.1  thyroid hormone receptor-associated protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A3B3ITZ9
    15. XM_047436271.1XP_047292227.1  thyroid hormone receptor-associated protein 3 isoform X3

    RNA

    1. XR_007065302.1 RNA Sequence

    2. XR_007065301.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      36070513..36168203
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339973.1XP_054195948.1  thyroid hormone receptor-associated protein 3 isoform X1

      UniProtKB/Swiss-Prot
      D3DPS5, Q5VTK6, Q9Y2W1
      UniProtKB/TrEMBL
      A0A3B3ITZ9
    2. XM_054339972.1XP_054195947.1  thyroid hormone receptor-associated protein 3 isoform X1

      UniProtKB/Swiss-Prot
      D3DPS5, Q5VTK6, Q9Y2W1
      UniProtKB/TrEMBL
      A0A3B3ITZ9
    3. XM_054339978.1XP_054195953.1  thyroid hormone receptor-associated protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A3B3ITZ9
    4. XM_054339969.1XP_054195944.1  thyroid hormone receptor-associated protein 3 isoform X1

      UniProtKB/Swiss-Prot
      D3DPS5, Q5VTK6, Q9Y2W1
      UniProtKB/TrEMBL
      A0A3B3ITZ9
    5. XM_054339977.1XP_054195952.1  thyroid hormone receptor-associated protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A3B3ITZ9
    6. XM_054339968.1XP_054195943.1  thyroid hormone receptor-associated protein 3 isoform X1

      UniProtKB/Swiss-Prot
      D3DPS5, Q5VTK6, Q9Y2W1
      UniProtKB/TrEMBL
      A0A3B3ITZ9
    7. XM_054339976.1XP_054195951.1  thyroid hormone receptor-associated protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A3B3ITZ9
    8. XM_054339971.1XP_054195946.1  thyroid hormone receptor-associated protein 3 isoform X1

      UniProtKB/Swiss-Prot
      D3DPS5, Q5VTK6, Q9Y2W1
      UniProtKB/TrEMBL
      A0A3B3ITZ9
    9. XM_054339980.1XP_054195955.1  thyroid hormone receptor-associated protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A3B3ITZ9
    10. XM_054339975.1XP_054195950.1  thyroid hormone receptor-associated protein 3 isoform X1

      UniProtKB/Swiss-Prot
      D3DPS5, Q5VTK6, Q9Y2W1
      UniProtKB/TrEMBL
      A0A3B3ITZ9
    11. XM_054339970.1XP_054195945.1  thyroid hormone receptor-associated protein 3 isoform X1

      UniProtKB/Swiss-Prot
      D3DPS5, Q5VTK6, Q9Y2W1
      UniProtKB/TrEMBL
      A0A3B3ITZ9
    12. XM_054339979.1XP_054195954.1  thyroid hormone receptor-associated protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A3B3ITZ9
    13. XM_054339974.1XP_054195949.1  thyroid hormone receptor-associated protein 3 isoform X1

      UniProtKB/Swiss-Prot
      D3DPS5, Q5VTK6, Q9Y2W1
      UniProtKB/TrEMBL
      A0A3B3ITZ9
    14. XM_054339981.1XP_054195956.1  thyroid hormone receptor-associated protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A3B3ITZ9
    15. XM_054339982.1XP_054195957.1  thyroid hormone receptor-associated protein 3 isoform X3

    RNA

    1. XR_008486223.1 RNA Sequence

    2. XR_008486222.1 RNA Sequence