Dr1 down-regulator of transcription 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Dr1provided by RGD
Full Name: down-regulator of transcription 1provided by RGD
Primary source: RGD:1305201
See related: EnsemblRapid:ENSRNOG00000000070 AllianceGenome:RGD:1305201
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable RNA polymerase II general transcription initiation factor activity and TBP-class protein binding activity. Predicted to be involved in several processes, including RNA polymerase II preinitiation complex assembly; negative regulation of transcription by RNA polymerase II; and regulation of tubulin deacetylation. Predicted to be located in nucleoplasm. Predicted to be part of ATAC complex; RNA polymerase II transcription regulator complex; and negative cofactor 2 complex. Orthologous to human DR1 (down-regulator of transcription 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 198.9), Thymus (RPKM 155.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p22

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (1603203..1614556, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (1458223..1469578, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (2463651..2475004, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DR1-CSE/H2S pathway upregulates autophagy and inhibits H9C2 cells damage induced by high glucose.
Title: DR1-CSE/H(2)S pathway upregulates autophagy and inhibits H9C2 cells damage induced by high glucose.

Submit: New GeneRIF Correction

General gene information

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Markers

RH131134 (e-PCR)
- UniSTS:214417

AI179296 (e-PCR)
- UniSTS:250529

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II general transcription initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II general transcription initiation factor activity	ISO Inferred from Sequence Orthology more info
enables TBP-class protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables TBP-class protein binding	ISO Inferred from Sequence Orthology more info
enables general transcription initiation factor activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in RNA polymerase II preinitiation complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in biological_process	ND No biological Data available more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell division	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell division	ISO Inferred from Sequence Orthology more info
involved_in regulation of embryonic development	IEA Inferred from Electronic Annotation more info
involved_in regulation of embryonic development	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of tubulin deacetylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of ATAC complex	IEA Inferred from Electronic Annotation more info
part_of ATAC complex	ISO Inferred from Sequence Orthology more info
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
part_of negative cofactor 2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of negative cofactor 2 complex	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein Dr1

Names: NC2-beta; TATA-binding protein-associated phosphoprotein; down-regulator of transcription 1, TBP-binding (negative cofactor 2); negative cofactor 2-beta; protein Dr1-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001011914.1 → NP_001011914.1 protein Dr1

See identical proteins and their annotated locations for NP_001011914.1

Status: PROVISIONAL

Source sequence(s)

BC083822

UniProtKB/Swiss-Prot

Q5XI68

UniProtKB/TrEMBL

A6KPG5

Related

ENSRNOP00000000080.6, ENSRNOT00000000080.7

Conserved Domains (1) summary

cl23735
Location:7 → 130

H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...