Abcd2 ATP binding cassette subfamily D member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Abcd2provided by RGD
Official Full Name: ATP binding cassette subfamily D member 2provided by RGD
Primary source: RGD:69244
See related: EnsemblRapid:ENSRNOG00000015538 AllianceGenome:RGD:69244
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ALDR
Summary: Enables protein heterodimerization activity and protein homodimerization activity. Involved in very long-chain fatty acid catabolic process. Located in peroxisomal membrane. Orthologous to human ABCD2 (ATP binding cassette subfamily D member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 77.6), Brain (RPKM 74.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q35

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (124142597..124191202, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (122263034..122311642, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (132294564..132343169, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ABCD1 and its homolog ABCD2 exist mainly as homotetramers in the peroxisomal membrane
Title: Peroxisomal ATP-binding cassette transporters form mainly tetramers.
Substrate specificity overlap and interaction between adrenoleukodystrophy protein (ALDP/ABCD1) and adrenoleukodystrophy-related protein (ALDRP/ABCD2).
Title: Substrate specificity overlap and interaction between adrenoleukodystrophy protein (ALDP/ABCD1) and adrenoleukodystrophy-related protein (ALDRP/ABCD2).
NRH2 utilizes intracellular mechanisms not only to regulate nerve growth factor binding to tropomyosin-related kinase receptor A (TrkA), but also to specifically modulate TrkA receptor signaling.
Title: Neurotrophin receptor homolog-2 regulates nerve growth factor signaling.
in vitro and in vivo effects of DHEA on the expression of peroxisomal ABC transporters, including Abcd2
Title: Dehydroepiandrosterone up-regulates the Adrenoleukodystrophy-related gene (ABCD2) independently of PPARalpha in rodents.
The generated stable cell lines express negligible levels of endogenous ALDRP and doxycycline dosage-dependent levels of normal or mutated ALDRP.
Title: A novel cell model to study the function of the adrenoleukodystrophy-related protein.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE109878 (e-PCR)
- UniSTS:248369

BE116218 (e-PCR)
- UniSTS:248454

RH144115 (e-PCR)
- UniSTS:233361

D7Wox48 (e-PCR)
- UniSTS:518873

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase-coupled transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables ATPase-coupled transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables fatty acyl-CoA hydrolase activity	ISO Inferred from Sequence Orthology more info
enables fatty acyl-CoA hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info
enables long-chain fatty acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in fatty acid beta-oxidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid beta-oxidation	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid import into peroxisome	IBA Inferred from Biological aspect of Ancestor more info
involved_in myelin maintenance	ISO Inferred from Sequence Orthology more info
involved_in myelin maintenance	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cytokine production involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytokine production involved in inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of reactive oxygen species biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of reactive oxygen species biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron projection maintenance	ISO Inferred from Sequence Orthology more info
involved_in neuron projection maintenance	ISS Inferred from Sequence or Structural Similarity more info
involved_in peroxisome organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of fatty acid beta-oxidation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fatty acid beta-oxidation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of unsaturated fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of unsaturated fatty acid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in very long-chain fatty acid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in very long-chain fatty acid catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in very long-chain fatty acid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in very long-chain fatty acid catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in very long-chain fatty acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in very long-chain fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in very long-chain fatty acid metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in peroxisomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ATP-binding cassette sub-family D member 2

Names: ATP-binding cassette, sub-family D (ALD), member 2; ATP-binding cassette, subfamily D (ALD), member 2; adrenoleukodystrophy-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_033352.2 → NP_203503.2 ATP-binding cassette sub-family D member 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

G3V7Z6, Q9QY44

Related

ENSRNOP00000021064.1, ENSRNOT00000021064.4

Conserved Domains (1) summary

TIGR00954
Location:74 → 686

3a01203; Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein