Dcx doublecortin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dcxprovided by RGD
Official Full Name: doublecortinprovided by RGD
Primary source: RGD:620670
See related: EnsemblRapid:ENSRNOG00000047712 AllianceGenome:RGD:620670
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains, which bind microtubules and regulate microtubule polymerization. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. Studies in knockout mice lacking this gene suggest that this gene has a cortical role in nuclear translocation and positioning of the mitotic spindle in radial glial mitotic division. This gene is essential for neuronal migration, differentiation, and plasticity, is required for hippocampal development and also plays a role in dendrites development.[provided by RefSeq, Sep 2010]
Expression: Biased expression in Brain (RPKM 85.5), Testes (RPKM 19.7) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq33-q34

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (112227455..112370291, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (107430767..107573612, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (115098675..115175515, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Chlorpromazine affects the numbers of Sox-2, Musashi1 and DCX-expressing cells in the rat brain subventricular zone.
Title: Chlorpromazine affects the numbers of Sox-2, Musashi1 and DCX-expressing cells in the rat brain subventricular zone.
MicroRNA-203-mediated inhibition of doublecortin underpins cardioprotection conferred by sevoflurane in rats after myocardial ischaemia-reperfusion injury.
Title: MicroRNA-203-mediated inhibition of doublecortin underpins cardioprotection conferred by sevoflurane in rats after myocardial ischaemia-reperfusion injury.
Doublecortin and IGF-1R protein levels are reduced in spite of unchanged DNA methylation in the hippocampus of aged rats.
Title: Doublecortin and IGF-1R protein levels are reduced in spite of unchanged DNA methylation in the hippocampus of aged rats.
EXPRESSION OF DOUBLECORTIN AND NeuN IN THE DEVELOPING CEREBELLAR NEURONS IN RAT
Title: [EXPRESSION OF DOUBLECORTIN AND NeuN IN THE DEVELOPING CEREBELLAR NEURONS IN RAT].
The expression of Dcx was found to be a reliable marker of grafted neurons in spinal cord.
Title: Time course of spinal doublecortin expression in developing rat and porcine spinal cord: implication in in vivo neural precursor grafting studies.
The total number of DCX-expressing cells was 1,032, 1,219, and 1,904 in Group P, Group G, and Group C, respectively.
Title: Acute stress exposure preceding global brain ischemia accelerates decreased doublecortin expression in the rat retrosplenial cortex.
Dcx protein- and mRNA-levels reflected changes in neurogenesis
Title: Analysis of adult neurogenesis: evidence for a prominent "non-neurogenic" DCX-protein pool in rodent brain.
DCX+DCLK depletion alters the behavior of growth cones at substrate borders.
Title: A novel role for doublecortin and doublecortin-like kinase in regulating growth cone microtubules.
Dcx protein levels in the cerebella of iodine-deficient & PTU-treated rats were significantly downregulated on PND14 but upregulated on PND21 & 28.
Title: Perinatal iodine deficiency and hypothyroidism increase cell apoptosis and alter doublecortin and reelin protein expressions in rat cerebellum.
Stress-related decrease in doublecortin expression may reduce plasticity potential within the retrosplenial cortex and attenuate spatial learning and memory function.
Title: Decrease in doublecortin expression without neuronal cell death in rat retrosplenial cortex after stress exposure.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in axon extension	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within axon extension	ISO Inferred from Sequence Orthology more info
involved_in axoneme assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within brain development	ISO Inferred from Sequence Orthology more info
involved_in central nervous system projection neuron axonogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within central nervous system projection neuron axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in dendrite morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dendrite morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in hippocampus development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hippocampus development	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in layer formation in cerebral cortex	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within layer formation in cerebral cortex	ISO Inferred from Sequence Orthology more info
involved_in neuron migration	IEA Inferred from Electronic Annotation more info
involved_in neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron migration	ISO Inferred from Sequence Orthology more info
involved_in neuron migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of collateral sprouting	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pyramidal neuron development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pyramidal neuron development	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynapse assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynapse assembly	ISO Inferred from Sequence Orthology more info
involved_in response to electrical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in retina development in camera-type eye	IEA Inferred from Electronic Annotation more info
involved_in spinal cord development	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: neuronal migration protein doublecortin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053379.3 → NP_445831.3 neuronal migration protein doublecortin

