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    Plekha1 pleckstrin homology domain containing A1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361659, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Plekha1provided by RGD
    Official Full Name
    pleckstrin homology domain containing A1provided by RGD
    Primary source
    RGD:1564153
    See related
    EnsemblRapid:ENSRNOG00000020497 AllianceGenome:RGD:1564153
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564153
    Summary
    Predicted to enable PDZ domain binding activity; phosphatidylinositol-3,4-bisphosphate binding activity; and phospholipid binding activity. Predicted to be involved in several processes, including B cell receptor signaling pathway; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to act upstream of or within several processes, including face morphogenesis; gonad development; and steroid metabolic process. Predicted to be located in cytosol; nucleoplasm; and ruffle membrane. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human PLEKHA1 (pleckstrin homology domain containing A1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Lung (RPKM 273.5), Brain (RPKM 211.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Plekha1 in Genome Data Viewer
    Location:
    1q41
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (194858239..194909418)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (185427982..185479157)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (201429716..201481411)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene transforming, acidic coiled-coil containing protein 2 Neighboring gene uncharacterized LOC134483936 Neighboring gene BTB domain containing 16 Neighboring gene uncharacterized LOC134485181 Neighboring gene HtrA serine peptidase 1 Neighboring gene deleted in malignant brain tumors 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The phosphoinositol 3,4-bisphosphate-binding protein TAPP1 interacts with syntrophins and regulates actin cytoskeletal organization. Hogan A, et al. J Biol Chem, 2004 Dec 17. PMID 15485858
    2. TAPP1 and TAPP2 are targets of phosphatidylinositol 3-kinase signaling in B cells: sustained plasma membrane recruitment triggered by the B-cell antigen receptor. Marshall AJ, et al. Mol Cell Biol, 2002 Aug. PMID 12101241, Free PMC Article
    3. Mechanistic basis of differential cellular responses of phosphatidylinositol 3,4-bisphosphate- and phosphatidylinositol 3,4,5-trisphosphate-binding pleckstrin homology domains. Manna D, et al. J Biol Chem, 2007 Nov 2. PMID 17823121
    4. Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo. Kimber WA, et al. Biochem J, 2002 Feb 1. PMID 11802782, Free PMC Article
    5. Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1. Kimber WA, et al. Biochem J, 2003 Dec 1. PMID 14516276, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC156706

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3,4-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,4-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in B cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within Leydig cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within androgen metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within estrogen metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within face morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within female gonad development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within luteinization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within post-embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within roof of mouth development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ruffle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within skeletal system morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    pleckstrin homology domain-containing family A member 1
    Names
    pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
    pleckstrin homology domain-containing protein family A member 1
    tandem PH domain containing protein-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079894.2 → NP_001073363.1  pleckstrin homology domain-containing family A member 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I5ZUX8, A1A5P7
      Related
      ENSRNOP00000027836.3, ENSRNOT00000027836.6
      Conserved Domains (3) summary
      cd13270
      Location:1 → 117
      PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
      cd13271
      Location:185 → 296
      PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
      pfam00169
      Location:192 → 288
      PH; PH domain

    2. NM_001415980.1 → NP_001402909.1  pleckstrin homology domain-containing family A member 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      194858239..194909418
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267889.1 → XP_063123959.1  pleckstrin homology domain-containing family A member 1 isoform X10

    2. XM_039083107.2 → XP_038939035.1  pleckstrin homology domain-containing family A member 1 isoform X1

      Conserved Domains (2) summary
      cd13270
      Location:1 → 117
      PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
      cd13271
      Location:195 → 306
      PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat

    3. XM_039083132.2 → XP_038939060.1  pleckstrin homology domain-containing family A member 1 isoform X4

      Conserved Domains (2) summary
      cd13270
      Location:1 → 117
      PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
      cd13271
      Location:195 → 306
      PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat

    4. XM_006230412.5 → XP_006230474.1  pleckstrin homology domain-containing family A member 1 isoform X6

      Conserved Domains (3) summary
      cd13270
      Location:1 → 117
      PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
      cd13271
      Location:195 → 306
      PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
      pfam00169
      Location:202 → 298
      PH; PH domain

    5. XM_006230413.5 → XP_006230475.1  pleckstrin homology domain-containing family A member 1 isoform X9

      Conserved Domains (3) summary
      cd13271
      Location:195 → 306
      PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
      pfam00169
      Location:202 → 298
      PH; PH domain
      cl17171
      Location:1 → 117
      PH-like; Pleckstrin homology-like domain

    6. XM_006230409.5 → XP_006230471.1  pleckstrin homology domain-containing family A member 1 isoform X2

      Conserved Domains (3) summary
      cd13270
      Location:1 → 117
      PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
      cd13271
      Location:195 → 306
      PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
      pfam00169
      Location:202 → 298
      PH; PH domain

    7. XM_039083129.2 → XP_038939057.1  pleckstrin homology domain-containing family A member 1 isoform X3

      Conserved Domains (2) summary
      cd13270
      Location:1 → 117
      PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
      cd13271
      Location:185 → 296
      PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat

