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    Cdt1 chromatin licensing and DNA replication factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292071, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cdt1provided by RGD
    Official Full Name
    chromatin licensing and DNA replication factor 1provided by RGD
    Primary source
    RGD:1309211
    See related
    EnsemblRapid:ENSRNOG00000013970 AllianceGenome:RGD:1309211
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ris2
    Summary
    Predicted to enable DNA binding activity; DNA polymerase binding activity; and chromatin binding activity. Predicted to be involved in several processes, including DNA replication checkpoint signaling; attachment of mitotic spindle microtubules to kinetochore; and regulation of DNA-templated DNA replication. Predicted to act upstream of or within regulation of nuclear cell cycle DNA replication. Predicted to be located in kinetochore and nuclear body. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 4. Orthologous to human CDT1 (chromatin licensing and DNA replication factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 44.5), Spleen (RPKM 40.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cdt1 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (67529249..67534195)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (50620713..50625659)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (55381565..55386511)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene cytosolic thiouridylase subunit 2 Neighboring gene piezo-type mechanosensitive ion channel component 1 Neighboring gene uncharacterized LOC103694354 Neighboring gene adenine phosphoribosyl transferase Neighboring gene galactosamine (N-acetyl)-6-sulfatase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Oncogenic potential of the DNA replication licensing protein CDT1. Arentson E, et al. Oncogene, 2002 Feb 14. PMID 11850834
    2. The regulated association of Cdt1 with minichromosome maintenance proteins and Cdc6 in mammalian cells. Cook JG, et al. J Biol Chem, 2004 Mar 5. PMID 14672932
    3. Mouse geminin inhibits not only Cdt1-MCM6 interactions but also a novel intrinsic Cdt1 DNA binding activity. Yanagi K, et al. J Biol Chem, 2002 Oct 25. PMID 12192004
    4. Recruitment of the human Cdt1 replication licensing protein by the loop domain of Hec1 is required for stable kinetochore-microtubule attachment. Varma D, et al. Nat Cell Biol, 2012 May 13. PMID 22581055, Free PMC Article
    5. Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding. Sugimoto N, et al. J Biol Chem, 2004 May 7. PMID 14993212

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA polymerase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA replication preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication preinitiation complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in attachment of mitotic spindle microtubules to kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA-templated DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated DNA replication initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of nuclear cell cycle DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to sorbitol ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA replication factor Cdt1
    Names
    retroviral integration site 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106192.1 → NP_001099662.1  DNA replication factor Cdt1

      See identical proteins and their annotated locations for NP_001099662.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473972
      UniProtKB/TrEMBL
      A6IZS7, D3ZKD4
      Related
      ENSRNOP00000018923.4, ENSRNOT00000018923.7
      Conserved Domains (2) summary
      cd08674
      Location:180 → 363
      Cdt1_m; The middle winged helix fold of replication licensing factor Cdt1 binds geminin to inhibit binding of the MCM complex to origins of replication and DNA
      cd08767
      Location:426 → 548
      Cdt1_c; The C-terminal fold of replication licensing factor Cdt1 is essential for Cdt1 activity and directly interacts with MCM2-7 helicase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      67529249..67534195
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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