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    Tnk1 tyrosine kinase, non-receptor, 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303247, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tnk1provided by RGD
    Official Full Name
    tyrosine kinase, non-receptor, 1provided by RGD
    Primary source
    RGD:1310113
    See related
    EnsemblRapid:ENSRNOG00000015578 AllianceGenome:RGD:1310113
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATP binding activity and non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in negative regulation of Ras protein signal transduction; negative regulation of cell growth; and protein autophosphorylation. Predicted to be located in cytosol and membrane. Predicted to be active in plasma membrane. Orthologous to human TNK1 (tyrosine kinase non receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 24.8), Lung (RPKM 18.9) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tnk1 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (55070362..55084383, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54571396..54580547, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56458650..56475183, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 256 Neighboring gene phospholipid scramblase 3 Neighboring gene transmembrane protein 95 Neighboring gene potassium channel tetramerization domain containing 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Kos1, a nonreceptor tyrosine kinase that suppresses Ras signaling. Hoare K, et al. Oncogene, 2003 Jun 5. PMID 12789265
    2. Characterization of the tyrosine kinase Tnk1 and its binding with phospholipase C-gamma1. Felschow DM, et al. Biochem Biophys Res Commun, 2000 Jun 24. PMID 10873601
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    non-receptor tyrosine-protein kinase TNK1
    NP_001100482.1
    XP_006246766.1
    XP_038941911.1
    XP_063125103.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107012.1 → NP_001100482.1  non-receptor tyrosine-protein kinase TNK1

      See identical proteins and their annotated locations for NP_001100482.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A6HFV1, D3ZJI4
      Related
      ENSRNOP00000097290.2, ENSRNOT00000115677.2
      Conserved Domains (4) summary
      cd09539
      Location:16 → 67
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      cl17036
      Location:395 → 436
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:120 → 380
      PKc_like; Protein Kinases, catalytic domain
      cl21463
      Location:625 → 664
      UBA_like_SF; UBA domain-like superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      55070362..55084383 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246704.5 → XP_006246766.1  non-receptor tyrosine-protein kinase TNK1 isoform X1

      UniProtKB/TrEMBL
      D3ZJI4
      Conserved Domains (4) summary
      cd09539
      Location:89 → 140
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      smart00221
      Location:192 → 451
      STYKc; Protein kinase; unclassified specificity
      cl21453
      Location:193 → 453
      PKc_like; Protein Kinases, catalytic domain
      cl21463
      Location:698 → 737
      UBA_like_SF; UBA domain-like superfamily

    2. XM_063269033.1 → XP_063125103.1  non-receptor tyrosine-protein kinase TNK1 isoform X2

      UniProtKB/TrEMBL
      A6HFV1

    3. XM_039085983.2 → XP_038941911.1  non-receptor tyrosine-protein kinase TNK1 isoform X2

      UniProtKB/TrEMBL
      A6HFV1, D3ZJI4
      Related
      ENSRNOP00000053702.3, ENSRNOT00000056860.4
      Conserved Domains (4) summary
      cd09539
      Location:16 → 67
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      cl17036
      Location:395 → 436
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:120 → 380
      PKc_like; Protein Kinases, catalytic domain
      cl21463
      Location:625 → 664
      UBA_like_SF; UBA domain-like superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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