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    Nqo2 N-ribosyldihydronicotinamide:quinone dehydrogenase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291084, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nqo2provided by RGD
    Official Full Name
    N-ribosyldihydronicotinamide:quinone dehydrogenase 2provided by RGD
    Primary source
    RGD:1303320
    See related
    EnsemblRapid:ENSRNOG00000017820 AllianceGenome:RGD:1303320
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including anion binding activity; dihydronicotinamide riboside quinone reductase activity; and melatonin binding activity. Involved in several processes, including positive regulation of ERK1 and ERK2 cascade; positive regulation of neuron apoptotic process; and positive regulation of vascular associated smooth muscle cell proliferation. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Parkinson's disease; agranulocytosis; breast cancer; and breast carcinoma. Orthologous to human NQO2 (N-ribosyldihydronicotinamide:quinone dehydrogenase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 214.6), Heart (RPKM 157.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nqo2 in Genome Data Viewer
    Location:
    17p12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (31114825..31144062, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (30909482..30938725, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (32131847..32158559, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene biphenyl hydrolase like Neighboring gene receptor interacting serine/threonine kinase 1 Neighboring gene serpin family B member 6A Neighboring gene uncharacterized LOC102554685 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 6e like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Resveratrol inhibits angiotensin II-induced ERK1/2 activation by downregulating quinone reductase 2 in rat vascular smooth muscle cells. Zhang X, et al. J Biomed Res, 2012 Mar. PMID 23554738, Free PMC Article
    2. Downregulation of quinone reductase 2 attenuates vascular smooth muscle cells proliferation and neointimal formation in balloon injured rat carotid artery. Zhang XW, et al. Cell Physiol Biochem, 2012. PMID 22508052
    3. The influence of NQO2 on the dysfunctional autophagy and oxidative stress induced in the hippocampus of rats and in SH-SY5Y cells by fluoride. Ran LY, et al. CNS Neurosci Ther, 2023 Apr. PMID 36650666, Free PMC Article
    4. Association of NRH:quinone oxidoreductase 2 gene promoter polymorphism with higher gene expression and increased susceptibility to Parkinson's disease. Wang W, et al. J Gerontol A Biol Sci Med Sci, 2008 Feb. PMID 18314446
    5. NQO2 gene is associated with clozapine-induced agranulocytosis. Ostrousky O, et al. Tissue Antigens, 2003 Dec. PMID 14617031

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The influence of NQO2 on the dysfunctional autophagy and oxidative stress induced in the hippocampus of rats and in SH-SY5Y cells by fluoride.
      Title: The influence of NQO2 on the dysfunctional autophagy and oxidative stress induced in the hippocampus of rats and in SH-SY5Y cells by fluoride.
    2. Downregulation of NQO2 significantly suppresses vascular smooth muscle cell proliferation and progression of neointimal formation after vascular injury.
      Title: Downregulation of quinone reductase 2 attenuates vascular smooth muscle cells proliferation and neointimal formation in balloon injured rat carotid artery.
    3. these data suggest a role for QR2 in cognitive behaviors
      Title: Loss of quinone reductase 2 function selectively facilitates learning behaviors.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC94180

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables FAD binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NAD(P)H dehydrogenase (quinone) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chloride ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dihydronicotinamide riboside quinone reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables electron transfer activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables melatonin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity, acting on other nitrogenous compounds as donors ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables resveratrol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in memory IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of vascular associated smooth muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in quinone catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ribosyldihydronicotinamide dehydrogenase [quinone]
    Names
    N-ribosyldihydronicotinamide:quinone reductase 2
    NAD(P)H dehydrogenase, quinone 2
    NAD(P)H quinone dehydrogenase 2
    NRH dehydrogenase [quinone] 2
    NRH:quinone oxidoreductase 2
    QR2
    quinone reductase 2
    ribosyldihydronicotinamide dehydrogenase
    NP_001004214.1
    XP_006253929.1
    XP_006253930.1
    XP_038951418.1
    XP_038951419.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004214.1 → NP_001004214.1  ribosyldihydronicotinamide dehydrogenase [quinone]

      See identical proteins and their annotated locations for NP_001004214.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079157
      UniProtKB/Swiss-Prot
      Q6AY80
      UniProtKB/TrEMBL
      A6J7H5
      Related
      ENSRNOP00000024141.5, ENSRNOT00000024141.7
      Conserved Domains (1) summary
      pfam02525
      Location:4 → 212
      Flavodoxin_2; Flavodoxin-like fold

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      31114825..31144062 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253867.5 → XP_006253929.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform X1

      See identical proteins and their annotated locations for XP_006253929.1

      UniProtKB/Swiss-Prot
      Q6AY80
      UniProtKB/TrEMBL
      A6J7H5
      Conserved Domains (1) summary
      pfam02525
      Location:4 → 212
      Flavodoxin_2; Flavodoxin-like fold

    2. XM_039095491.2 → XP_038951419.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform X2

      UniProtKB/TrEMBL
      A6J7H5
      Conserved Domains (1) summary
      pfam02525
      Location:3 → 191
      Flavodoxin_2; Flavodoxin-like fold

    3. XM_006253868.4 → XP_006253930.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform X2

      UniProtKB/TrEMBL
      A6J7H5
      Conserved Domains (1) summary
      pfam02525
      Location:3 → 191
      Flavodoxin_2; Flavodoxin-like fold

    4. XM_039095490.2 → XP_038951418.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform X1

      UniProtKB/Swiss-Prot
      Q6AY80
      UniProtKB/TrEMBL
      A6J7H5
      Conserved Domains (1) summary
      pfam02525
      Location:4 → 212
      Flavodoxin_2; Flavodoxin-like fold
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AY80.3 GenPept UniProtKB/Swiss-Prot:Q6AY80

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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