Fam162a family with sequence similarity 162, member A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fam162aprovided by RGD
Official Full Name: family with sequence similarity 162, member Aprovided by RGD
Primary source: RGD:1590883
See related: EnsemblRapid:ENSRNOG00000002255 AllianceGenome:RGD:1590883
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; cellular response to hypoxia; and positive regulation of release of cytochrome c from mitochondria. Predicted to be located in cytosol. Predicted to be active in mitochondrion. Orthologous to human FAM162A (family with sequence similarity 162 member A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 1534.1), Muscle (RPKM 486.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q22

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (78186260..78215186)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (64680978..64709865)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (67618683..67646253)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BI283380 (e-PCR)
- UniSTS:243527

RH139177 (e-PCR)
- UniSTS:221263

AW531837 (e-PCR)
- UniSTS:245130

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in cellular response to hypoxia	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in neuron apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cysteine-type endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of release of cytochrome c from mitochondria	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of release of cytochrome c from mitochondria	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein FAM162A

Names: E2-induced gene 5 protein homolog; growth and transformation-dependent protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399276.2 → NP_001386205.1 protein FAM162A

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/Swiss-Prot

Q4QQV3

UniProtKB/TrEMBL

A0A8I6AP17, A6IRE2

Related

ENSRNOP00000096204.2, ENSRNOT00000099640.2

Conserved Domains (1) summary

pfam06388
Location:16 → 134

DUF1075; Protein of unknown function (DUF1075)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

78186260..78215186

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063270641.1 → XP_063126711.1 protein FAM162A isoform X1

UniProtKB/TrEMBL

A0A8I5ZR27

Related

ENSRNOP00000081032.1, ENSRNOT00000116350.2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001029903.1: Suppressed sequence

Description

NM_001029903.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.