U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Dhx57 DExH-box helicase 57 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366532, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Dhx57provided by RGD
    Official Full Name
    DExH-box helicase 57provided by RGD
    Primary source
    RGD:1310340
    See related
    EnsemblRapid:ENSRNOG00000054272 AllianceGenome:RGD:1310340
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA binding activity and helicase activity. Orthologous to human DHX57 (DExH-box helicase 57). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 112.9), Adrenal (RPKM 97.5) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Dhx57 in Genome Data Viewer
    Location:
    6q12
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (20474889..20528556)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (14725305..14776321)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (2921340..2961397, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 33 Neighboring gene uncharacterized LOC134479101 Neighboring gene eukaryotic translation initiation factor 4A2, pseudogene 2 Neighboring gene MORN repeat containing 2 Neighboring gene gem (nuclear organelle) associated protein 6 Neighboring gene tetratricopeptide repeat domain 39D

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    2. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    putative ATP-dependent RNA helicase DHX57
    Names
    DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
    DEAH-box helicase 57
    NP_001178836.1
    XP_038968537.1
    XP_038968538.1
    XP_038968541.1
    XP_038968543.2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191907.2 → NP_001178836.1  putative ATP-dependent RNA helicase DHX57

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A0G2JZH9
      Conserved Domains (4) summary
      COG1643
      Location:504 → 1301
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      cd14317
      Location:184 → 221
      UBA_DHX57; UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins
      pfam05773
      Location:249 → 422
      RWD; RWD domain
      pfam18345
      Location:308 → 326
      zf_CCCH_4; Zinc finger domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      20474889..20528556
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112615.2 → XP_038968543.2  putative ATP-dependent RNA helicase DHX57 isoform X4

    2. XM_039112609.1 → XP_038968537.1  putative ATP-dependent RNA helicase DHX57 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JZH9
      Related
      ENSRNOP00000071053.3, ENSRNOT00000090688.3
      Conserved Domains (4) summary
      COG1643
      Location:504 → 1301
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      cd14317
      Location:184 → 221
      UBA_DHX57; UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins
      pfam05773
      Location:249 → 422
      RWD; RWD domain
      pfam18345
      Location:308 → 326
      zf_CCCH_4; Zinc finger domain

    3. XM_039112610.1 → XP_038968538.1  putative ATP-dependent RNA helicase DHX57 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JZH9, A0A8I6A546
      Related
      ENSRNOP00000087092.2, ENSRNOT00000107942.2
      Conserved Domains (4) summary
      COG1643
      Location:451 → 1248
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      cd14317
      Location:131 → 168
      UBA_DHX57; UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins
      pfam05773
      Location:196 → 369
      RWD; RWD domain
      pfam18345
      Location:255 → 273
      zf_CCCH_4; Zinc finger domain

    4. XM_039112613.1 → XP_038968541.1  putative ATP-dependent RNA helicase DHX57 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JZH9
      Related
      ENSRNOP00000099483.1, ENSRNOT00000130652.1
      Conserved Domains (4) summary
      COG1643
      Location:398 → 1195
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      cd14317
      Location:78 → 115
      UBA_DHX57; UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins
      pfam05773
      Location:143 → 316
      RWD; RWD domain
      pfam18345
      Location:202 → 220
      zf_CCCH_4; Zinc finger domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools