Cel carboxyl ester lipase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Celprovided by RGD
Official Full Name: carboxyl ester lipaseprovided by RGD
Primary source: RGD:2331
See related: EnsemblRapid:ENSRNOG00000010406 AllianceGenome:RGD:2331
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Bal; Bssl
Summary: Enables carboxylic ester hydrolase activity and glycosphingolipid binding activity. Predicted to be involved in ceramide catabolic process; intestinal cholesterol absorption; and pancreatic juice secretion. Located in extracellular space and zymogen granule. Part of protein-containing complex. Human ortholog(s) of this gene implicated in lipomatosis; maturity-onset diabetes of the young type 8; type 1 diabetes mellitus; and type 2 diabetes mellitus. Orthologous to human CEL (carboxyl ester lipase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 4421.0) and Liver (RPKM 1265.1) See more
Orthologs: human mouse all
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Genomic context

Location:: 3p12

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (32281518..32289019, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (11883532..11891035, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (7134021..7141522, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Bile salt-stimulated lipase (BSSL) and PLRP2 is responsible for fat digestion as long as milk is the main food. Milk-borne BSSL is able to compensate for a slower ontogeny of pancreatic BSSL expression in the mouse.
Title: Bile salt-stimulated lipase and pancreatic lipase-related protein 2 are the dominating lipases in neonatal fat digestion in mice and rats.
the distal basic cluster may represent the nonspecific (or pre-micellar) bile salt-binding site susceptible to accommodate primary and secondary bile salts.
Title: Site-directed mutagenesis of the distal basic cluster of pancreatic bile salt-dependent lipase.

Submit: New GeneRIF Correction

General gene information

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Markers

D3Wox12 (e-PCR)
- UniSTS:118132

d3arb3 (e-PCR)
- UniSTS:121772

RH132776 (e-PCR)
- UniSTS:216059

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables acetylesterase activity	IEA Inferred from Electronic Annotation more info
enables carboxylic ester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables glycosphingolipid binding	IDA Inferred from Direct Assay more info	PubMed
enables lysophospholipase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables retinyl-palmitate esterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables retinyl-palmitate esterase activity	IDA Inferred from Direct Assay more info	PubMed
enables sterol ester esterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables sterol ester esterase activity	IDA Inferred from Direct Assay more info	PubMed
enables triacylglycerol lipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables triacylglycerol lipase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in ceramide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ceramide catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ceramide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in intestinal cholesterol absorption	IEA Inferred from Electronic Annotation more info
involved_in intestinal cholesterol absorption	ISO Inferred from Sequence Orthology more info
involved_in pancreatic juice secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in pancreatic juice secretion	IEA Inferred from Electronic Annotation more info
involved_in pancreatic juice secretion	ISO Inferred from Sequence Orthology more info
involved_in retinol metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in zymogen granule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: bile salt-activated lipase

Names: bile salt-stimulated lipase; cholesterol esterase; pancreatic lysophospholipase; sterol esterase

NP_058693.2

EC 3.1.1.13

EC 3.1.1.3

EC 3.1.1.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016997.2 → NP_058693.2 bile salt-activated lipase precursor

See identical proteins and their annotated locations for NP_058693.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

P07882, P14722

UniProtKB/TrEMBL

A6JTP0, G3V7G2

Related

ENSRNOP00000014572.2, ENSRNOT00000014572.6

Conserved Domains (2) summary

COG0657
Location:118 → 247

Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

pfam00135
Location:26 → 542

COesterase; Carboxylesterase family