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    Faf2 Fas associated factor family member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291000, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Faf2provided by RGD
    Official Full Name
    Fas associated factor family member 2provided by RGD
    Primary source
    RGD:1306577
    See related
    EnsemblRapid:ENSRNOG00000017607 AllianceGenome:RGD:1306577
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ubxd8; RGD1306577; 2210404d11rik
    Summary
    Predicted to enable several functions, including enzyme binding activity; lipase inhibitor activity; and ubiquitin binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process; retrograde protein transport, ER to cytosol; and stress granule disassembly. Predicted to act upstream of or within lipid droplet organization. Predicted to be located in lipid droplet. Predicted to be part of VCP-NPL4-UFD1 AAA ATPase complex. Predicted to be active in endoplasmic reticulum. Orthologous to human FAF2 (Fas associated factor family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 89.0), Kidney (RPKM 86.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Faf2 in Genome Data Viewer
    Location:
    17p14
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (9952329..9994596, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (9947211..9989474, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (10485650..10527886, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene cadherin-related family member 2 Neighboring gene ring finger protein 44 Neighboring gene clathrin, light chain B Neighboring gene HIG1 hypoxia inducible domain family, member 2A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Pathogenic mutation of UBQLN2 impairs its interaction with UBXD8 and disrupts endoplasmic reticulum-associated protein degradation. Xia Y, et al. J Neurochem, 2014 Apr. PMID 24215460
    2. Spatial regulation of UBXD8 and p97/VCP controls ATGL-mediated lipid droplet turnover. Olzmann JA, et al. Proc Natl Acad Sci U S A, 2013 Jan 22. PMID 23297223, Free PMC Article
    3. Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling. Osorio FG, et al. Nat Med, 2016 Jan. PMID 26692333
    4. Identification of major proteins in the lipid droplet-enriched fraction isolated from the human hepatocyte cell line HuH7. Fujimoto Y, et al. Biochim Biophys Acta, 2004 Feb 2. PMID 14741744
    5. Identification of ERAD components essential for dislocation of the null Hong Kong variant of α-1-antitrypsin (NHK). Zhong Y, et al. Biochem Biophys Res Commun, 2015 Mar 6. PMID 25660456

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108962

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables lipase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lipase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-macromolecule adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-macromolecule adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ERAD pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lipid droplet organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid droplet organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to unfolded protein IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde protein transport, ER to cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde protein transport, ER to cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stress granule disassembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in stress granule disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stress granule disassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of VCP-NPL4-UFD1 AAA ATPase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of VCP-NPL4-UFD1 AAA ATPase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    FAS-associated factor 2
    Names
    UBX domain containing 8
    UBX domain-containing protein 8
    protein expressed in T-cells and eosinophils in atopic dermatitis

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017445.2 → NP_001017445.1  FAS-associated factor 2 isoform 2

      See identical proteins and their annotated locations for NP_001017445.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/Swiss-Prot
      Q5BK32
      UniProtKB/TrEMBL
      A0A0G2JTA0
      Related
      ENSRNOP00000063246.2, ENSRNOT00000064477.4
      Conserved Domains (2) summary
      cd02991
      Location:55 → 170
      UAS_ETEA; UAS family, ETEA subfamily; composed of proteins similar to human ETEA protein, the translation product of a highly expressed gene in the T-cells and eosinophils of atopic dermatitis patients compared with those of normal individuals. ETEA shows homology ...
      cl00155
      Location:263 → 343
      UBQ; Ubiquitin-like proteins

    2. NM_001399396.1 → NP_001386325.1  FAS-associated factor 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A0G2JTA0, A6KAX9
      Related
      ENSRNOP00000068627.3, ENSRNOT00000091837.3
      Conserved Domains (3) summary
      cd02991
      Location:154 → 269
      UAS_ETEA; UAS family, ETEA subfamily; composed of proteins similar to human ETEA protein, the translation product of a highly expressed gene in the T-cells and eosinophils of atopic dermatitis patients compared with those of normal individuals. ETEA shows homology ...
      cd14414
      Location:15 → 52
      UBA_FAF2; UBA-like TAP-C domain found in FAS-associated factor 2 (FAF2) and similar proteins
      cd16120
      Location:362 → 441
      UBX_UBXN3B; Ubiquitin regulatory domain X (UBX) found in FAS associated factor 2 (FAF2, also known as UBXN3B) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      9952329..9994596 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008771488.4 → XP_008769710.1  FAS-associated factor 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZPX1
      Related
      ENSRNOP00000080533.1, ENSRNOT00000095037.2
      Conserved Domains (3) summary
      cd02991
      Location:89 → 197
      UAS_ETEA; UAS family, ETEA subfamily; composed of proteins similar to human ETEA protein, the translation product of a highly expressed gene in the T-cells and eosinophils of atopic dermatitis patients compared with those of normal individuals. ETEA shows homology ...
      cl00155
      Location:290 → 370
      UBQ; Ubiquitin-like proteins
      cl21463
      Location:15 → 52
      UBA_like_SF; UBA domain-like superfamily

    2. XM_063276148.1 → XP_063132218.1  FAS-associated factor 2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JTA0, A0A8I6A8N6
      Related
      ENSRNOP00000086396.1, ENSRNOT00000096763.2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BK32.1 GenPept UniProtKB/Swiss-Prot:Q5BK32

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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