Crat carnitine O-acetyltransferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cratprovided by RGD
Official Full Name: carnitine O-acetyltransferaseprovided by RGD
Primary source: RGD:1303031
See related: EnsemblRapid:ENSRNOG00000018145 AllianceGenome:RGD:1303031
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables carnitine O-acetyltransferase activity. Involved in fatty acid metabolic process. Predicted to be located in mitochondrion. Predicted to be active in peroxisome. Human ortholog(s) of this gene implicated in neurodegeneration with brain iron accumulation. Orthologous to human CRAT (carnitine O-acetyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 992.1), Muscle (RPKM 887.3) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3p12

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (34073504..34087099, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (13675684..13689282, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (8967984..8981959, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lipid-induced antagonism of CrAT might contribute to decreased PDH activity and glucose disposal in the context of obesity and diabetes.
Title: Obesity and lipid stress inhibit carnitine acetyltransferase activity.
this assay can be used to measure carnitine acetyltransferase activity in the same samples, and assays comparing choline O-acetyltransferase and CrAT show that carnitine acetyltransferase is highly active in neuronal tissues and in neuronal cell cultures
Title: Chromatographic separation of reaction products from the choline acetyltransferase and carnitine acetyltransferase assay: differential ChAT and CrAT activity in brain extracts from Alzheimer's disease versus controls.
The predicted full length cDNA sequence of the porcine CRAT gene was characterised and a new 5' variant for dog, rat and mouse was proposed.
Title: The carnitine acetyltransferase gene (CRAT): a characterization of porcine transcripts with insights into the 5'-end variants of mammalian transcripts and their possible sub-cellular localization.
by performing two amino acid replacements a carnitine acetyltransferase can be converted into a pseudo carnitine palmitoyltransferase in terms of substrate specificity
Title: Mutagenesis of specific amino acids converts carnitine acetyltransferase into carnitine palmitoyltransferase.
show for the first time that a single amino acid is able to determine the substrate specificity of carnitine acetyltransferase (CrAT)
Title: Redesign of carnitine acetyltransferase specificity by protein engineering.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables O-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyl-CoA oxidase activity	IEA Inferred from Electronic Annotation more info
enables acyl-CoA oxidase activity	ISO Inferred from Sequence Orthology more info
enables acyl-CoA oxidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables carnitine O-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables carnitine O-acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables carnitine O-acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables carnitine O-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables carnitine O-octanoyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carnitine metabolic process, CoA-linked	IBA Inferred from Biological aspect of Ancestor more info
involved_in carnitine metabolic process, CoA-linked	IEA Inferred from Electronic Annotation more info
involved_in carnitine metabolic process, CoA-linked	ISO Inferred from Sequence Orthology more info
involved_in carnitine metabolic process, CoA-linked	ISS Inferred from Sequence or Structural Similarity more info
involved_in fatty acid beta-oxidation using acyl-CoA oxidase	IEA Inferred from Electronic Annotation more info
involved_in fatty acid beta-oxidation using acyl-CoA oxidase	ISO Inferred from Sequence Orthology more info
involved_in fatty acid beta-oxidation using acyl-CoA oxidase	ISS Inferred from Sequence or Structural Similarity more info
involved_in fatty acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in medium-chain fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in medium-chain fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in medium-chain fatty acid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in short-chain fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in short-chain fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in short-chain fatty acid metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IEA Inferred from Electronic Annotation more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info
located_in peroxisome	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: carnitine O-acetyltransferase

Names: CAT; carnitine acetylase; carnitine acetyltransferase

NP_001004085.1

EC 2.3.1.137

EC 2.3.1.7

XP_063140021.1

EC 2.3.1.137

EC 2.3.1.7

XP_063140022.1

EC 2.3.1.137

EC 2.3.1.7

XP_063140023.1

EC 2.3.1.137

EC 2.3.1.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.