Ces1d carboxylesterase 1D [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ces1dprovided by RGD
Official Full Name: carboxylesterase 1Dprovided by RGD
Primary source: RGD:70896
See related: EnsemblRapid:ENSRNOG00000015438 AllianceGenome:RGD:70896
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ces3
Summary: Enables retinyl-palmitate esterase activity. Predicted to be involved in several processes, including cellular response to cholesterol; cholesterol homeostasis; and regulation of steroid metabolic process. Predicted to act upstream of or within several processes, including cellular lipid catabolic process; circadian temperature homeostasis; and cold-induced thermogenesis. Located in intracellular membrane-bounded organelle. Biomarker of liver cancer. Human ortholog(s) of this gene implicated in colorectal cancer and gastrointestinal system cancer. Orthologous to human CES1 (carboxylesterase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 1509.9), Lung (RPKM 1198.8) and 6 other tissues See more
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Genomic context

Location:: 19p11

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (30046494..30085039)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (13873490..13912035)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (15195514..15239827)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity	IEA Inferred from Electronic Annotation more info
enables carboxylesterase activity	ISO Inferred from Sequence Orthology more info
enables carboxylic ester hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables carboxylic ester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables carboxylic ester hydrolase activity	ISO Inferred from Sequence Orthology more info
enables fatty-acyl-ethyl-ester synthase activity	IEA Inferred from Electronic Annotation more info
enables retinyl-palmitate esterase activity	IDA Inferred from Direct Assay more info	PubMed
enables sterol ester esterase activity	ISO Inferred from Sequence Orthology more info
enables sterol ester esterase activity	ISS Inferred from Sequence or Structural Similarity more info
enables triacylglycerol lipase activity	ISO Inferred from Sequence Orthology more info
enables triacylglycerol lipase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in acylglycerol catabolic process	ISO Inferred from Sequence Orthology more info
involved_in acylglycerol catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to cholesterol	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to cold	ISO Inferred from Sequence Orthology more info
involved_in cellular response to low-density lipoprotein particle stimulus	ISO Inferred from Sequence Orthology more info
involved_in cholesterol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within circadian temperature homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cytosolic lipolysis	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in lipid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in medium-chain fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cholesterol storage	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cholesterol efflux	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of bile acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of bile acid secretion	ISO Inferred from Sequence Orthology more info
involved_in retinoid metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in retinol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in reverse cholesterol transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within short-chain fatty acid catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within very-low-density lipoprotein particle assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum lumen	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum lumen	ISS Inferred from Sequence or Structural Similarity more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info	PubMed
is_active_in lipid droplet	IBA Inferred from Biological aspect of Ancestor more info
located_in lipid droplet	ISO Inferred from Sequence Orthology more info
located_in lipid droplet	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: carboxylesterase 1D

Names: ES-HVEL; FAEE synthase; carboxyesterase ES-10; carboxylesterase 3; fatty acid ethyl ester synthase; liver carboxylesterase 10; pI 6.1 esterase

NP_579829.3

EC 3.1.1.1

EC 3.1.1.67

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.