Flna filamin A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Flnaprovided by RGD
Official Full Name: filamin Aprovided by RGD
Primary source: RGD:1560614
See related: EnsemblRapid:ENSRNOG00000054890 AllianceGenome:RGD:1560614
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1560614
Summary: Enables SMAD binding activity. Involved in several processes, including brain development; establishment of Sertoli cell barrier; and mRNA transcription by RNA polymerase II. Located in several cellular components, including cytoskeleton; dendrite; and neuronal cell body. Is active in glutamatergic synapse and postsynapse. Used to study periventricular nodular heterotopia. Human ortholog(s) of this gene implicated in X-linked chronic idiopathic intestinal pseudo-obstruction; bone development disease (multiple); heart valve disease (multiple); periventricular nodular heterotopia; and terminal osseous dysplasia. Orthologous to human FLNA (filamin A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Uterus (RPKM 2133.5), Lung (RPKM 1473.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq37

Exon count:: 48

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (157159051..157185559, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (152007758..152034266, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (156460785..156487245)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Filamin A facilitates NLRP3 inflammasome activation during arsenic-induced nonalcoholic steatohepatitis.
Title: Filamin A facilitates NLRP3 inflammasome activation during arsenic-induced nonalcoholic steatohepatitis.
Flna is involved in SST2 stabilization and signaling in tumoral somatotrophs
Title: Filamin A (FLNA) plays an essential role in somatostatin receptor 2 (SST2) signaling and stabilization after agonist stimulation in human and rat somatotroph tumor cells.
a major function of FLNa in modulating ion channel abundance and membrane trafficking in neurons, thereby shaping their biophysical properties and function.
Title: Filamin A promotes dynamin-dependent internalization of hyperpolarization-activated cyclic nucleotide-gated type 1 (HCN1) channels and restricts Ih in hippocampal neurons.
filamin A participates in blood-testis barrier assembly by regulating protein recruitment during postnatal development in the rat testis.
Title: Filamin A is a regulator of blood-testis barrier assembly during postnatal development in the rat testis.
we characterize in detail the neuroanatomical distribution and subcellular localization of FLNa in the mature rat brain
Title: Distinct regional and subcellular localization of the actin-binding protein filamin A in the mature rat brain.
data highlight the critical role of FLNA in radial glia organization and function for neurogenesis and migration and also provide insight into the molecular pathogenesis of human periventricular nodular heterotopia
Title: A glial origin for periventricular nodular heterotopia caused by impaired expression of Filamin-A.
Ureaplasma parvum infection alters filamin A dynamics in host cells.
Title: Ureaplasma parvum infection alters filamin A dynamics in host cells.
Isoproterenol activation of ACs promoted filamin phosphorylation, whereas thrombin inhibition of AC6 reduced filamin phosphorylation within the membrane fraction
Title: Filamin A is a phosphorylation target of membrane but not cytosolic adenylyl cyclase activity.
Insulin-like growth factor-binding protein-5-induced laminin gamma1 transcription requires filamin A.
Title: Insulin-like growth factor-binding protein-5-induced laminin gamma1 transcription requires filamin A.
High amplitude forces delivered through integrins can promote apoptosis in a proportion of cells and that filamin A confers mechanoprotection by preventing membrane depolarization.
Title: Cell death and mechanoprotection by filamin a in connective tissues after challenge by applied tensile forces.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ECD01291 (e-PCR)
- UniSTS:282397

