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    Zswim2 zinc finger, SWIM-type containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296455, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Zswim2provided by RGD
    Official Full Name
    zinc finger, SWIM-type containing 2provided by RGD
    Primary source
    RGD:1311373
    See related
    EnsemblRapid:ENSRNOG00000032579 AllianceGenome:RGD:1311373
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein polyubiquitination. Predicted to act upstream of or within positive regulation of extrinsic apoptotic signaling pathway via death domain receptors. Orthologous to human ZSWIM2 (zinc finger SWIM-type containing 2). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Restricted expression toward (RPKM 173.6) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zswim2 in Genome Data Viewer
    Location:
    3q24
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (89401887..89422308, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (68993422..69015441, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (71274341..71295641, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 171, member B Neighboring gene large ribosomal subunit protein eL8-like Neighboring gene transfer RNA proline (anticodon AGG) 5 Neighboring gene uncharacterized LOC134486292

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MEX is a testis-specific E3 ubiquitin ligase that promotes death receptor-induced apoptosis. Nishito Y, et al. Biochem J, 2006 Jun 15. PMID 16522193, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase ZSWIM2
    Names
    zinc finger SWIM domain-containing protein 2
    zinc finger, SWIM domain containing 2
    NP_001011960.1
    XP_038960590.1
    XP_063139488.1
    XP_063139489.1
    XP_063139490.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011960.2 → NP_001011960.1  E3 ubiquitin-protein ligase ZSWIM2 isoform 1

      See identical proteins and their annotated locations for NP_001011960.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A0G2JZ24, A0A8J8XBL1, E9PTV6, Q68FQ1
      Related
      ENSRNOP00000070884.2, ENSRNOT00000083015.3
      Conserved Domains (3) summary
      pfam04434
      Location:54 → 86
      SWIM; SWIM zinc finger
      pfam13639
      Location:343 → 386
      zf-RING_2; Ring finger domain
      cl00295
      Location:233 → 276
      ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...

    2. NM_001430311.1 → NP_001417240.1  E3 ubiquitin-protein ligase ZSWIM2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    3. NM_001430312.1 → NP_001417241.1  E3 ubiquitin-protein ligase ZSWIM2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    RNA

    1. NR_190887.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      89401887..89422308 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104662.2 → XP_038960590.1  E3 ubiquitin-protein ligase ZSWIM2 isoform X3

      Conserved Domains (3) summary
      pfam04434
      Location:54 → 86
      SWIM; SWIM zinc finger
      cd16494
      Location:144 → 202
      RING-CH-C4HC3_ZSWM2; RING-CH finger, H2 subclass (C4HC3-type), found in zinc finger SWIM domain-containing protein 2 (ZSWIM2) and similar proteins
      cl00295
      Location:233 → 276
      ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...

    2. XM_063283419.1 → XP_063139489.1  E3 ubiquitin-protein ligase ZSWIM2 isoform X2

    3. XM_063283418.1 → XP_063139488.1  E3 ubiquitin-protein ligase ZSWIM2 isoform X1

    4. XM_063283420.1 → XP_063139490.1  E3 ubiquitin-protein ligase ZSWIM2 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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