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    Plekhg1 pleckstrin homology and RhoGEF domain containing G1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 679812, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Plekhg1provided by RGD
    Official Full Name
    pleckstrin homology and RhoGEF domain containing G1provided by RGD
    Primary source
    RGD:1583676
    See related
    EnsemblRapid:ENSRNOG00000016011 AllianceGenome:RGD:1583676
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be located in nucleoplasm. Orthologous to human PLEKHG1 (pleckstrin homology and RhoGEF domain containing G1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Kidney (RPKM 42.0), Lung (RPKM 38.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Plekhg1 in Genome Data Viewer
    Location:
    1p11
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (42612023..42841727)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (40348684..40434063)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (40286908..40521395)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 14c Neighboring gene iodotyrosine deiodinase Neighboring gene 60S ribosomal protein L7a pseudogene Neighboring gene BRMS1, transcriptional repressor and anoikis regulator, pseudogene 1 Neighboring gene cytochrome c, somatic like 1 Neighboring gene methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like Neighboring gene microtubule-associated protein, RP/EB family, member 1, pseudogene 1 Neighboring gene U1 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    pleckstrin homology domain-containing family G member 1
    Names
    pleckstrin homology domain containing, family G (with RhoGef domain) member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190999.2 → NP_001177928.1  pleckstrin homology domain-containing family G member 1

      See identical proteins and their annotated locations for NP_001177928.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      D4AE81
      Conserved Domains (2) summary
      cd13243
      Location:272 → 417
      PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00621
      Location:116 → 291
      RhoGEF; RhoGEF domain

    2. NM_001429014.1 → NP_001415943.1  pleckstrin homology domain-containing family G member 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      D4AE81

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      42612023..42841727
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273325.1 → XP_063129395.1  pleckstrin homology domain-containing family G member 1 isoform X2

      UniProtKB/TrEMBL
      A6KIK4

    2. XM_063273307.1 → XP_063129377.1  pleckstrin homology domain-containing family G member 1 isoform X1

      UniProtKB/TrEMBL
      D4AE81

    3. XM_063273299.1 → XP_063129369.1  pleckstrin homology domain-containing family G member 1 isoform X1

      Related
      ENSRNOP00000101279.1, ENSRNOT00000145879.1

    4. XM_063273321.1 → XP_063129391.1  pleckstrin homology domain-containing family G member 1 isoform X1

      UniProtKB/TrEMBL
      D4AE81

    5. XM_063273310.1 → XP_063129380.1  pleckstrin homology domain-containing family G member 1 isoform X1

      UniProtKB/TrEMBL
      D4AE81

    6. XM_063273314.1 → XP_063129384.1  pleckstrin homology domain-containing family G member 1 isoform X1

      UniProtKB/TrEMBL
      D4AE81

    7. XM_063273318.1 → XP_063129388.1  pleckstrin homology domain-containing family G member 1 isoform X1

      UniProtKB/TrEMBL
      D4AE81

    8. XM_063273303.1 → XP_063129373.1  pleckstrin homology domain-containing family G member 1 isoform X1

    9. XM_063273333.1 → XP_063129403.1  pleckstrin homology domain-containing family G member 1 isoform X3

    RNA

    1. XR_010057385.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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