See identical proteins and their annotated locations for NP_445831.3

Status: REVIEWED

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

Q9ESI7

UniProtKB/TrEMBL

A6KG86, G3V997

Related

ENSRNOP00000065381.1, ENSRNOT00000074322.3

Conserved Domains (3) summary

cd16112
Location:51 → 139

DCX1_DCX; Dublecortin-like domain 1 found in neuronal migration protein doublecortin (DCX)

cd17069
Location:176 → 259

DCX2; Dublecortin-like domain 2

cl40450
Location:284 → 343

KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

112227455..112370291 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039100106.2 → XP_038956034.1 neuronal migration protein doublecortin isoform X1

UniProtKB/Swiss-Prot

Q9ESI7

Conserved Domains (3) summary

cd16112
Location:51 → 139

DCX1_DCX; Dublecortin-like domain 1 found in neuronal migration protein doublecortin (DCX)

cd17069
Location:176 → 259

DCX2; Dublecortin-like domain 2

cl40450
Location:284 → 343

KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins
XM_006257386.5 → XP_006257448.1 neuronal migration protein doublecortin isoform X2

UniProtKB/Swiss-Prot

Q9ESI7

Conserved Domains (3) summary

cd16112
Location:51 → 139

DCX1_DCX; Dublecortin-like domain 1 found in neuronal migration protein doublecortin (DCX)

cd17069
Location:176 → 259

DCX2; Dublecortin-like domain 2

cl40450
Location:284 → 338

KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins
XM_063280337.1 → XP_063136407.1 neuronal migration protein doublecortin isoform X3

UniProtKB/Swiss-Prot

Q9ESI7
XM_063280339.1 → XP_063136409.1 neuronal migration protein doublecortin isoform X5

UniProtKB/TrEMBL

A0A8I6GLD6, A6KG88
XM_063280338.1 → XP_063136408.1 neuronal migration protein doublecortin isoform X4

UniProtKB/TrEMBL

A6KG88
XM_006257385.5 → XP_006257447.1 neuronal migration protein doublecortin isoform X1

See identical proteins and their annotated locations for XP_006257447.1

UniProtKB/Swiss-Prot

Q9ESI7

Conserved Domains (3) summary

cd16112
Location:51 → 139

DCX1_DCX; Dublecortin-like domain 1 found in neuronal migration protein doublecortin (DCX)

cd17069
Location:176 → 259

DCX2; Dublecortin-like domain 2

cl40450
Location:284 → 343

KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins
XM_006257382.4 → XP_006257444.1 neuronal migration protein doublecortin isoform X1

See identical proteins and their annotated locations for XP_006257444.1

UniProtKB/Swiss-Prot

Q9ESI7

Conserved Domains (3) summary

cd16112
Location:51 → 139

DCX1_DCX; Dublecortin-like domain 1 found in neuronal migration protein doublecortin (DCX)

cd17069
Location:176 → 259

DCX2; Dublecortin-like domain 2

cl40450
Location:284 → 343

KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins
XM_017602167.3 → XP_017457656.1 neuronal migration protein doublecortin isoform X1

UniProtKB/Swiss-Prot

Q9ESI7

Conserved Domains (3) summary

cd16112
Location:51 → 139

DCX1_DCX; Dublecortin-like domain 1 found in neuronal migration protein doublecortin (DCX)

cd17069
Location:176 → 259

DCX2; Dublecortin-like domain 2

cl40450
Location:284 → 343

KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins