Tlr6 toll-like receptor 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tlr6provided by RGD
Official Full Name: toll-like receptor 6provided by RGD
Primary source: RGD:1303030
See related: EnsemblRapid:ENSRNOG00000002161 AllianceGenome:RGD:1303030
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables lipopeptide binding activity. Involved in several processes, including microglial cell activation; response to bacterial lipoprotein; and toll-like receptor signaling pathway. Predicted to be located in Golgi apparatus and membrane raft. Predicted to be part of Toll-like receptor 2-Toll-like receptor 6 protein complex. Predicted to be active in plasma membrane. Used to study bacterial pneumonia. Biomarker of perinatal necrotizing enterocolitis. Human ortholog(s) of this gene implicated in aspergillosis; asthma; infective endocarditis; rhinitis; and tuberculosis. Orthologous to human TLR6 (toll like receptor 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 83.7), Thymus (RPKM 35.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p11

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (43715809..43727019)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (43362164..43374500)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (45024351..45041188)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

aortic angiogenesis is preceded by an immune reaction with overexpression of Toll-like receptors (TLRs) and TLR-inducible genes.
Title: Regulation of angiogenesis, mural cell recruitment and adventitial macrophage behavior by Toll-like receptors.
toll-like receptors and nucleotide-binding oligomerization domain 2 combinations are contributors to the signaling cascades resulting in purinergic microglial activation
Title: Combinations of TLR and NOD2 ligands stimulate rat microglial P2X4R expression.
activation of TLR-2 and -6 can induce systemic inflammation in rats accompanied by the classical signs of brain-controlled illness responses
Title: Pyrexia, anorexia, adipsia, and depressed motor activity in rats during systemic inflammation induced by the Toll-like receptors-2 and -6 agonists MALP-2 and FSL-1.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Toll-like receptor 2 binding	IBA Inferred from Biological aspect of Ancestor more info
enables Toll-like receptor 2 binding	ISO Inferred from Sequence Orthology more info
enables diacyl lipopeptide binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipopeptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipopeptide binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables lipopeptide binding	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in MyD88-dependent toll-like receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in TRIF-dependent toll-like receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amyloid-beta	ISO Inferred from Sequence Orthology more info
involved_in cellular response to diacyl bacterial lipopeptide	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to diacyl bacterial lipopeptide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to diacyl bacterial lipopeptide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to oxidised low-density lipoprotein particle stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within detection of diacyl bacterial lipopeptide	ISO Inferred from Sequence Orthology more info
involved_in immune response	TAS Traceable Author Statement more info	PubMed
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in microglial cell activation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of toll-like receptor 2 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in nitric oxide metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of JUN kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NLRP3 inflammasome complex assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of reactive oxygen species biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in response to bacterial lipoprotein	IDA Inferred from Direct Assay more info	PubMed
involved_in toll-like receptor TLR6:TLR2 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in toll-like receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in toll-like receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in toll-like receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
part_of Toll-like receptor 2-Toll-like receptor 6 protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Toll-like receptor 2-Toll-like receptor 6 protein complex	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: toll-like receptor 6

NP_997487.1

EC 3.2.2.6

XP_006251022.1

EC 3.2.2.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_207604.1 → NP_997487.1 toll-like receptor 6

See identical proteins and their annotated locations for NP_997487.1

Status: PROVISIONAL

Source sequence(s)

BC062390

UniProtKB/TrEMBL

G3V695, Q6P690

Conserved Domains (6) summary

smart00082
Location:540 → 594

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:652 → 791

TIR; Toll - interleukin 1 - resistance

cd00116
Location:380 → 500

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00031
Location:65 → 88

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:46 → 64

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:87 → 144

LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

43715809..43727019

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006250960.4 → XP_006251022.1 toll-like receptor 6 isoform X1

See identical proteins and their annotated locations for XP_006251022.1

UniProtKB/TrEMBL

A0A096MKA9, A6JDF8, G3V695

Related

ENSRNOP00000081116.1, ENSRNOT00000108237.2

Conserved Domains (6) summary

smart00082
Location:540 → 594

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:652 → 791

TIR; Toll - interleukin 1 - resistance

cd00116
Location:343 → 500

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00031
Location:65 → 88

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:390 → 415

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:87 → 144

LRR_8; Leucine rich repeat