Cort cortistatin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cortprovided by RGD
Official Full Name: cortistatinprovided by RGD
Primary source: RGD:2383
See related: AllianceGenome:RGD:2383
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables neuropeptide hormone activity. Involved in neuropeptide signaling pathway and regulation of circadian sleep/wake cycle, sleep. Predicted to be active in extracellular space. Biomarker of brain infarction. Orthologous to human CORT (cortistatin). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 43.5) and Muscle (RPKM 1.8) See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (164843682..164845796, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (159560591..159562032, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (165942780..165944221, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

inhibits aortic calcification and osteogenic differentiation of vascular smooth muscle cells likely via the GSK3beta/beta-catenin and PKC signalling pathways, but not JNK signalling pathway
Title: Cortistatin inhibits arterial calcification in rats via GSK3β/β-catenin and protein kinase C signalling but not c-Jun N-terminal kinase signalling.
CST directly inhibited beta-GP-induced calcification of VSMCs in vitro, probably by suppressing ERS and phenotypic transformation of VSMCs into osteoblastic cells.
Title: Cortistatin inhibits calcification of vascular smooth muscle cells by depressing osteoblastic differentiation and endoplasmic reticulum stress.
Oral berberine exerted anti-arthritic effect through inhibiting the Th17 cell response, which was closely associated with the induction of cortistatin generation from gut through augmenting autocrine/paracrine action between enteric nerve cells and endocrine cells.
Title: Berberine ameliorates collagen-induced arthritis in rats by suppressing Th17 cell responses via inducing cortistatin in the gut.
The DDAH/asymmetric dimethylarginine pathway participates in the pathogenesis of rheumatoid arthritis and may be mediated by cortistatin.
Title: Involvement of DDAH/ADMA pathway in the pathogenesis of rheumatoid arthritis in rats.
RT-PCR and immunocytochemistry studies support the presence of cortistatin in rat Kupffer cells.
Title: RT-PCR and immunocytochemistry studies support the presence of somatostatin, cortistatin and somatostatin receptor subtypes in rat Kupffer cells.
The capacity of CST-14 to increase SWA, together with preprocortistatin's inverse correlation with time spent in SWS, suggests a potential role in sleep homeostatic processes.
Title: Cortistatin promotes and negatively correlates with slow-wave sleep.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor binding	ISO Inferred from Sequence Orthology more info
enables neuropeptide hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide hormone activity	IDA Inferred from Direct Assay more info	PubMed
enables neuropeptide hormone activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of circadian sleep/wake cycle, sleep	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cortistatin

Names: Preprocortistatin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012835.1 → NP_036967.1 cortistatin preproprotein

See identical proteins and their annotated locations for NP_036967.1

Status: VALIDATED

Source sequence(s)

U51919

UniProtKB/Swiss-Prot

Q62949

UniProtKB/TrEMBL

A6IU99

Conserved Domains (1) summary

pfam03002
Location:94 → 111

Somatostatin; Somatostatin/Cortistatin family