ECD00293 (e-PCR)
- UniSTS:281406

REN89262 (e-PCR)
- UniSTS:414060

REN89263 (e-PCR)
- UniSTS:414061

RH134438 (e-PCR)
- UniSTS:217718

REN89288 (e-PCR)
- UniSTS:414086

REN89289 (e-PCR)
- UniSTS:414087

REN89318 (e-PCR)
- UniSTS:414116

REN89349 (e-PCR)
- UniSTS:414147

ECD02527 (e-PCR)
- UniSTS:283622

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables Fc-gamma receptor I complex binding	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor binding	ISO Inferred from Sequence Orthology more info
enables GTPase binding	ISO Inferred from Sequence Orthology more info
enables SMAD binding	IPI Inferred from Physical Interaction more info	PubMed
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables potassium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase C binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin crosslink formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting dopamine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in blood vessel remodeling	ISO Inferred from Sequence Orthology more info
involved_in cell-cell junction organization	ISO Inferred from Sequence Orthology more info
involved_in cerebral cortex development	IEP Inferred from Expression Pattern more info	PubMed
involved_in cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in cytoplasmic sequestering of protein	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within early endosome to late endosome transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in establishment of Sertoli cell barrier	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of protein localization	ISO Inferred from Sequence Orthology more info
involved_in formation of radial glial scaffolds	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in mRNA transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitotic spindle assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase I	ISO Inferred from Sequence Orthology more info
involved_in platelet aggregation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of actin filament bundle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axon regeneration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neural precursor cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in protein localization to bicellular tight junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to cell surface	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin filament bundle assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane repolarization during cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in semaphorin-plexin signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in synapse organization	ISO Inferred from Sequence Orthology more info
involved_in tubulin deacetylation	ISO Inferred from Sequence Orthology more info
involved_in wound healing, spreading of cells	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Myb complex	ISO Inferred from Sequence Orthology more info
located_in Z disc	ISO Inferred from Sequence Orthology more info
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in actin filament	IDA Inferred from Direct Assay more info	PubMed
located_in actin filament bundle	ISO Inferred from Sequence Orthology more info
located_in apical dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in axonal growth cone	ISO Inferred from Sequence Orthology more info
located_in brush border	ISO Inferred from Sequence Orthology more info
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cortical cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendritic shaft	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in podosome	IEA Inferred from Electronic Annotation more info
located_in podosome	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: filamin-A

Names: Endothelial actin-binding protein 280); actin binding protein 280; filamin A, alpha; filamin, alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001134599.1 → NP_001128071.1 filamin-A isoform 2

See identical proteins and their annotated locations for NP_001128071.1

Status: PROVISIONAL

Source sequence(s)

CH474099

UniProtKB/TrEMBL

A0A0G2JYL6, A6KRS3, A6KRS4, C0JPT7

Related

ENSRNOP00000070703.1, ENSRNOT00000079889.3

Conserved Domains (4) summary

smart00033
Location:172 → 264

CH; Calponin homology domain

smart00557
Location:2039 → 2128

IG_FLMN; Filamin-type immunoglobulin domains

cd00014
Location:44 → 148

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

pfam00630
Location:1858 → 1941

Filamin; Filamin/ABP280 repeat
NM_001433951.1 → NP_001420880.1 filamin-A isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

A0A8I5ZV49, A6KRS4
NM_001433952.1 → NP_001420881.1 filamin-A isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

A0A0G2JYL6, A6KRS3, A6KRS4, C0JPT7
NM_001433953.1 → NP_001420882.1 filamin-A isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

A0A0G2JYL6, A6KRS3, A6KRS4, C0JPT7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

157159051..157185559 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006229570.5 → XP_006229632.1 filamin-A isoform X2

Conserved Domains (4) summary

smart00033
Location:172 → 264

CH; Calponin homology domain

smart00557
Location:2039 → 2128

IG_FLMN; Filamin-type immunoglobulin domains

cd00014
Location:44 → 148

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

pfam00630
Location:1858 → 1941

Filamin; Filamin/ABP280 repeat
XM_006229569.5 → XP_006229631.1 filamin-A isoform X1

Conserved Domains (3) summary

smart00557
Location:2047 → 2136

IG_FLMN; Filamin-type immunoglobulin domains

cd21308
Location:25 → 153

CH_FLNA_rpt1; first calponin homology (CH) domain found in filamin-A (FLN-A) and similar proteins

cd21312
Location:156 → 269

CH_FLNA_rpt2; second calponin homology (CH) domain found in filamin-A (FLN-A) and similar proteins
XM_063279840.1 → XP_063135910.1 filamin-A isoform X2
XM_063279839.1 → XP_063135909.1 filamin-A isoform X1

UniProtKB/TrEMBL

A0A8I5ZV49, A6KRS4

Related

ENSRNOP00000082035.1, ENSRNOT00000109154.2