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    Lpp LIM domain containing preferred translocation partner in lipoma [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288010, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lppprovided by RGD
    Official Full Name
    LIM domain containing preferred translocation partner in lipomaprovided by RGD
    Primary source
    RGD:1310535
    See related
    EnsemblRapid:ENSRNOG00000031669 AllianceGenome:RGD:1310535
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in cell-cell adhesion. Predicted to be located in cytosol. Predicted to be active in focal adhesion and stress fiber. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human LPP (LIM domain containing preferred translocation partner in lipoma). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Uterus (RPKM 204.6), Lung (RPKM 181.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lpp in Genome Data Viewer
    Location:
    11q23
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (89292060..89933973, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (75787326..76426646, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (79192603..79827858, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481022 Neighboring gene splicing factor 3A subunit 2, pseudogene 1 Neighboring gene uncharacterized LOC100910319 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene microRNA 28 Neighboring gene 40S ribosomal protein S3a-like Neighboring gene uncharacterized LOC108352383 Neighboring gene U7 small nuclear RNA Neighboring gene myosin light chain 6, pseudogene 5 Neighboring gene LIM domain containing preferred translocation partner in lipoma, opposite strand Neighboring gene uncharacterized LOC102553750

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Modulation of stretch-induced myocyte remodeling and gene expression by nitric oxide: a novel role for lipoma preferred partner in myofibrillogenesis. Hooper CL, et al. Am J Physiol Heart Circ Physiol, 2013 May 15. PMID 23504181, Free PMC Article
    2. Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites. Hoffert JD, et al. Proc Natl Acad Sci U S A, 2006 May 2. PMID 16641100, Free PMC Article
    3. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Kuo JC, et al. Nat Cell Biol, 2011 Apr. PMID 21423176, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LPP knockdown by small intefering RNA led to formation of alpha-actinin aggregates and Z bodies showing that myofibrillogenesis was impaired
      Title: Modulation of stretch-induced myocyte remodeling and gene expression by nitric oxide: a novel role for lipoma preferred partner in myofibrillogenesis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in stress fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lipoma-preferred partner homolog
    Names
    Lipoma-preferred-partner

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013864.1 → NP_001013886.1  lipoma-preferred partner homolog

      See identical proteins and their annotated locations for NP_001013886.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083627
      UniProtKB/Swiss-Prot
      Q5XI07
      UniProtKB/TrEMBL
      A0A8I6A5H9
      Related
      ENSRNOP00000090019.1, ENSRNOT00000113595.2
      Conserved Domains (3) summary
      cd09350
      Location:436 → 489
      LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      PHA03247
      Location:4 → 367
      PHA03247; large tegument protein UL36; Provisional
      cl02475
      Location:556 → 621
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      89292060..89933973 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270369.1 → XP_063126439.1  lipoma-preferred partner homolog isoform X3

    2. XM_039088098.2 → XP_038944026.1  lipoma-preferred partner homolog isoform X2

      Conserved Domains (4) summary
      cd09350
      Location:578 → 631
      LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      cd09436
      Location:698 → 763
      LIM3_TRIP6; The third LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      PHA03247
      Location:169 → 552
      PHA03247; large tegument protein UL36; Provisional
      cl02475
      Location:638 → 697
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    3. XM_039088097.2 → XP_038944025.1  lipoma-preferred partner homolog isoform X1

      Conserved Domains (5) summary
      cd09350
      Location:601 → 654
      LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      cd09436
      Location:721 → 786
      LIM3_TRIP6; The third LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      PHA03247
      Location:15 → 429
      PHA03247; large tegument protein UL36; Provisional
      PRK14086
      Location:347 → 534
      dnaA; chromosomal replication initiator protein DnaA
      cl02475
      Location:661 → 720
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    4. XM_039088099.2 → XP_038944027.1  lipoma-preferred partner homolog isoform X4

      UniProtKB/Swiss-Prot
      Q5XI07
      UniProtKB/TrEMBL
      A0A8I6A5H9
      Conserved Domains (3) summary
      cd09350
      Location:436 → 489
      LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      PHA03247
      Location:4 → 367
      PHA03247; large tegument protein UL36; Provisional
      cl02475
      Location:556 → 621
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    5. XM_017597911.3 → XP_017453400.1  lipoma-preferred partner homolog isoform X4

      UniProtKB/Swiss-Prot
      Q5XI07
      UniProtKB/TrEMBL
      A0A8I6A5H9
      Conserved Domains (3) summary
      cd09350
      Location:436 → 489
      LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      PHA03247
      Location:4 → 367
      PHA03247; large tegument protein UL36; Provisional
      cl02475
      Location:556 → 621
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    6. XM_017597913.3 → XP_017453402.1  lipoma-preferred partner homolog isoform X4

      UniProtKB/Swiss-Prot
      Q5XI07
      UniProtKB/TrEMBL
      A0A8I6A5H9
      Conserved Domains (3) summary
      cd09350
      Location:436 → 489
      LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      PHA03247
      Location:4 → 367
      PHA03247; large tegument protein UL36; Provisional
      cl02475
      Location:556 → 621
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    7. XM_017597910.3 → XP_017453399.1  lipoma-preferred partner homolog isoform X4

      UniProtKB/Swiss-Prot
      Q5XI07
      UniProtKB/TrEMBL
      A0A8I6A5H9
      Conserved Domains (3) summary
      cd09350
      Location:436 → 489
      LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      PHA03247
      Location:4 → 367
      PHA03247; large tegument protein UL36; Provisional
      cl02475
      Location:556 → 621
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    8. XM_006248505.5 → XP_006248567.1  lipoma-preferred partner homolog isoform X4

      See identical proteins and their annotated locations for XP_006248567.1

      UniProtKB/Swiss-Prot
      Q5XI07
      UniProtKB/TrEMBL
      A0A8I6A5H9
      Conserved Domains (3) summary
      cd09350
      Location:436 → 489
      LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      PHA03247
      Location:4 → 367
      PHA03247; large tegument protein UL36; Provisional
      cl02475
      Location:556 → 621
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    9. XM_017597912.3 → XP_017453401.1  lipoma-preferred partner homolog isoform X4

      UniProtKB/Swiss-Prot
      Q5XI07
      UniProtKB/TrEMBL
      A0A8I6A5H9
      Conserved Domains (3) summary
      cd09350
      Location:436 → 489
      LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      PHA03247
      Location:4 → 367
      PHA03247; large tegument protein UL36; Provisional
      cl02475
      Location:556 → 621
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    10. XM_039088102.2 → XP_038944030.1  lipoma-preferred partner homolog isoform X4

      UniProtKB/Swiss-Prot
      Q5XI07
      UniProtKB/TrEMBL
      A0A8I6A5H9
      Conserved Domains (3) summary
      cd09350
      Location:436 → 489
      LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      PHA03247
      Location:4 → 367
      PHA03247; large tegument protein UL36; Provisional
      cl02475
      Location:556 → 621
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    11. XM_063270371.1 → XP_063126441.1  lipoma-preferred partner homolog isoform X5

      UniProtKB/TrEMBL
      A0A8I6A5H9, A0A8L2QL16, A6JS03

    12. XM_017597915.3 → XP_017453404.1  lipoma-preferred partner homolog isoform X4

      UniProtKB/Swiss-Prot
      Q5XI07
      UniProtKB/TrEMBL
      A0A8I6A5H9
      Conserved Domains (3) summary
      cd09350
      Location:436 → 489
      LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      PHA03247
      Location:4 → 367
      PHA03247; large tegument protein UL36; Provisional
      cl02475
      Location:556 → 621
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    13. XM_063270372.1 → XP_063126442.1  lipoma-preferred partner homolog isoform X5

      UniProtKB/TrEMBL
      A0A8I6A5H9, A0A8L2QL16, A6JS03
      Related
      ENSRNOP00000042917.5, ENSRNOT00000044279.6

    14. XM_017597918.3 → XP_017453407.1  lipoma-preferred partner homolog isoform X4

      UniProtKB/Swiss-Prot
      Q5XI07
      UniProtKB/TrEMBL
      A0A8I6A5H9
      Conserved Domains (3) summary
      cd09350
      Location:436 → 489
      LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      PHA03247
      Location:4 → 367
      PHA03247; large tegument protein UL36; Provisional
      cl02475
      Location:556 → 621
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    15. XM_006248507.4 → XP_006248569.1  lipoma-preferred partner homolog isoform X6

      UniProtKB/TrEMBL
      A0A8I6A5H9
      Conserved Domains (2) summary
      cd09350
      Location:311 → 364
      LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      cl02475
      Location:431 → 496
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    16. XM_063270373.1 → XP_063126443.1  lipoma-preferred partner homolog isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZVW3, A0A8I6A5H9
      Related
      ENSRNOP00000083451.1, ENSRNOT00000096354.2

    17. XM_039088103.2 → XP_038944031.1  lipoma-preferred partner homolog isoform X8

      UniProtKB/TrEMBL
      A0A8I6A5H9
      Conserved Domains (3) summary
      cd09350
      Location:272 → 325
      LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      PRK14086
      Location:18 → 205
      dnaA; chromosomal replication initiator protein DnaA
      cl02475
      Location:392 → 457
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XI07.1 GenPept UniProtKB/Swiss-Prot:Q5XI07

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