Lipe lipase E, hormone sensitive type [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lipeprovided by RGD
Official Full Name: lipase E, hormone sensitive typeprovided by RGD
Primary source: RGD:3010
See related: EnsemblRapid:ENSRNOG00000020546 AllianceGenome:RGD:3010
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: HSL; REH
Summary: Enables lipase activity and retinyl-palmitate esterase activity. Involved in female pregnancy; response to xenobiotic stimulus; and triglyceride catabolic process. Located in extracellular space. Used to study arteriosclerosis and heart disease. Biomarker of obesity. Human ortholog(s) of this gene implicated in familial partial lipodystrophy type 6 and hypertension. Orthologous to human LIPE (lipase E, hormone sensitive type). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 240.3), Thymus (RPKM 155.5) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (90093433..90112117, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (80965612..80984313, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (82248031..82266727, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HSL regulates vitamin A metabolism in quiescent hepatic stellate cells.
Title: Hormone-sensitive lipase is a retinyl ester hydrolase in human and rat quiescent hepatic stellate cells.
Habitual exercise training acts as a physiological stimulator for constant activation of lipolytic enzymes, HSL and ATGL, in rat primary white adipocytes.
Title: Habitual exercise training acts as a physiological stimulator for constant activation of lipolytic enzymes in rat primary white adipocytes.
The findings suggest that progesterone, acting in a progesterone receptor-dependent manner, down-regulates Lipe gene expression but exerts no effect on Pnpla2 gene expression in the inguinal white adipose tissue of females.
Title: Progesterone-induced down-regulation of hormone sensitive lipase (Lipe) and up-regulation of G0/G1 switch 2 (G0s2) genes expression in inguinal adipose tissue of female rats is reflected by diminished rate of lipolysis.
These findings suggest that acute exercise enhances lipolysis up to at least 3h after exercise in a manner dependent on modification of HSL and its association with and alteration in scaffold protein.
Title: Hormone-sensitive lipase is critical mediators of acute exercise-induced regulation of lipolysis in rat adipocytes.
When compared with obesity-resistant rats, the gene expression of HSL in white adipose tissue was lower in obesity-prone rats.
Title: [Gene expression of hormone sensitive lipase and lipoprotein lipase in obesity-prone and obesity-resistant rats induced by high-fat diet].
PKA phosphorylation induces a conformational change that increases the exposed hydrophobic surface and thereby facilitates binding of HSL to the lipid substrate.
Title: Phosphorylation of hormone-sensitive lipase by protein kinase A in vitro promotes an increase in its hydrophobic surface area.
The retinyl ester hydrolase activity of rat HSL was found to be higher than that against the hitherto best known HSL substrate, i.e., diacylglycerols.
Title: Hormone-sensitive lipase (HSL) is also a retinyl ester hydrolase: evidence from mice lacking HSL.
HSL labeling in the nucleus of epithelial and germ cells suggests an as yet unknown function for this protein, probably related to oogenesis and cell proliferation.
Title: Hormone-sensitive lipase expression and IHC localization in the rat ovary, oviduct, and uterus.
an 89-kDa isoform of hormone-sensitive lipase (HSL) and its molecular structure is described; the novel HSL isoform is expressed in the pancreatic beta-cell, adipose tissue, adrenal gland, and ovary
Title: A novel hormone-sensitive lipase isoform expressed in pancreatic beta-cells.
hormone-sensitive lipase is involved in mediating beta-cell lipotoxicity by providing ligands for peroxisome proliferator-activated receptors and other lipid-activated transcription factors, which in turn alter the expression of critical genes.
Title: Pancreatic beta-cell lipotoxicity induced by overexpression of hormone-sensitive lipase.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BG381659 (e-PCR)
- UniSTS:249910

