Rhou ras homolog family member U [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Rhouprovided by RGD
Full Name: ras homolog family member Uprovided by RGD
Primary source: RGD:1596918
See related: EnsemblRapid:ENSRNOG00000062578 AllianceGenome:RGD:1596918
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rhoul1
Summary: Predicted to enable GTPase activity. Predicted to be involved in cytoskeleton organization and positive regulation of protein targeting to mitochondrion. Predicted to act upstream of or within several processes, including G1/S transition of mitotic cell cycle; Rac protein signal transduction; and regulation of cell shape. Orthologous to human RHOU (ras homolog family member U). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 307.9), Liver (RPKM 256.6) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (68538960..68548733)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (51641476..51651249)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (56431787..56443896)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

AA963604 (e-PCR)
- UniSTS:248098

RH138970 (e-PCR)
- UniSTS:221056

AI182090 (e-PCR)
- UniSTS:179850

RH140287 (e-PCR)
- UniSTS:222365

RH141930 (e-PCR)
- UniSTS:223921

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Cdc42 protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within Rac protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of cell polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein targeting to mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: rho-related GTP-binding protein RhoU

Names: ras homolog family member U-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.