Tmprss11c transmembrane protease, serine 11C [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tmprss11cprovided by RGD
Official Full Name: transmembrane protease, serine 11Cprovided by RGD
Primary source: RGD:1302967
See related: EnsemblRapid:ENSRNOG00000033910 AllianceGenome:RGD:1302967
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hatl3
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in self proteolysis. Predicted to be located in dendrite; perikaryon; and plasma membrane. Orthologous to human TMPRSS11CP (transmembrane serine protease 11C, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 5.2), Adrenal (RPKM 1.0) and 2 other tissues See more
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Genomic context

Location:: 14p21

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (22136865..22195312)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (21782076..21840517)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (23405717..23461384)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in self proteolysis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transmembrane protease, serine 11C

Names: airway trypsin-like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003979.2 → NP_001003979.1 transmembrane protease, serine 11C isoform 2

See identical proteins and their annotated locations for NP_001003979.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/TrEMBL

F7FFT3, Q6IE15

Related

ENSRNOP00000035600.2, ENSRNOT00000029805.4

Conserved Domains (3) summary

smart00020
Location:186 → 412

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:187 → 415

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam01390
Location:62 → 157

SEA; SEA domain
NM_001412525.1 → NP_001399454.1 transmembrane protease, serine 11C isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/TrEMBL

A0A8I5ZM18

Related

ENSRNOP00000079095.1, ENSRNOT00000094058.2