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    Ttpal alpha tocopherol transfer protein like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296349, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ttpalprovided by RGD
    Official Full Name
    alpha tocopherol transfer protein likeprovided by RGD
    Primary source
    RGD:1305754
    See related
    EnsemblRapid:ENSRNOG00000009076 AllianceGenome:RGD:1305754
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305754
    Summary
    Predicted to enable phosphatidylinositol bisphosphate binding activity. Orthologous to human TTPAL (alpha tocopherol transfer protein like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 142.7), Thymus (RPKM 114.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ttpal in Genome Data Viewer
    Location:
    3q42
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (172697683..172715973)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (152278246..152296550)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (159995013..160015314)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101780 Neighboring gene hepatocyte nuclear factor 4, alpha Neighboring gene ATP synthase membrane subunit c locus 2, pseudogene 4 Neighboring gene serine incorporator 3 Neighboring gene cAMP-dependent protein kinase inhibitor gamma

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylinositol bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    alpha-tocopherol transfer protein-like
    Names
    tocopherol (alpha) transfer protein-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106537.2 → NP_001100007.1  alpha-tocopherol transfer protein-like

      See identical proteins and their annotated locations for NP_001100007.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6JX39, D3ZGM8
      Related
      ENSRNOP00000012607.5, ENSRNOT00000012606.7
      Conserved Domains (2) summary
      smart01100
      Location:57 → 103
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      cd00170
      Location:122 → 278
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

    2. NM_001430201.1 → NP_001417130.1  alpha-tocopherol transfer protein-like

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6JX39, D3ZGM8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      172697683..172715973
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006235529.5 → XP_006235591.1  alpha-tocopherol transfer protein-like isoform X1

      Conserved Domains (2) summary
      smart01100
      Location:57 → 103
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      cd00170
      Location:122 → 278
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
    Nucleotide Protein Strain
    Heading Accession and Version

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