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    Il5ra interleukin 5 receptor subunit alpha [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114103, updated on 27-Dec-2024

    Summary

    Official Symbol
    Il5raprovided by RGD
    Official Full Name
    interleukin 5 receptor subunit alphaprovided by RGD
    Primary source
    RGD:70938
    See related
    EnsemblRapid:ENSRNOG00000005954 AllianceGenome:RGD:70938
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable interleukin-5 receptor activity. Predicted to be involved in interleukin-5-mediated signaling pathway. Predicted to act upstream of or within inflammatory response to antigenic stimulus and regulation of interleukin-5 production. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in asthma. Orthologous to human IL5RA (interleukin 5 receptor subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 10.8), Thymus (RPKM 3.5) and 3 other tissues See more
    Orthologs
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    Genomic context

    See Il5ra in Genome Data Viewer
    Location:
    4q41
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (141186749..141221348, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (139630652..139664593, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (138796165..138834164, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene contactin 4 Neighboring gene uncharacterized LOC120102501 Neighboring gene uncharacterized LOC120102502 Neighboring gene U6 spliceosomal RNA Neighboring gene tRNA nucleotidyl transferase 1 Neighboring gene cereblon

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cytokine receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables interleukin-5 receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    interleukin-5 receptor subunit alpha
    Names
    interleukin 5 receptor, alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053645.1NP_446097.1  interleukin-5 receptor subunit alpha precursor

      See identical proteins and their annotated locations for NP_446097.1

      Status: PROVISIONAL

      Source sequence(s)
      AB056101
      UniProtKB/TrEMBL
      A6IBK1, Q920B8, Q99PS3
      Related
      ENSRNOP00000008403.2, ENSRNOT00000008403.5
      Conserved Domains (1) summary
      pfam09240
      Location:124231
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      141186749..141221348 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006236977.5XP_006237039.1  interleukin-5 receptor subunit alpha isoform X1

      UniProtKB/TrEMBL
      A6IBK1, G3V6S7
      Related
      ENSRNOP00000085475.2, ENSRNOT00000117395.2
      Conserved Domains (1) summary
      pfam09240
      Location:158265
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding