Oxct1 3-oxoacid CoA transferase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Oxct1provided by RGD
Full Name: 3-oxoacid CoA transferase 1provided by RGD
Primary source: RGD:1584008
See related: EnsemblRapid:ENSRNOG00000043094 AllianceGenome:RGD:1584008
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: SCOT
Summary: Enables identical protein binding activity and succinyl-CoA:3-oxo-acid CoA-transferase activity. Involved in several processes, including cellular ketone body metabolic process; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and response to activity. Predicted to be active in mitochondrion. Biomarker of obesity and type 2 diabetes mellitus. Orthologous to human OXCT1 (3-oxoacid CoA-transferase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 3677.2), Kidney (RPKM 1613.1) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q16

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (54963964..55112303)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (53236370..53384715)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (53859738..54007733)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

mRNAs of SCOT and ATP citrate lyase were decreased 55% and 58% and enzyme activities were decreased >70% in pancreatic islets of the GK rat, a model of type 2 diabetes.
Title: Lower succinyl-CoA:3-ketoacid-CoA transferase (SCOT) and ATP citrate lyase in pancreatic islets of a rat model of type 2 diabetes: knockdown of SCOT inhibits insulin release in rat insulinoma cells.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH136940 (e-PCR)
- UniSTS:219029

AA819087 (e-PCR)
- UniSTS:243438

BF416594 (e-PCR)
- UniSTS:260849

AU049976 (e-PCR)
- UniSTS:146418

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables CoA-transferase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables succinyl-CoA:3-oxo-acid CoA-transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables succinyl-CoA:3-oxo-acid CoA-transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables succinyl-CoA:3-oxo-acid CoA-transferase activity	IEA Inferred from Electronic Annotation more info
enables succinyl-CoA:3-oxo-acid CoA-transferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adipose tissue development	IEP Inferred from Expression Pattern more info	PubMed
involved_in heart development	IEP Inferred from Expression Pattern more info	PubMed
involved_in ketone body catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ketone body catabolic process	ISO Inferred from Sequence Orthology more info
involved_in ketone body metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ketone catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ketone catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial

Names: scot-S; somatic-type succinyl-CoA:3-oxoacid CoA-transferase; succinyl-CoA:3-ketoacid CoA transferase; succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial-like; succinyl-CoA:3-oxoacid CoA transferase

NP_001121052.1

EC 2.8.3.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001127580.1 → NP_001121052.1 succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial precursor

See identical proteins and their annotated locations for NP_001121052.1

Status: PROVISIONAL

Source sequence(s)

BC166478

UniProtKB/Swiss-Prot

B2GV06

UniProtKB/TrEMBL

A0A8L2UNL5

Related

ENSRNOP00000090363.2, ENSRNOT00000107045.2

Conserved Domains (3) summary

COG1788
Location:41 → 274

AtoD; Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid transport and metabolism]

COG4670
Location:48 → 517

YdiF; Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid transport and metabolism]

cl00339
Location:300 → 508

SugarP_isomerase; SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ...