Med14 mediator complex subunit 14 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Med14provided by RGD
Official Full Name: mediator complex subunit 14provided by RGD
Primary source: RGD:1560170
See related: EnsemblRapid:ENSRNOG00000003792 AllianceGenome:RGD:1560170
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1560170
Summary: Predicted to enable transcription coactivator activity. Predicted to be involved in positive regulation of transcription initiation by RNA polymerase II. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II and somatic stem cell population maintenance. Predicted to be located in nucleus. Predicted to be part of core mediator complex and mediator complex. Orthologous to human MED14 (mediator complex subunit 14). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 137.9), Adrenal (RPKM 105.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq12

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (12709406..12800642)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (10036749..10127910)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (10964035..11082403)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH127471 (e-PCR)
- UniSTS:210781

Med14 (e-PCR), detects polymorphism
- UniSTS:547261

DXS7582 (e-PCR)
- UniSTS:36293

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coregulator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription initiation by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within somatic stem cell population maintenance	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of core mediator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of core mediator complex	ISO Inferred from Sequence Orthology more info
part_of mediator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mediator complex	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mediator of RNA polymerase II transcription subunit 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191727.2 → NP_001178656.1 mediator of RNA polymerase II transcription subunit 14

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

D4A020

Related

ENSRNOP00000063505.1, ENSRNOT00000066480.4

Conserved Domains (2) summary

pfam03957
Location:1052 → 1147

Jun; Jun-like transcription factor

pfam08638
Location:57 → 244

Med14; Mediator complex subunit MED14

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

12709406..12800642

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039099757.2 → XP_038955685.1 mediator of RNA polymerase II transcription subunit 14 isoform X1

UniProtKB/TrEMBL

A0A1W2Q643

Related

ENSRNOP00000076132.2, ENSRNOT00000093181.3

Conserved Domains (2) summary

PHA03307
Location:961 → 1160

PHA03307; transcriptional regulator ICP4; Provisional

pfam08638
Location:57 → 244

Med14; Mediator complex subunit MED14