Rbmx RNA binding motif protein, X-linked [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rbmxprovided by RGD
Official Full Name: RNA binding motif protein, X-linkedprovided by RGD
Primary source: RGD:1565256
See related: EnsemblRapid:ENSRNOG00000000866 AllianceGenome:RGD:1565256
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: hnRNP G; hnRNP-G
Summary: Enables single-stranded RNA binding activity. Involved in mRNA splice site recognition; positive regulation of DNA-templated transcription; and regulation of postsynapse organization. Is active in glutamatergic synapse and postsynaptic density. Human ortholog(s) of this gene implicated in X-linked mental retardation Gustavson type and syndromic X-linked intellectual disability Shashi type. Orthologous to human RBMX (RNA binding motif protein X-linked). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 268.1), Kidney (RPKM 150.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq36

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (140342544..140352121, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (135305237..135314806, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (159881835..159891405, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RBMX might play a significant role in the degenerative process of retinal ganglion cells after light-induced damage in the retina.
Title: Expression of RBMX in the light-induced damage of rat retina in vivo.
RBMX immunoreactivity was found in neurons and astrocytes, but not in microglia after spinal cord injury.
Title: Expression of RBMX after spinal cord injury in rats.
hnRNP G is a nuclear protein that is expressed in different concentrations in various tissues and interacts with other splicing regulatory proteins.
Title: Heterogeneous nuclear ribonucleoprotein G regulates splice site selection by binding to CC(A/C)-rich regions in pre-mRNA.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables single-stranded RNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in cellular response to interleukin-1	IEA Inferred from Electronic Annotation more info
involved_in cellular response to interleukin-1	ISO Inferred from Sequence Orthology more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA splice site recognition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane protein ectodomain proteolysis	IEA Inferred from Electronic Annotation more info
involved_in membrane protein ectodomain proteolysis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of alternative mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info
involved_in regulation of alternative mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of catalytic step 2 spliceosome	IEA Inferred from Electronic Annotation more info
part_of catalytic step 2 spliceosome	ISO Inferred from Sequence Orthology more info
located_in euchromatin	IEA Inferred from Electronic Annotation more info
located_in euchromatin	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	EXP Inferred from Experiment more info	PubMed
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
part_of spliceosomal complex	IBA Inferred from Biological aspect of Ancestor more info
part_of supraspliceosomal complex	IEA Inferred from Electronic Annotation more info
part_of supraspliceosomal complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: RNA-binding motif protein, X chromosome

Names: RNA binding motif protein, X chromosome; RNA-binding motif protein, X chromosome retrogene; heterogeneous nuclear ribonucleoprotein G

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025663.2 → NP_001020834.1 RNA-binding motif protein, X chromosome

See identical proteins and their annotated locations for NP_001020834.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

Q4V898

UniProtKB/TrEMBL

A0A8I6AKQ4

Related

ENSRNOP00000001154.6, ENSRNOT00000001154.9

Conserved Domains (3) summary

PRK14086
Location:165 → 302

dnaA; chromosomal replication initiator protein DnaA

pfam08081
Location:173 → 217

RBM1CTR; RBM1CTR (NUC064) family

cd12382
Location:7 → 86

RRM_RBMX_like; RNA recognition motif (RRM) found in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins

RNA

NR_197624.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021
NR_197625.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021
NR_197626.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

140342544..140352121 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006257680.5 → XP_006257742.1 RNA-binding motif protein, X chromosome isoform X1

Conserved Domains (3) summary

PRK14086
Location:165 → 302

dnaA; chromosomal replication initiator protein DnaA

pfam08081
Location:173 → 217

RBM1CTR; RBM1CTR (NUC064) family

cd12382
Location:7 → 86

RRM_RBMX_like; RNA recognition motif (RRM) found in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins
XM_017602020.3 → XP_017457509.2 RNA-binding motif protein, X chromosome isoform X2

Conserved Domains (3) summary

PRK14086
Location:165 → 272

dnaA; chromosomal replication initiator protein DnaA

pfam08081
Location:173 → 217

RBM1CTR; RBM1CTR (NUC064) family

cd12382
Location:7 → 86

RRM_RBMX_like; RNA recognition motif (RRM) found in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins
XM_063279967.1 → XP_063136037.1 RNA-binding motif protein, X chromosome isoform X3
XM_006257682.4 → XP_006257744.1 RNA-binding motif protein, X chromosome isoform X1

Conserved Domains (3) summary

PRK14086
Location:165 → 302

dnaA; chromosomal replication initiator protein DnaA

pfam08081
Location:173 → 217

RBM1CTR; RBM1CTR (NUC064) family

cd12382
Location:7 → 86

RRM_RBMX_like; RNA recognition motif (RRM) found in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins
XM_063279966.1 → XP_063136036.1 RNA-binding motif protein, X chromosome isoform X2
XM_017602021.3 → XP_017457510.1 RNA-binding motif protein, X chromosome isoform X3

Conserved Domains (3) summary

COG0724
Location:1 → 85

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12382
Location:7 → 86

RRM_RBMX_like; RNA recognition motif in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins

pfam08081
Location:173 → 217

RBM1CTR; RBM1CTR (NUC064) family
XM_006257683.5 → XP_006257745.1 RNA-binding motif protein, X chromosome isoform X1

Conserved Domains (3) summary

PRK14086
Location:165 → 302

dnaA; chromosomal replication initiator protein DnaA

pfam08081
Location:173 → 217

RBM1CTR; RBM1CTR (NUC064) family

cd12382
Location:7 → 86

RRM_RBMX_like; RNA recognition motif (RRM) found in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins