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    Nipa2 NIPA magnesium transporter 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308667, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nipa2provided by RGD
    Official Full Name
    NIPA magnesium transporter 2provided by RGD
    Primary source
    RGD:1306051
    See related
    EnsemblRapid:ENSRNOG00000012690 AllianceGenome:RGD:1306051
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    SLC56A2; RGD1306051
    Summary
    Predicted to enable magnesium ion transmembrane transporter activity. Predicted to be involved in magnesium ion transport. Predicted to be located in early endosome and plasma membrane. Predicted to be active in membrane. Orthologous to human NIPA2 (NIPA magnesium transporter 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 147.2), Spleen (RPKM 146.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nipa2 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (115935759..115960034, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (106799979..106824206, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (114346005..114371907, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene NIPA magnesium transporter 1 Neighboring gene cytoplasmic FMR1 interacting protein 1 Neighboring gene U6 spliceosomal RNA Neighboring gene peroxiredoxin 3, pseudogene 1 Neighboring gene uncharacterized LOC108348727 Neighboring gene uncharacterized LOC134483328 Neighboring gene HECT and RLD domain containing E3 ubiquitin protein ligase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Functional characterization of NIPA2, a selective Mg2+ transporter. Goytain A, et al. Am J Physiol Cell Physiol, 2008 Oct. PMID 18667602
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables magnesium ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in magnesium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in magnesium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in magnesium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    magnesium transporter NIPA2
    Names
    non imprinted in Prader-Willi/Angelman syndrome 2 homolog
    solute carrier family 56 member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107518.1 → NP_001100988.1  magnesium transporter NIPA2

      See identical proteins and their annotated locations for NP_001100988.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474036
      UniProtKB/TrEMBL
      A6KD29, D3ZUV1
      Related
      ENSRNOP00000018028.3, ENSRNOT00000018028.6
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 302
      Mg_trans_NIPA; Magnesium transporter NIPA

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      115935759..115960034 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006229295.5 → XP_006229357.1  magnesium transporter NIPA2 isoform X1

      See identical proteins and their annotated locations for XP_006229357.1

      UniProtKB/TrEMBL
      A6KD29, D3ZUV1
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 302
      Mg_trans_NIPA; Magnesium transporter NIPA

    2. XM_006229297.5 → XP_006229359.1  magnesium transporter NIPA2 isoform X1

      See identical proteins and their annotated locations for XP_006229359.1

      UniProtKB/TrEMBL
      A6KD29, D3ZUV1
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 302
      Mg_trans_NIPA; Magnesium transporter NIPA

    3. XM_006229298.5 → XP_006229360.1  magnesium transporter NIPA2 isoform X1

      See identical proteins and their annotated locations for XP_006229360.1

      UniProtKB/TrEMBL
      A6KD29, D3ZUV1
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 302
      Mg_trans_NIPA; Magnesium transporter NIPA

    4. XM_063262371.1 → XP_063118441.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/TrEMBL
      A6KD29, D3ZUV1

    5. XM_039112506.2 → XP_038968434.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/TrEMBL
      A6KD29, D3ZUV1
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 302
      Mg_trans_NIPA; Magnesium transporter NIPA

    6. XM_017589153.3 → XP_017444642.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/TrEMBL
      A6KD29, D3ZUV1
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 302
      Mg_trans_NIPA; Magnesium transporter NIPA

    7. XM_017589154.3 → XP_017444643.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/TrEMBL
      A6KD29, D3ZUV1
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 302
      Mg_trans_NIPA; Magnesium transporter NIPA

    8. XM_063262383.1 → XP_063118453.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/TrEMBL
      A6KD29, D3ZUV1

    9. XM_006229292.5 → XP_006229354.1  magnesium transporter NIPA2 isoform X1

      See identical proteins and their annotated locations for XP_006229354.1

      UniProtKB/TrEMBL
      A6KD29, D3ZUV1
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 302
      Mg_trans_NIPA; Magnesium transporter NIPA

    10. XM_063262375.1 → XP_063118445.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/TrEMBL
      A6KD29, D3ZUV1

    11. XM_063262372.1 → XP_063118442.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/TrEMBL
      A6KD29, D3ZUV1

    12. XM_006229296.5 → XP_006229358.1  magnesium transporter NIPA2 isoform X1

      See identical proteins and their annotated locations for XP_006229358.1

      UniProtKB/TrEMBL
      A6KD29, D3ZUV1
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 302
      Mg_trans_NIPA; Magnesium transporter NIPA
    Nucleotide Protein Strain
    Heading Accession and Version

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