Csf3r colony stimulating factor 3 receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Csf3rprovided by RGD
Official Full Name: colony stimulating factor 3 receptorprovided by RGD
Primary source: RGD:1309114
See related: EnsemblRapid:ENSRNOG00000008759 AllianceGenome:RGD:1309114
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable cytokine receptor activity and granulocyte colony-stimulating factor binding activity. Involved in amelogenesis. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in hematologic cancer (multiple); hereditary neutrophilia; and severe congenital neutropenia (multiple). Orthologous to human CSF3R (colony stimulating factor 3 receptor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 32.8), Lung (RPKM 24.6) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (143583126..143604382)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (138298605..138318224)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (144031353..144051966)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the expression of GCSFR in neurons following peripheral nerve injury may be involved in the induction and maintenance of neuropathic pain through the STAT3 and TRPV1 signaling pathway.
Title: Expression of granulocyte colony-stimulating factor 3 receptor in the spinal dorsal horn following spinal nerve ligation-induced neuropathic pain.

Submit: New GeneRIF Correction

General gene information

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Markers

Csf3r (e-PCR), detects polymorphism
- UniSTS:256390

AA946110 (e-PCR)
- UniSTS:250349

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables granulocyte colony-stimulating factor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in amelogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of myeloid cell differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: granulocyte colony-stimulating factor receptor

Names: colony stimulating factor 3 receptor (granulocyte)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106685.1 → NP_001100155.1 granulocyte colony-stimulating factor receptor precursor

See identical proteins and their annotated locations for NP_001100155.1

Status: PROVISIONAL

Source sequence(s)

CH473968

UniProtKB/TrEMBL

A6IS82

Conserved Domains (4) summary

smart00060
Location:532 → 609

FN3; Fibronectin type 3 domain

cd00063
Location:433 → 521

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam06328
Location:24 → 111

Lep_receptor_Ig; Ig-like C2-type domain

cl21522
Location:123 → 221

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

143583126..143604382

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039109618.2 → XP_038965546.1 granulocyte colony-stimulating factor receptor isoform X1

UniProtKB/TrEMBL

A0A8I6B3M3

Conserved Domains (4) summary

smart00060
Location:571 → 648

FN3; Fibronectin type 3 domain

cd00063
Location:472 → 560

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam06328
Location:24 → 111

Lep_receptor_Ig; Ig-like C2-type domain

cl21522
Location:123 → 221

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_039109621.2 → XP_038965549.1 granulocyte colony-stimulating factor receptor isoform X2

Conserved Domains (4) summary

smart00060
Location:571 → 648

FN3; Fibronectin type 3 domain

cd00063
Location:472 → 560

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam06328
Location:24 → 111

Lep_receptor_Ig; Ig-like C2-type domain

cl21522
Location:123 → 221

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_039109625.2 → XP_038965553.1 granulocyte colony-stimulating factor receptor isoform X7

Conserved Domains (2) summary

smart00060
Location:438 → 515

FN3; Fibronectin type 3 domain

cd00063
Location:339 → 427

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_039109619.2 → XP_038965547.1 granulocyte colony-stimulating factor receptor isoform X1

UniProtKB/TrEMBL

A0A8I6B3M3

Conserved Domains (4) summary

smart00060
Location:571 → 648

FN3; Fibronectin type 3 domain

cd00063
Location:472 → 560

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam06328
Location:24 → 111

Lep_receptor_Ig; Ig-like C2-type domain

cl21522
Location:123 → 221

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_039109617.2 → XP_038965545.1 granulocyte colony-stimulating factor receptor isoform X1

UniProtKB/TrEMBL

A0A8I6B3M3

Conserved Domains (4) summary

smart00060
Location:571 → 648

FN3; Fibronectin type 3 domain

cd00063
Location:472 → 560

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam06328
Location:24 → 111

Lep_receptor_Ig; Ig-like C2-type domain

cl21522
Location:123 → 221

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_017593289.3 → XP_017448778.1 granulocyte colony-stimulating factor receptor isoform X1

UniProtKB/TrEMBL

A0A8I6B3M3

Related

ENSRNOP00000096023.1, ENSRNOT00000102077.2

Conserved Domains (4) summary

smart00060
Location:571 → 648

FN3; Fibronectin type 3 domain

cd00063
Location:472 → 560

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam06328
Location:24 → 111

Lep_receptor_Ig; Ig-like C2-type domain

cl21522
Location:123 → 221

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_039109622.2 → XP_038965550.1 granulocyte colony-stimulating factor receptor isoform X3

Conserved Domains (4) summary

smart00060
Location:560 → 637

FN3; Fibronectin type 3 domain

cd00063
Location:461 → 549

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam06328
Location:24 → 111

Lep_receptor_Ig; Ig-like C2-type domain

cl21522
Location:123 → 221

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_039109623.2 → XP_038965551.1 granulocyte colony-stimulating factor receptor isoform X4

UniProtKB/TrEMBL

D4A3R0

Related

ENSRNOP00000011694.6, ENSRNOT00000011694.8

Conserved Domains (4) summary

smart00060
Location:543 → 620

FN3; Fibronectin type 3 domain

cd00063
Location:444 → 532

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam06328
Location:24 → 111

Lep_receptor_Ig; Ig-like C2-type domain

cl21522
Location:123 → 221

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_063287439.1 → XP_063143509.1 granulocyte colony-stimulating factor receptor isoform X6
XM_063287437.1 → XP_063143507.1 granulocyte colony-stimulating factor receptor isoform X5

UniProtKB/TrEMBL

A6IS82
XM_008764007.4 → XP_008762229.1 granulocyte colony-stimulating factor receptor isoform X5

See identical proteins and their annotated locations for XP_008762229.1

UniProtKB/TrEMBL

A6IS82

Conserved Domains (4) summary

smart00060
Location:532 → 609

FN3; Fibronectin type 3 domain

cd00063
Location:433 → 521

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam06328
Location:24 → 111

Lep_receptor_Ig; Ig-like C2-type domain

cl21522
Location:123 → 221

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_063287438.1 → XP_063143508.1 granulocyte colony-stimulating factor receptor isoform X5

UniProtKB/TrEMBL

A6IS82
XM_039109620.2 → XP_038965548.1 granulocyte colony-stimulating factor receptor isoform X1

UniProtKB/TrEMBL

A0A8I6B3M3

Conserved Domains (4) summary

smart00060
Location:571 → 648

FN3; Fibronectin type 3 domain

cd00063
Location:472 → 560

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam06328
Location:24 → 111

Lep_receptor_Ig; Ig-like C2-type domain

cl21522
Location:123 → 221

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_039109626.2 → XP_038965554.1 granulocyte colony-stimulating factor receptor isoform X8

Conserved Domains (2) summary

smart00060
Location:393 → 470

FN3; Fibronectin type 3 domain

cd00063
Location:294 → 382

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_039109627.2 → XP_038965555.1 granulocyte colony-stimulating factor receptor isoform X9

Conserved Domains (2) summary

smart00060
Location:252 → 329

FN3; Fibronectin type 3 domain

cd00063
Location:153 → 241

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...