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    Josd2 Josephin domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292876, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Josd2provided by RGD
    Official Full Name
    Josephin domain containing 2provided by RGD
    Primary source
    RGD:1307305
    See related
    EnsemblRapid:ENSRNOG00000019442 AllianceGenome:RGD:1307305
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307305
    Summary
    Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in protein deubiquitination. Orthologous to human JOSD2 (Josephin domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 114.2), Brain (RPKM 88.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Josd2 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (104097382..104101271)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (94960867..94964751)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (100473426..100477352)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108349570 Neighboring gene leucine rich repeat containing 4B Neighboring gene aspartate dehydrogenase domain containing Neighboring gene transfer RNA alanine (anticodon AGC) 69 Neighboring gene ER membrane protein complex subunit 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of a Josephin-ubiquitin complex: evolutionary restraints on ataxin-3 deubiquitinating activity. Weeks SD, et al. J Biol Chem, 2011 Feb 11. PMID 21118805, Free PMC Article
    2. Gene expression profile of the rat eye iridocorneal angle: NEIBank expressed sequence tag analysis. Ahmed F, et al. Invest Ophthalmol Vis Sci, 2004 Sep. PMID 15326124
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    josephin-2
    Names
    Josephin-2
    NP_001099726.2
    XP_006229058.1
    XP_006229059.1
    XP_006229060.1
    XP_038960714.1
    XP_038960715.1
    XP_063139996.1
    XP_063139998.1
    XP_063140001.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106256.2 → NP_001099726.2  josephin-2

      See identical proteins and their annotated locations for NP_001099726.2

      Status: PROVISIONAL

      Source sequence(s)
      CK842299, DV214517
      UniProtKB/TrEMBL
      A6JAP3
      Conserved Domains (1) summary
      pfam02099
      Location:19 → 166
      Josephin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      104097382..104101271
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006228996.5 → XP_006229058.1  josephin-2 isoform X1

      UniProtKB/TrEMBL
      D4AD44
      Related
      ENSRNOP00000026379.5, ENSRNOT00000026379.7
      Conserved Domains (1) summary
      pfam02099
      Location:58 → 205
      Josephin; Josephin

    2. XM_006228997.5 → XP_006229059.1  josephin-2 isoform X2

      Conserved Domains (1) summary
      pfam02099
      Location:57 → 204
      Josephin; Josephin

    3. XM_039104786.2 → XP_038960714.1  josephin-2 isoform X4

      Conserved Domains (1) summary
      pfam02099
      Location:58 → 163
      Josephin

    4. XM_063283926.1 → XP_063139996.1  josephin-2 isoform X5

    5. XM_063283931.1 → XP_063140001.1  josephin-2 isoform X6

      UniProtKB/TrEMBL
      A0A8I6GJF0
      Related
      ENSRNOP00000091200.1, ENSRNOT00000118261.2

    6. XM_063283928.1 → XP_063139998.1  josephin-2 isoform X6

      UniProtKB/TrEMBL
      A0A8I6GJF0

    7. XM_006228998.5 → XP_006229060.1  josephin-2 isoform X3

      See identical proteins and their annotated locations for XP_006229060.1

      UniProtKB/TrEMBL
      A6JAP3
      Conserved Domains (1) summary
      pfam02099
      Location:19 → 166
      Josephin

    8. XM_039104787.2 → XP_038960715.1  josephin-2 isoform X7

      UniProtKB/TrEMBL
      A6JAP7
      Conserved Domains (1) summary
      pfam02099
      Location:2 → 93
      Josephin
    Nucleotide Protein Strain
    Heading Accession and Version

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