    8. XM_039083140.2 → XP_038939068.1  pleckstrin homology domain-containing family A member 1 isoform X7

      Conserved Domains (2) summary
      cd13270
      Location:1 → 117
      PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
      cd13271
      Location:185 → 296
      PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat

    9. XM_039083142.2 → XP_038939070.1  pleckstrin homology domain-containing family A member 1 isoform X8

      Related
      ENSRNOP00000108006.1, ENSRNOT00000147430.1
      Conserved Domains (2) summary
      cd13270
      Location:1 → 117
      PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
      cd13271
      Location:185 → 296
      PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat

    10. XM_063267882.1 → XP_063123952.1  pleckstrin homology domain-containing family A member 1 isoform X5

      UniProtKB/TrEMBL
      A6IA45
      Related
      ENSRNOP00000112187.1, ENSRNOT00000132546.1

    11. XM_039083154.2 → XP_038939082.1  pleckstrin homology domain-containing family A member 1 isoform X11

      Conserved Domains (2) summary
      cd13271
      Location:147 → 258
      PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
      cl17171
      Location:1 → 75
      PH-like; Pleckstrin homology-like domain

    12. XM_039083170.2 → XP_038939098.1  pleckstrin homology domain-containing family A member 1 isoform X13

      Conserved Domains (2) summary
      cd13271
      Location:137 → 248
      PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
      cl17171
      Location:1 → 75
      PH-like; Pleckstrin homology-like domain

    13. XM_039083173.2 → XP_038939101.1  pleckstrin homology domain-containing family A member 1 isoform X15

      Conserved Domains (2) summary
      cd13271
      Location:137 → 248
      PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
      cl17171
      Location:1 → 75
      PH-like; Pleckstrin homology-like domain

    14. XM_039083180.2 → XP_038939108.1  pleckstrin homology domain-containing family A member 1 isoform X17

      Conserved Domains (2) summary
      cd13271
      Location:137 → 248
      PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
      cl17171
      Location:1 → 75
      PH-like; Pleckstrin homology-like domain

    15. XM_063267892.1 → XP_063123962.1  pleckstrin homology domain-containing family A member 1 isoform X14

      UniProtKB/TrEMBL
      A0A0G2K1A8, A6IA46
      Related
      ENSRNOP00000071765.2, ENSRNOT00000078244.3

    16. XM_039083163.2 → XP_038939091.1  pleckstrin homology domain-containing family A member 1 isoform X12

      UniProtKB/TrEMBL
      A0A8I5ZUX8
      Conserved Domains (2) summary
      cd13270
      Location:1 → 117
      PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
      cd13271
      Location:195 → 306
      PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat

    17. XM_006230415.5 → XP_006230477.1  pleckstrin homology domain-containing family A member 1 isoform X16

      UniProtKB/TrEMBL
      A0A8I5ZUX8
      Related
      ENSRNOP00000105363.1, ENSRNOT00000149718.1
      Conserved Domains (3) summary
      cd13270
      Location:1 → 117
      PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
      cd13271
      Location:195 → 306
      PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
      pfam00169
      Location:202 → 298
      PH; PH domain

    18. XM_039083114.2 → XP_038939042.1  pleckstrin homology domain-containing family A member 1 isoform X1

      Conserved Domains (2) summary
      cd13270
      Location:1 → 117
      PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
      cd13271
      Location:195 → 306
      PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat

    19. XM_063267884.1 → XP_063123954.1  pleckstrin homology domain-containing family A member 1 isoform X5

      UniProtKB/TrEMBL
      A6IA45

    20. XM_063267881.1 → XP_063123951.1  pleckstrin homology domain-containing family A member 1 isoform X3

    21. XM_039083115.2 → XP_038939043.1  pleckstrin homology domain-containing family A member 1 isoform X1

      Conserved Domains (2) summary
      cd13270
      Location:1 → 117
      PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
      cd13271
      Location:195 → 306
      PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat

    22. XM_039083111.2 → XP_038939039.1  pleckstrin homology domain-containing family A member 1 isoform X1

      Conserved Domains (2) summary
      cd13270
      Location:1 → 117
      PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
      cd13271
      Location:195 → 306
      PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat

    23. XM_063267880.1 → XP_063123950.1  pleckstrin homology domain-containing family A member 1 isoform X3

    24. XM_063267879.1 → XP_063123949.1  pleckstrin homology domain-containing family A member 1 isoform X3

    25. XM_063267887.1 → XP_063123957.1  pleckstrin homology domain-containing family A member 1 isoform X8

    26. XM_063267883.1 → XP_063123953.1  pleckstrin homology domain-containing family A member 1 isoform X5

      UniProtKB/TrEMBL
      A6IA45

    27. XM_063267888.1 → XP_063123958.1  pleckstrin homology domain-containing family A member 1 isoform X10

    28. XM_063267896.1 → XP_063123966.1  pleckstrin homology domain-containing family A member 1 isoform X19

    29. XM_039083187.2 → XP_038939115.1  pleckstrin homology domain-containing family A member 1 isoform X18

      Conserved Domains (2) summary
      cd13271
      Location:113 → 224
      PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
      cl17171
      Location:1 → 35
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein Strain
    Heading Accession and Version

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