RH94620 (e-PCR)
- UniSTS:119868

D1Rat339 (e-PCR), detects polymorphism
- UniSTS:227138

RH131319 (e-PCR)
- UniSTS:214602

D1Bda5 (e-PCR)
- UniSTS:240339

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity	IEA Inferred from Electronic Annotation more info
enables diacylglycerol lipase activity	IDA Inferred from Direct Assay more info	PubMed
enables diacylglycerol lipase activity	IEA Inferred from Electronic Annotation more info
enables diacylglycerol lipase activity	ISO Inferred from Sequence Orthology more info
enables diacylglycerol lipase activity	ISS Inferred from Sequence or Structural Similarity more info
enables hydrolase activity, acting on ester bonds	IDA Inferred from Direct Assay more info	PubMed
enables lipase activity	IEA Inferred from Electronic Annotation more info
enables monoacylglycerol lipase activity	IDA Inferred from Direct Assay more info	PubMed
enables monoacylglycerol lipase activity	IEA Inferred from Electronic Annotation more info
enables monoacylglycerol lipase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables rRNA primary transcript binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables retinyl-palmitate esterase activity	IDA Inferred from Direct Assay more info	PubMed
enables retinyl-palmitate esterase activity	IEA Inferred from Electronic Annotation more info
enables retinyl-palmitate esterase activity	ISO Inferred from Sequence Orthology more info
enables serine hydrolase activity	ISO Inferred from Sequence Orthology more info
enables sterol ester esterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables sterol ester esterase activity	IDA Inferred from Direct Assay more info	PubMed
enables sterol ester esterase activity	IEA Inferred from Electronic Annotation more info
enables sterol ester esterase activity	ISO Inferred from Sequence Orthology more info
enables triacylglycerol lipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables triacylglycerol lipase activity	IDA Inferred from Direct Assay more info	PubMed
enables triacylglycerol lipase activity	IEA Inferred from Electronic Annotation more info
enables triacylglycerol lipase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to cold	ISO Inferred from Sequence Orthology more info
involved_in cholesterol metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within diacylglycerol catabolic process	ISO Inferred from Sequence Orthology more info
involved_in diacylglycerol catabolic process	ISO Inferred from Sequence Orthology more info
involved_in diacylglycerol catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in ether lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in ether lipid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in lipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in lipid catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid catabolic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within long-chain fatty acid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in retinol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in termination of RNA polymerase I transcription	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in transcription initiation at RNA polymerase I promoter	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in triglyceride catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in triglyceride catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in triglyceride catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within triglyceride catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in caveola	IEA Inferred from Electronic Annotation more info
located_in caveola	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in lipid droplet	IEA Inferred from Electronic Annotation more info
located_in lipid droplet	ISO Inferred from Sequence Orthology more info
located_in lipid droplet	ISS Inferred from Sequence or Structural Similarity more info
located_in lipid droplet	TAS Traceable Author Statement more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: hormone-sensitive lipase

Names: lipase, hormone sensitive; monoacylglycerol lipase LIPE; retinyl ester hydrolase

NP_036991.1

EC 3.1.1.23

EC 3.1.1.79

XP_006228453.1

EC 3.1.1.23

EC 3.1.1.79

XP_006228455.1

EC 3.1.1.23

EC 3.1.1.79

XP_006228456.1

EC 3.1.1.23

EC 3.1.1.79

XP_038957507.1

EC 3.1.1.23

EC 3.1.1.79

XP_063137757.1

EC 3.1.1.23

EC 3.1.1.79

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012859.1 → NP_036991.1 hormone-sensitive lipase

See identical proteins and their annotated locations for NP_036991.1

Status: PROVISIONAL

Source sequence(s)

U40001

UniProtKB/Swiss-Prot

P15304, Q6LCQ2

UniProtKB/TrEMBL

A6J957, G3V8R5

Related

ENSRNOP00000027911.1, ENSRNOT00000027910.4

Conserved Domains (3) summary

COG0657
Location:631 → 792

Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

pfam06350
Location:306 → 614

HSL_N; Hormone-sensitive lipase (HSL) N-terminus

cl21494
Location:645 → 793

Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

90093433..90112117 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063281687.1 → XP_063137757.1 hormone-sensitive lipase isoform X1

UniProtKB/TrEMBL

A0A8I6GLP7
XM_006228391.4 → XP_006228453.1 hormone-sensitive lipase isoform X2

UniProtKB/TrEMBL

A0A8I6GLP7

Related

ENSRNOP00000096661.1, ENSRNOT00000099694.2

Conserved Domains (3) summary

COG0657
Location:374 → 535

Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

pfam06350
Location:49 → 357

HSL_N; Hormone-sensitive lipase (HSL) N-terminus

cl21494
Location:388 → 536

Abhydrolase; alpha/beta hydrolases
XM_006228394.5 → XP_006228456.1 hormone-sensitive lipase isoform X4

See identical proteins and their annotated locations for XP_006228456.1

UniProtKB/TrEMBL

A0A8I6GLP7, A6J958

Conserved Domains (3) summary

COG0657
Location:331 → 492

Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

pfam06350
Location:6 → 314

HSL_N; Hormone-sensitive lipase (HSL) N-terminus

cl21494
Location:345 → 493

Abhydrolase; alpha/beta hydrolases
XM_006228393.4 → XP_006228455.1 hormone-sensitive lipase isoform X3

UniProtKB/TrEMBL

A0A8I6GLP7

Conserved Domains (3) summary

COG0657
Location:341 → 502

Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

pfam06350
Location:16 → 324

HSL_N; Hormone-sensitive lipase (HSL) N-terminus

cl21494
Location:355 → 503

Abhydrolase; alpha/beta hydrolases
XM_039101579.2 → XP_038957507.1 hormone-sensitive lipase isoform X5

UniProtKB/TrEMBL

Q6AYV9

Conserved Domains (1) summary

pfam06350
Location:306 → 472

HSL_N; Hormone-sensitive lipase (HSL) N-terminus