Prodh proline dehydrogenase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prodhprovided by MGI
Official Full Name: proline dehydrogenaseprovided by MGI
Primary source: MGI:MGI:97770
See related: Ensembl:ENSMUSG00000003526 AllianceGenome:MGI:97770
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pro1; Pro-1; Ym24d07
Summary: Predicted to enable FAD binding activity; amino acid binding activity; and proline dehydrogenase activity. Predicted to be involved in proline catabolic process to glutamate and regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway. Located in mitochondrion. Is expressed in several structures, including adipose tissue; cardiovascular system; central nervous system; forelimb bud; and male reproductive gland or organ. Human ortholog(s) of this gene implicated in amino acid metabolic disorder; hyperprolinemia type 1; and schizophrenia 4. Orthologous to human PRODH (proline dehydrogenase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in liver adult (RPKM 99.9), kidney adult (RPKM 99.6) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 A3; 16 11.19 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (17889593..17907147, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (18071726..18089283, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PRODH1-mediated proline metabolism promotes pancreatic ductal adenocarcinoma growth.
Title: Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions.
Here, we show that Prodh-deficient mice with elevated CNS L-proline display specific deficits in high-frequency GABA-ergic transmission and gamma-band oscillations. We find that L-proline is a GABA-mimetic and can act at multiple GABA-ergic targets
Title: Cytosolic Accumulation of L-Proline Disrupts GABA-Ergic Transmission through GAD Blockade.
PRODH/POX and succinate regulated mitochondrial respiration.
Title: Co-regulation of mitochondrial respiration by proline dehydrogenase/oxidase and succinate.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Spontaneous (1) 1 citation
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Prodh (e-PCR), detects polymorphism
- UniSTS:265736

Prodh (e-PCR), detects polymorphism
- UniSTS:144266

RH124940 (e-PCR)
- UniSTS:161762

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables FAD binding	IBA Inferred from Biological aspect of Ancestor more info
enables FAD binding	ISO Inferred from Sequence Orthology more info
enables FAD binding	ISS Inferred from Sequence or Structural Similarity more info
enables amino acid binding	IEA Inferred from Electronic Annotation more info
enables amino acid binding	ISO Inferred from Sequence Orthology more info
enables proline dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables proline dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables proline dehydrogenase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in proline catabolic process to glutamate	IBA Inferred from Biological aspect of Ancestor more info
involved_in proline catabolic process to glutamate	IEA Inferred from Electronic Annotation more info
involved_in regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	HDA more info	PubMed
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: proline dehydrogenase 1, mitochondrial

Names: proline dehydrogenase, mitochondrial; proline oxidase

NP_035302.2

EC 1.5.5.2

XP_006521926.1

EC 1.5.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.