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    Gtf2ird2 GTF2I repeat domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288606, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gtf2ird2provided by RGD
    Official Full Name
    GTF2I repeat domain containing 2provided by RGD
    Primary source
    RGD:1307435
    See related
    EnsemblRapid:ENSRNOG00000001482 AllianceGenome:RGD:1307435
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307435; RGD1566086
    Summary
    Predicted to act upstream of or within transition between fast and slow fiber. Predicted to be located in nucleus. Orthologous to human GTF2IRD2B (GTF2I repeat domain containing 2B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 34.4), Brain (RPKM 33.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gtf2ird2 in Genome Data Viewer
    Location:
    12q12
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (28134199..28179089, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (22497767..22536455, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (25509059..25555554, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene general transcription factor II I Neighboring gene neutrophil cytosolic factor 1 Neighboring gene uncharacterized LOC134481282 Neighboring gene RCC1 like Neighboring gene cytosolic arginine sensor for mTORC1 subunit 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. GTF2IRD2 from the Williams-Beuren critical region encodes a mobile-element-derived fusion protein that antagonizes the action of its related family members. Palmer SJ, et al. J Cell Sci, 2012 Nov 1. PMID 22899722, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within transition between fast and slow fiber ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    general transcription factor II-I repeat domain-containing protein 2B
    Names
    general transcription factor II I repeat domain-containing 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001393697.1 → NP_001380626.1  general transcription factor II-I repeat domain-containing protein 2B

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A0A8I5ZN25
      Related
      ENSRNOP00000088990.2, ENSRNOT00000113330.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      28134199..28179089 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271158.1 → XP_063127228.1  general transcription factor II-I repeat domain-containing protein 2B isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZN25, A0A8I6A695
      Related
      ENSRNOP00000079418.2, ENSRNOT00000115001.2

    2. XM_063271159.1 → XP_063127229.1  general transcription factor II-I repeat domain-containing protein 2B isoform X2

      UniProtKB/TrEMBL
      A6J0K6

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001271485.1: Suppressed sequence

      Description
      NM_001271485.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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    Research Materials