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    Rdh13 retinol dehydrogenase 13 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361504, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rdh13provided by RGD
    Official Full Name
    retinol dehydrogenase 13provided by RGD
    Primary source
    RGD:1304959
    See related
    EnsemblRapid:ENSRNOG00000027919 AllianceGenome:RGD:1304959
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable all-trans-retinol dehydrogenase (NADP+) activity. Predicted to be involved in retinal metabolic process. Predicted to act upstream of or within eye photoreceptor cell development; response to high light intensity; and retina layer formation. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial inner membrane. Orthologous to human RDH13 (retinol dehydrogenase 13). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 88.0), Muscle (RPKM 68.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rdh13 in Genome Data Viewer
    Location:
    1q12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (78415765..78444116)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (69373014..69401454)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (72956017..72983811)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 12C Neighboring gene EPS8-like 1 Neighboring gene glycoprotein VI Neighboring gene NLR family pyrin domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Retinol dehydrogenase 13 protects the mouse retina from acute light damage. Wang H, et al. Mol Vis, 2012. PMID 22605914, Free PMC Article
    2. Human retinol dehydrogenase 13 (RDH13) is a mitochondrial short-chain dehydrogenase/reductase with a retinaldehyde reductase activity. Belyaeva OV, et al. FEBS J, 2008 Jan. PMID 18039331, Free PMC Article
    3. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables all-trans-retinol dehydrogenase (NADP+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables all-trans-retinol dehydrogenase (NADP+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within eye photoreceptor cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to high light intensity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within retina layer formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retinal metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retinal metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retinol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    retinol dehydrogenase 13
    Names
    retinol dehydrogenase 13 (all-trans and 9-cis)
    retinol dehydrogenase 13 (all-trans/9-cis)
    NP_001101938.1
    XP_038937443.1
    XP_038937448.1
    XP_038937451.1
    XP_038937452.1
    XP_038937458.1
    XP_038937461.1
    XP_063122389.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108468.1 → NP_001101938.1  retinol dehydrogenase 13 precursor

      See identical proteins and their annotated locations for NP_001101938.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474075
      UniProtKB/TrEMBL
      A6KNL3, D3ZFR9
      Related
      ENSRNOP00000031331.4, ENSRNOT00000031462.7
      Conserved Domains (1) summary
      cl21454
      Location:38 → 313
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      78415765..78444116
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266319.1 → XP_063122389.1  retinol dehydrogenase 13 isoform X4

    2. XM_039081533.2 → XP_038937461.1  retinol dehydrogenase 13 isoform X5

      Conserved Domains (1) summary
      cl21454
      Location:38 → 117
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    3. XM_039081515.2 → XP_038937443.1  retinol dehydrogenase 13 isoform X1

      Conserved Domains (1) summary
      cl21454
      Location:38 → 242
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    4. XM_039081520.2 → XP_038937448.1  retinol dehydrogenase 13 isoform X2

      Conserved Domains (1) summary
      cl21454
      Location:38 → 207
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    5. XM_039081524.2 → XP_038937452.1  retinol dehydrogenase 13 isoform X3

      Conserved Domains (1) summary
      cl21454
      Location:1 → 186
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    6. XM_039081523.2 → XP_038937451.1  retinol dehydrogenase 13 isoform X3

      Conserved Domains (1) summary
      cl21454
      Location:1 → 186
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    7. XM_039081530.2 → XP_038937458.1  retinol dehydrogenase 13 isoform X3

      Conserved Domains (1) summary
      cl21454
      Location:1 → 186
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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