Rnf19a ring finger protein 19A, RBR E3 ubiquitin protein ligase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rnf19aprovided by RGD
Official Full Name: ring finger protein 19A, RBR E3 ubiquitin protein ligaseprovided by RGD
Primary source: RGD:1307807
See related: EnsemblRapid:ENSRNOG00000009658 AllianceGenome:RGD:1307807
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rnf19
Summary: Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Predicted to be involved in regulation of protein catabolic process at postsynapse, modulating synaptic transmission and ubiquitin-dependent protein catabolic process. Predicted to be located in postsynapse. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm; glutamatergic synapse; and hippocampal mossy fiber to CA3 synapse. Orthologous to human RNF19A (ring finger protein 19A, RBR E3 ubiquitin protein ligase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 316.2), Kidney (RPKM 213.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q22

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (69310947..69350567, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (67425833..67465214, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (75058758..75098331, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rnf19a and Psmc3 may interact directly or indirectly with each other, presumably pointing to the participation of the ubiquitin-proteasome system in acrosome biogenesis, spermatid head shaping, and development of the head-tail coupling apparatus and tail.
Title: Rnf19a, a ubiquitin protein ligase, and Psmc3, a component of the 26S proteasome, tether to the acrosome membranes and the head-tail coupling apparatus during rat spermatid development.

Submit: New GeneRIF Correction

General gene information

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Markers

RH141515 (e-PCR)
- UniSTS:223509

AW533310 (e-PCR)
- UniSTS:245975

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ubiquitin conjugating enzyme binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein catabolic process at postsynapse, modulating synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in hippocampal mossy fiber to CA3 synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase RNF19A

Names: ring finger protein (C3HC4 type) 19; ring finger protein 19A, E3 ubiquitin protein ligase

NP_001124032.1

EC 2.3.2.27

XP_063119903.1

EC 2.3.2.27

XP_063119904.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130560.1 → NP_001124032.1 E3 ubiquitin-protein ligase RNF19A

See identical proteins and their annotated locations for NP_001124032.1

Status: PROVISIONAL

Source sequence(s)

CH473950

UniProtKB/TrEMBL

A6HR26, D3ZXM0

Related

ENSRNOP00000013344.4, ENSRNOT00000013344.7

Conserved Domains (5) summary

smart00647
Location:199 → 264

IBR; In Between Ring fingers

cd16775
Location:131 → 185

RING-HC_RBR_RNF19A; RING finger, HC subclass, found in RING finger protein 19A (RNF19A) and similar proteins

pfam01485
Location:297 → 335

IBR; IBR domain, a half RING-finger domain

NF033849
Location:432 → 661

ser_rich_anae_1; serine-rich protein

cl00570
Location:361 → 450

AzlC; AzlC protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

69310947..69350567 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063263833.1 → XP_063119903.1 E3 ubiquitin-protein ligase RNF19A isoform X1

UniProtKB/TrEMBL

A6HR26, D3ZXM0
XM_063263834.1 → XP_063119904.1 E3 ubiquitin-protein ligase RNF19A isoform X2