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    Ppp1r16b protein phosphatase 1, regulatory subunit 16B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 680616, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ppp1r16bprovided by RGD
    Official Full Name
    protein phosphatase 1, regulatory subunit 16Bprovided by RGD
    Primary source
    RGD:1589460
    See related
    EnsemblRapid:ENSRNOG00000015614 AllianceGenome:RGD:1589460
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable enzyme inhibitor activity and myosin phosphatase regulator activity. Predicted to be involved in several processes, including establishment of endothelial barrier; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; and regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be located in several cellular components, including nuclear speck; perinuclear region of cytoplasm; and plasma membrane. Predicted to be active in cytoplasm. Orthologous to human PPP1R16B (protein phosphatase 1 regulatory subunit 16B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 121.7), Brain (RPKM 72.7) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ppp1r16b in Genome Data Viewer
    Location:
    3q42
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (167743518..167839511)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (147323652..147419658)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (155160474..155267002)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 32 member 1 Neighboring gene actin related protein 5 Neighboring gene 60S ribosomal protein L13-like Neighboring gene family with sequence similarity 83, member D Neighboring gene DEAH-box helicase 35

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. TIMAP protects endothelial barrier from LPS-induced vascular leakage and is down-regulated by LPS. Poirier C, et al. Respir Physiol Neurobiol, 2011 Dec 15. PMID 21907835, Free PMC Article
    2. Characterization of the effect of TIMAP phosphorylation on its interaction with protein phosphatase 1. Czikora I, et al. Biochimie, 2011 Jul. PMID 21466834, Free PMC Article
    3. Elongation factor-1A1 is a novel substrate of the protein phosphatase 1-TIMAP complex. Boratkó A, et al. Int J Biochem Cell Biol, 2015 Dec. PMID 26497934
    4. TIMAP promotes angiogenesis by suppressing PTEN-mediated Akt inhibition in human glomerular endothelial cells. Obeidat M, et al. Am J Physiol Renal Physiol, 2014 Sep 1. PMID 25007873
    5. TIMAP is a positive regulator of pulmonary endothelial barrier function. Csortos C, et al. Am J Physiol Lung Cell Mol Physiol, 2008 Sep. PMID 18586956, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables myosin phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in establishment of endothelial barrier IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within establishment of endothelial barrier ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of endothelial barrier ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of sprouting angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase 1 regulatory inhibitor subunit 16B
    Names
    protein phosphatase 1, regulatory (inhibitor) subunit 16B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191072.1 → NP_001178001.1  protein phosphatase 1 regulatory inhibitor subunit 16B

      See identical proteins and their annotated locations for NP_001178001.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      D4AA72
      Related
      ENSRNOP00000021133.4, ENSRNOT00000021133.9
      Conserved Domains (3) summary
      PHA03095
      Location:71 → 301
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:71 → 98
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:72 → 164
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      167743518..167839511
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008762383.4 → XP_008760605.1  protein phosphatase 1 regulatory inhibitor subunit 16B isoform X1

      See identical proteins and their annotated locations for XP_008760605.1

      UniProtKB/TrEMBL
      D4AA72
      Conserved Domains (3) summary
      PHA03095
      Location:71 → 301
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:71 → 98
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:72 → 164
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_017592039.3 → XP_017447528.1  protein phosphatase 1 regulatory inhibitor subunit 16B isoform X2

    3. XM_008762384.3 → XP_008760606.1  protein phosphatase 1 regulatory inhibitor subunit 16B isoform X1

      See identical proteins and their annotated locations for XP_008760606.1

      UniProtKB/TrEMBL
      D4AA72
      Conserved Domains (3) summary
      PHA03095
      Location:71 → 301
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:71 → 98
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:72 → 164
      Ank_2; Ankyrin repeats (3 copies)

    4. XM_039105844.2 → XP_038961772.1  protein phosphatase 1 regulatory inhibitor subunit 16B isoform X1

      UniProtKB/TrEMBL
      D4AA72
      Conserved Domains (3) summary
      PHA03095
      Location:71 → 301
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:71 → 98
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:72 → 164
      Ank_2; Ankyrin repeats (3 copies)

    5. XM_008762385.3 → XP_008760607.1  protein phosphatase 1 regulatory inhibitor subunit 16B isoform X1

      See identical proteins and their annotated locations for XP_008760607.1

      UniProtKB/TrEMBL
      D4AA72
      Conserved Domains (3) summary
      PHA03095
      Location:71 → 301
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:71 → 98
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:72 → 164
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein Strain
    Heading Accession and Version

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